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NSC 408 Final Exam – 100 Questions on Metabolism, Starvation & Cancer Nutrition

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This comprehensive study resource for NSC 408 (Nutritional Sciences) contains 100 final exam questions and correct answers, updated for the Fall 2025/2026 academic year at Arizona State University. The document deeply explores advanced topics in human metabolism, nutritional biochemistry, and metabolic adaptations to physiological stress, offering a robust prep tool for upper-division nutrition, dietetics, or pre-health students. Major concepts covered include: Alanine-Glucose Cycle, Krebs Cycle, Glycolysis, and β-oxidation Metabolic responses to adapted starvation, sepsis/infection, and trauma Regulation of energy balance via insulin, glucagon, catecholamines, and cortisol Transamination, urea cycle, amino acid metabolism, and ketogenesis Nutrigenomics, epigenetics, and cancer-linked dietary pathways including BRCA, VDR, MTHFR gene variants The Warburg Effect, tumor metabolism, and the role of folate, fiber, and bile acids in cancer progression With a mix of conceptual questions, biochemical pathways, diagram labeling prompts, and clinical application scenarios, this document is ideal for review, self-testing, and reinforcing course mastery. All answers are clearly marked and based on scientifically accurate explanations. Recommended for: Students enrolled in NSC 408 at Arizona State University Upper-level undergraduates in Nutrition, Dietetics, Biochemistry, or Pre-Med programs Learners preparing for exams in metabolic regulation, clinical nutrition, or molecular biology of nutrition Individuals seeking advanced understanding of human energy metabolism and its clinical implications This document supports deep understanding of nutrient metabolism, stress physiology, gene-nutrient interactions, and biochemical assessment of health, all crucial for careers in nutrition, health sciences, or medicine. Keywords: NSC 408, final exam nutrition, alanine cycle, ketogenesis, adapted starvation, glycolysis, krebs cycle, urea cycle, insulin regulation, glucagon, cortisol, epigenetics, BRCA gene, MTHFR, cancer nutrition, Warburg effect, fatty acid metabolism, beta oxidation, nutrient metabolism, Arizona State University

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NSC 408 Final exam Questions and
Answers | Fall 2025/26 Update | 100%
Correct


Describe the Alanine-Glucose Cycle - 🧠 ANSWER ✔✔1. In the muscle,

glycogen (polymer of glucose) is converted to glucose which undergoes

glycolysis (to release ATP energy) making pyruvate

2. Pyruvate (alpha-ketoacid) is trans-animated with glutamate (amino acid,

which comes from the trans-animation of alpha-ketoglutarate and leucine)

to make Alanine (amino acid) and alpha-ketoglutarate (alpha-ketoacid).

3. Alanine travels through blood to the liver, where it is trans-animated with

alpa-ketoglutarate to make glutamate and pyruvate.

4. Glutamate is deanimated to form NH3 which enters urea cycle and forms

urea for excretion

,5. Pyruvate undergoes gluconeogenesis forming glucose which then is

released into the blood and goes back to the muscle for energy usage


Glycolysis Definition/purpose - 🧠 ANSWER ✔✔- First step of cellular

respiration (purpose is to make energy [ATP] for cell to use)

- Breaks down one molecule of glucose into two molecules of pyruvate

- Occurs in cytoplasm of cell

Glucagon

Insulin

Cytokines

Catecholamines


Cortisol - 🧠 ANSWER ✔✔G - Raises blood glucose (activates glycogen

breakdown & gluconeogenesis)

- released in response to low blood glucose levels (adapted startvation)




I - Lowers blood glucose, causes cells to uptake glucose from blood to use

for energy)

, Cyto- Proteins involved in the inflammatory response (messengers)




Cat- Include adrenaline and dopamine (fight or flight response)




Cort - Increase blood sugar through gluconeogenesis

- Released in response to stress and low blood glucose

Describe what happens for during adapted starvation for energy production

- 🧠 ANSWER ✔✔Increased Responses


1. Adipose tissue is broken down into fatty acids and glycerol. Fatty acids

are transported to the liver for ketogenesis which produces ketones that

enter the blood and travel to muscles for energy use. Fatty acids are also

taken to the muscle. Glycerol is taken to the liver for gluconeogenesis.




Regular Responses

1. Glycogenolysis and gluconeogenesis produce glucose which travels to

the muscles and is broken down into pyruvate then turned into alanine and




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