NR 546 Advanced Pharmacology Psychopharmacology
for the Psychiatric-Mental Health Nurse Practitioner
Midterm Exam Week 4 2025\2026
1. How does the orbitofrontal cortex (OFC) affect the amygdala?CORRECT
ANSWERS inhibits andactivates the amygdala
2. Wernicke's area is associated with which of the following?CORRECT
ANSWERS speech compre-hension
3. The limbic system is associated with which of the followingCORRECT
ANSWERS emotion andlearning
4. Which brain structure is most associated with long term
memory?CORRECT ANSWERS hip-pocampus
5. When prescribing psychotropic medications, the PMHNP knows that these
,medications work within which specific areas?CORRECT ANSWERS mood
6. Which of the following are involved in regulating neurotransmission via ex-
citation-secretion coupling?CORRECT ANSWERS voltage-sensitive sodium channels
and voltage-sen-sitive calcium channels
7. What system influences the length of time for a drug to achiev
efficacy?CORRECT ANSWERS -
signal transduction cascades
8. One of the signal transduction cascades, pass the message from a first
receptor to a second messenger.CORRECT ANSWERS G protein linked systems
9. Human central nervous system communication at synapses is which of the
following?CORRECT ANSWERS chemical
10. Which of the following is an excitatory neurotransmitter?CORRECT
ANSWERS glutamate
, 11. Which statement correctly pairs the pharmacodynamic effect with its defi-
nition?CORRECT ANSWERS antagonist effect - drug binds to receptor, but does not
activate a response
12. A major current hypothesis for the cause of schizophrenia proposes thatN-
methyl-d-aspartate (NMDA) receptors may be which of the following?
Correct!CORRECT ANSWERS hypofunctional
13. Which medication is least associated with weight gain?CORRECT ANSWERS
aripiprazole
14. Which dopamine pathway is associated with positive symptoms of schiz-
ophrenia?CORRECT ANSWERS mesolimbic pathway
15. Which pathway is associated with negative symptoms?CORRECT ANSWERS
The mesocorticalpathway
16. Is part of the extrapyramidal nervous system and associated with ex-
trapyramidal symptoms (EPS)CORRECT ANSWERS nigrostriatal pathway
for the Psychiatric-Mental Health Nurse Practitioner
Midterm Exam Week 4 2025\2026
1. How does the orbitofrontal cortex (OFC) affect the amygdala?CORRECT
ANSWERS inhibits andactivates the amygdala
2. Wernicke's area is associated with which of the following?CORRECT
ANSWERS speech compre-hension
3. The limbic system is associated with which of the followingCORRECT
ANSWERS emotion andlearning
4. Which brain structure is most associated with long term
memory?CORRECT ANSWERS hip-pocampus
5. When prescribing psychotropic medications, the PMHNP knows that these
,medications work within which specific areas?CORRECT ANSWERS mood
6. Which of the following are involved in regulating neurotransmission via ex-
citation-secretion coupling?CORRECT ANSWERS voltage-sensitive sodium channels
and voltage-sen-sitive calcium channels
7. What system influences the length of time for a drug to achiev
efficacy?CORRECT ANSWERS -
signal transduction cascades
8. One of the signal transduction cascades, pass the message from a first
receptor to a second messenger.CORRECT ANSWERS G protein linked systems
9. Human central nervous system communication at synapses is which of the
following?CORRECT ANSWERS chemical
10. Which of the following is an excitatory neurotransmitter?CORRECT
ANSWERS glutamate
, 11. Which statement correctly pairs the pharmacodynamic effect with its defi-
nition?CORRECT ANSWERS antagonist effect - drug binds to receptor, but does not
activate a response
12. A major current hypothesis for the cause of schizophrenia proposes thatN-
methyl-d-aspartate (NMDA) receptors may be which of the following?
Correct!CORRECT ANSWERS hypofunctional
13. Which medication is least associated with weight gain?CORRECT ANSWERS
aripiprazole
14. Which dopamine pathway is associated with positive symptoms of schiz-
ophrenia?CORRECT ANSWERS mesolimbic pathway
15. Which pathway is associated with negative symptoms?CORRECT ANSWERS
The mesocorticalpathway
16. Is part of the extrapyramidal nervous system and associated with ex-
trapyramidal symptoms (EPS)CORRECT ANSWERS nigrostriatal pathway
