MCB 150 UIUC EXAM FINAL VERIFIED
QUESTIONS AND 100% CORRECT
ANSWERS
\Q\.Uses of microtubules - ANSWER-✔Guiding intracellular transport, segregating
chromosomes during mitosis, propulsion or sweeping of fluids over membranes
\Q\.Tubulin - ANSWER-✔globular protein that makes up microtubules
a dimer, composed of two 55 kDa polypeptides (a tubulin and B tubulin)
\Q\.Microtubule structure - ANSWER-✔13 linear "protofilaments" surrounding hollow core
assembled head-to-tail, has polarity
\Q\.Dynamic Instability - ANSWER-✔Alternating cycles of growth and shrinkage
first shown by Mitchison and Kirchner in 1984
\Q\.Colchicine and Colcemid - ANSWER-✔drugs that block microtubule assembly by binding
tubulin
\Q\.Vincristine and vinblastine - ANSWER-✔drugs that selectively inhibit the microtubule
assembly by binding tubulin in rapidly dividing cells
\Q\.Taxol - ANSWER-✔stabilizes microtubules rather than block formation
, \Q\.MOC - ANSWER-✔Microtubule Organizing Centers, Centrosome, located adjacent to the
nucleus in interphase cells
\Q\.Centrosome - ANSWER-✔MT Organizing center, in animal cells consists of a pair of
centrioles surrounded by pericentriolar material
\Q\.Centrioles - ANSWER-✔pair of structures made of microtubules in a "nine triplet"
arrangement with connecting proteins
\Q\.PCM - ANSWER-✔Pericentriolar Material, amorphous (without shape) collection of
proteins from which the MTs emanate
\Q\.Gamma Tubulin - ANSWER-✔Source for new MTs, Platform for new MT dimers
\Q\.Dynein - ANSWER-✔Motor protein that moves towards the minus end
\Q\.Kinesin - ANSWER-✔Motor protein that moves towards the plus end
\Q\.Axoneme - ANSWER-✔Structural unit of cilia and flagella, "9+2" pattern, only has Dyneins
\Q\.Basal Body - ANSWER-✔Minus ends of MTs of cilia and flagella are anchored into this
structure
\Q\.Lamin B - ANSWER-✔Stay bound to the nuclear membrane during prophase
\Q\.Lamin A & C - ANSWER-✔Do not stay bound to the nuclear membrane during prophase
QUESTIONS AND 100% CORRECT
ANSWERS
\Q\.Uses of microtubules - ANSWER-✔Guiding intracellular transport, segregating
chromosomes during mitosis, propulsion or sweeping of fluids over membranes
\Q\.Tubulin - ANSWER-✔globular protein that makes up microtubules
a dimer, composed of two 55 kDa polypeptides (a tubulin and B tubulin)
\Q\.Microtubule structure - ANSWER-✔13 linear "protofilaments" surrounding hollow core
assembled head-to-tail, has polarity
\Q\.Dynamic Instability - ANSWER-✔Alternating cycles of growth and shrinkage
first shown by Mitchison and Kirchner in 1984
\Q\.Colchicine and Colcemid - ANSWER-✔drugs that block microtubule assembly by binding
tubulin
\Q\.Vincristine and vinblastine - ANSWER-✔drugs that selectively inhibit the microtubule
assembly by binding tubulin in rapidly dividing cells
\Q\.Taxol - ANSWER-✔stabilizes microtubules rather than block formation
, \Q\.MOC - ANSWER-✔Microtubule Organizing Centers, Centrosome, located adjacent to the
nucleus in interphase cells
\Q\.Centrosome - ANSWER-✔MT Organizing center, in animal cells consists of a pair of
centrioles surrounded by pericentriolar material
\Q\.Centrioles - ANSWER-✔pair of structures made of microtubules in a "nine triplet"
arrangement with connecting proteins
\Q\.PCM - ANSWER-✔Pericentriolar Material, amorphous (without shape) collection of
proteins from which the MTs emanate
\Q\.Gamma Tubulin - ANSWER-✔Source for new MTs, Platform for new MT dimers
\Q\.Dynein - ANSWER-✔Motor protein that moves towards the minus end
\Q\.Kinesin - ANSWER-✔Motor protein that moves towards the plus end
\Q\.Axoneme - ANSWER-✔Structural unit of cilia and flagella, "9+2" pattern, only has Dyneins
\Q\.Basal Body - ANSWER-✔Minus ends of MTs of cilia and flagella are anchored into this
structure
\Q\.Lamin B - ANSWER-✔Stay bound to the nuclear membrane during prophase
\Q\.Lamin A & C - ANSWER-✔Do not stay bound to the nuclear membrane during prophase
