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NSC 408 Final Exam – 100 Questions on Metabolic Disorders, Cancer Nutrition & Epigenetics

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This document contains 100 exam-style questions and correct answers for the NSC 408: Nutritional Sciences final at Arizona State University, updated for the 2025/2026 academic year. It covers advanced human nutrition topics with clinical and biochemical depth, structured to support students preparing for upper-level final exams or health science assessments. Key topics include: Metabolic pathways such as glycolysis, β-oxidation, Krebs cycle, ketogenesis, gluconeogenesis, and the alanine-glucose cycle Adapted starvation, sepsis, and metabolic shifts during trauma or diabetes Cancer metabolism, including the Warburg effect, tumor glucose utilization, oncogene regulation, and colon cancer pathogenesis Epigenetics and nutrigenomics, such as DNA methylation, histone modification, and the roles of folate, choline, B12, and alcohol in gene regulation Hormonal regulation involving insulin, glucagon, leptin, cortisol, and growth hormone Role of gut microbiota, metabolic syndrome, and inflammation in chronic diseases Bone health, osteoporosis mechanisms, vitamin D activation, and hormone influences on calcium homeostasis This document integrates applied biochemistry, nutrition science, and molecular biology into real-world scenarios, enabling deep understanding and exam success. Questions are phrased in multiple-choice, matching, and fill-in-the-blank formats, and each correct answer is clearly provided. Recommended for: Students enrolled in NSC 408 at ASU Undergraduates in nutrition, dietetics, pre-med, biochemistry, or health sciences Students preparing for clinical nutrition exams, graduate study in nutrigenomics, or research in metabolism and disease Learners looking to reinforce pathway-based metabolic understanding for future clinical application This resource is ideal for last-minute exam prep, cumulative reviews, or structured self-study. Keywords: NSC 408, final exam, nutrition science, glucose metabolism, cancer nutrition, epigenetics, ketogenesis, warburg effect, insulin signaling, vitamin D, folate, methylation, metabolic syndrome, gut microbiota, colon cancer, gluconeogenesis, cortisol, osteoblasts, personalized nutrition,

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NSC 408 Final Exam Questions and
Answers | Fall 2025/26 Update | 100%
Correct

The relationship between vitamin D intake and risk for prostate cancer tells

us what? - 🧠 ANSWER ✔✔There is some optimal level of vitamin D intake

for protecting against prostate cancer, not too little, not too much.

Which of the following is a factor that helps determine the effect of a given

nutrient in our bodies? - 🧠 ANSWER ✔✔-dosage (how much is consumed)-

nutrient timing (when the nutrient is consumed)-genotype

(mutations/polymorphisms)- co-exposure (other environmental factors that

can interact with the nutrient)

Which of the following are post-translational modifications of proteins? - 🧠

ANSWER ✔✔-Phosphorylation

,-Acetylation

-Methylation

After a gene is transcribed into messenger RNA,

_____

are generally spliced out, and excluded from the final mRNA transcript,

while most or all of the

______

which are known as the coding regions, remain, and are combined to

create the final mRNA transcript from which the protein is translated. - 🧠

ANSWER ✔✔-introns


-exons

How do humans possess millions of functional proteins in our bodies,

despite having a vastly smaller number of genes which encode for these

proteins? - 🧠 ANSWER ✔✔- Post-translational modifications of proteins

(phosphorylation, methylation, etc.) give proteins different structures and

functions

,- Differential/alternative splicing produces multiple different proteins per

gene

What information can be ascertained by using proteomic techniques? - 🧠

ANSWER ✔✔- The presence of multiple proteins


- Quantities of multiple proteins

- Information about post-translational modifications

- Changes in protein networks

List two ways a change in DNA can lead to a change in nutrient

metabolism. - 🧠 ANSWER ✔✔ubiquitination and phosphorylation


Nitrogen waste from amino acid degradation is excreted in the urine in the

form of? - 🧠 ANSWER ✔✔Urea


In which organ does the urea cycle occur? - 🧠 ANSWER ✔✔liver


Under normal circumstances, pyruvate is converted to either acetyl-CoA or

oxaloacetate. When pyruvate builds up faster than it is being used in the

Krebs cycle, what immediate alternative pathway does it take? - 🧠

ANSWER ✔✔It is converted to lactate


ketogenic amino acids - 🧠 ANSWER ✔✔leucine and lysine

COPYRIGHT©PROFFKERRYMARTIN 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE.
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, glucogenic amino acids - 🧠 ANSWER ✔✔all except leucine and lysine; can

be converted into intermediates that feed into gluconeogenesis

both ketogenic and glucogenic amino acids - 🧠 ANSWER

✔✔phenylalanine, isoleucine, threonine, tryptophan and tyrosine


What is the major provider of carbons for gluconeogenesis in the absence

of glucose? - 🧠 ANSWER ✔✔amino acids


Under normal circumstances, pyruvate is converted to either acetyl-CoA or

oxaloacetate. Under what conditions would you expect pyruvate to build up

faster than it is being used? - 🧠 ANSWER ✔✔- During anaerobic exercise


- When oxygen levels are insufficient for oxidative reactions

Excess amino acids are stored as proteins so that they can be used for

energy in times of fasting. - 🧠 ANSWER ✔✔false


Alanine transaminase

_____

(adds/removes) an amine group from/to alanine to create


_____ - 🧠 ANSWER ✔✔- removes


- urea

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