IMMUNOLOGY QUIZ QUESTIONS WITH CORRECT ANSWERS #21
All of the following molecules act as transcription factors in T cell activation signaling
EXCEPT: - correct answer Ras
The strength of integrin-dependent binding of T cells to antigen-presenting cells (apcs)
may be rapidly increased by which one of the following mechanisms? - correct answer
Integrin clustering and increased integrin affinity are induced by chemokines and
antigen recognition.
A drug that interferes with the function of sphingosine 1-phosphate (S1P) is approved
for treating an autoimmune disease mediated by T cells. Which of the following is a way
in which S1P promotes T cell responses? - correct answer S1P acts as a
chemoattractant and binds to receptors expressed on T cells in lymph nodes, which
promotes their egress out of the nodes via efferent lymphatics.
Which of the following comparisons between Th1 and Th2 cells is true? - correct answer
Th1 cells produce interferon (IFN)-gamma but not IL-4, and Th2 cells produce IL-4 but
not IFN-gamma.
Which one of the following statements accurately describes antigen recognition events
in a lymph node during a helper T cellâ dependent antibody response to a protein
antigen? - correct answer Naive B cells recognize intact proteins, generate peptide
fragments of these proteins, and present them in complexes with MHC molecules to
differentiated helper T cells.
Which of the following mechanisms contributes to the change from B cell production of
membrane Ig to secreted Ig? - correct answer Alternative processing of primary RNA
transcripts to remove the transmembrane domain and include a secretory tail piece.
Which of the following events occur only within germinal centers? - correct answer Ig
affinity maturation
Which one of the following B cell responses is stimulated by CD40L on follicular helper
T (Tfh) cells? - correct answer Increased expression of activation-induced cytidine
deaminase (AID)
Which one of the following cell types would be most potent at activating naive T cells? -
correct answer Dendritic cells
A 2-year-old boy suffers from recurrent bacterial infection of his ears, sinuses, lungs,
and skin; laboratory studies indicate absence of sialylated Lewis X on his leukocytes.
He is diagnosed with leukocyte adhesion deficiency type 2 (LAD-2). Which type of
adhesive interaction required for leukocyte migration is defective in this boy? - correct
answer E-selectin ligand binding to E-selectin
, All of the following protein-protein interactions are involved in activation of naive helper
T cells by antigen-presenting cells (apcs) EXCEPT: - correct answer Binding of CD40L
on the T cell with CD40 on the APC
Which one of the following statements about the molecules B7-1 and B7-2 is NOT true?
- correct answer B7-1 activates T cells, and B7-2 inhibits immune responses.
Which of the following molecules is NOT important in the interaction between a
cytotoxic T lymphocyte and a target cell? - correct answer B7-1
The induction phase of a cell-mediated immune response includes which of the
following events? - correct answer Clonal expansion of CD8+ T cells within a lymph
node
Which one of the following statements about humoral immune responses is true? -
correct answer Naive B cells are required for initiation of primary responses and
memory B cells are required for initiation of secondary responses.
Which of the following statements is true about Tfh migration during a T-dependent B
cell response in a lymph node? - correct answer Tfh migrate from inside follicles, where
they are formed, to the T cell zone outside follicles, in response to CCR7 biding
chemokines.
Which one of the following is a B cell molecule that is important for the production of ige
antibodies? - correct answer CD40
The initial cellular events that are induced by antigen-mediated cross-linking of the BCR
complex include all of the following EXCEPT: - correct answer Increased expression of
CCR7, promoting migration into lymph node follicles
The B cell receptor (BCR) complex and the signaling cascades to which it is linked
share many similarities with the T cell receptor (TCR) complex and its linked signaling
cascades. Which of the following comparisons between BCR and TCR signaling is NOT
true? - correct answer The tyrosine kinase Lck bound to CD4/CD8 coreceptors
phosphorylates itams in responses to TCR and BCR antigen recognition.
Which of the following statements about C3 is NOT correct? - correct answer Activated
C3 is a serine protease that cleaves C4.
Which of the following statements about Ig Fc receptors is NOT true? - correct answer
There are Fc receptors specific for all common Ig isotypes.
An 8-month-old boy with a 3-month history of recurrent upper and lower respiratory tract
infections is admitted to the hospital. The physicians consider the possibility of a
hereditary immune disorder and run several tests, eventually determining that the
patient has undetectable levels of serum iga. The infant is treated with strong antibiotics
All of the following molecules act as transcription factors in T cell activation signaling
EXCEPT: - correct answer Ras
The strength of integrin-dependent binding of T cells to antigen-presenting cells (apcs)
may be rapidly increased by which one of the following mechanisms? - correct answer
Integrin clustering and increased integrin affinity are induced by chemokines and
antigen recognition.
A drug that interferes with the function of sphingosine 1-phosphate (S1P) is approved
for treating an autoimmune disease mediated by T cells. Which of the following is a way
in which S1P promotes T cell responses? - correct answer S1P acts as a
chemoattractant and binds to receptors expressed on T cells in lymph nodes, which
promotes their egress out of the nodes via efferent lymphatics.
Which of the following comparisons between Th1 and Th2 cells is true? - correct answer
Th1 cells produce interferon (IFN)-gamma but not IL-4, and Th2 cells produce IL-4 but
not IFN-gamma.
Which one of the following statements accurately describes antigen recognition events
in a lymph node during a helper T cellâ dependent antibody response to a protein
antigen? - correct answer Naive B cells recognize intact proteins, generate peptide
fragments of these proteins, and present them in complexes with MHC molecules to
differentiated helper T cells.
Which of the following mechanisms contributes to the change from B cell production of
membrane Ig to secreted Ig? - correct answer Alternative processing of primary RNA
transcripts to remove the transmembrane domain and include a secretory tail piece.
Which of the following events occur only within germinal centers? - correct answer Ig
affinity maturation
Which one of the following B cell responses is stimulated by CD40L on follicular helper
T (Tfh) cells? - correct answer Increased expression of activation-induced cytidine
deaminase (AID)
Which one of the following cell types would be most potent at activating naive T cells? -
correct answer Dendritic cells
A 2-year-old boy suffers from recurrent bacterial infection of his ears, sinuses, lungs,
and skin; laboratory studies indicate absence of sialylated Lewis X on his leukocytes.
He is diagnosed with leukocyte adhesion deficiency type 2 (LAD-2). Which type of
adhesive interaction required for leukocyte migration is defective in this boy? - correct
answer E-selectin ligand binding to E-selectin
, All of the following protein-protein interactions are involved in activation of naive helper
T cells by antigen-presenting cells (apcs) EXCEPT: - correct answer Binding of CD40L
on the T cell with CD40 on the APC
Which one of the following statements about the molecules B7-1 and B7-2 is NOT true?
- correct answer B7-1 activates T cells, and B7-2 inhibits immune responses.
Which of the following molecules is NOT important in the interaction between a
cytotoxic T lymphocyte and a target cell? - correct answer B7-1
The induction phase of a cell-mediated immune response includes which of the
following events? - correct answer Clonal expansion of CD8+ T cells within a lymph
node
Which one of the following statements about humoral immune responses is true? -
correct answer Naive B cells are required for initiation of primary responses and
memory B cells are required for initiation of secondary responses.
Which of the following statements is true about Tfh migration during a T-dependent B
cell response in a lymph node? - correct answer Tfh migrate from inside follicles, where
they are formed, to the T cell zone outside follicles, in response to CCR7 biding
chemokines.
Which one of the following is a B cell molecule that is important for the production of ige
antibodies? - correct answer CD40
The initial cellular events that are induced by antigen-mediated cross-linking of the BCR
complex include all of the following EXCEPT: - correct answer Increased expression of
CCR7, promoting migration into lymph node follicles
The B cell receptor (BCR) complex and the signaling cascades to which it is linked
share many similarities with the T cell receptor (TCR) complex and its linked signaling
cascades. Which of the following comparisons between BCR and TCR signaling is NOT
true? - correct answer The tyrosine kinase Lck bound to CD4/CD8 coreceptors
phosphorylates itams in responses to TCR and BCR antigen recognition.
Which of the following statements about C3 is NOT correct? - correct answer Activated
C3 is a serine protease that cleaves C4.
Which of the following statements about Ig Fc receptors is NOT true? - correct answer
There are Fc receptors specific for all common Ig isotypes.
An 8-month-old boy with a 3-month history of recurrent upper and lower respiratory tract
infections is admitted to the hospital. The physicians consider the possibility of a
hereditary immune disorder and run several tests, eventually determining that the
patient has undetectable levels of serum iga. The infant is treated with strong antibiotics
