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NSC 408 Final Exam Review – 100 Questions on Epigenetics, Starvation Metabolism & Cancer Pathways

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This detailed final exam review for NSC 408: Nutritional Sciences at Arizona State University includes 100 fully answered questions, thoroughly updated for the Fall 2025/2026 academic year. It serves as a comprehensive and accurate resource for students aiming to master advanced concepts in human metabolism, clinical nutrition, and molecular nutrition science. The document covers high-level topics critical for upper-division undergraduates and pre-health students, including: Epigenetics and gene expression: histone modification, DNA methylation, CpG islands, nutrigenomics, and maternal diet effects (e.g., Agouti mouse model) Metabolic regulation: gluconeogenesis, glycolysis, β-oxidation, ketogenesis, urea cycle, and amino acid catabolism Stress and starvation physiology: metabolic differences in trauma, sepsis, and adapted starvation Cancer metabolism: Warburg effect, tumor glucose uptake, pyruvate dehydrogenase complex (PDC) regulation, and use of glycolytic imaging in diagnostics Hormonal control: insulin, glucagon, cortisol, IGF-1, and their metabolic effects Nutrient transport and lipid metabolism: bile acid function, omega-3/omega-6 fatty acids, chylomicron formation Molecular pathways: PDK regulation, transcriptional control, alternative splicing, post-translational modification With content drawn from lectures, current literature, and textbook-aligned sources, this guide is ideal for high-stakes exam prep, including concept review, recall practice, and applied clinical nutrition analysis. Best suited for: Students in NSC 408 at ASU Upper-level undergraduates studying nutrition, dietetics, biochemistry, or pre-med Individuals preparing for exams involving metabolism, cancer nutrition, and molecular biology Learners interested in gene-diet interactions, metabolic adaptation, and chronic disease nutrition This document enhances understanding of nutrition at the molecular level, supporting success in advanced coursework and clinical application. Keywords: NSC 408, Arizona State University, final exam review, metabolic pathways, gluconeogenesis, ketogenesis, epigenetics, DNA methylation, Warburg effect, cancer metabolism, nutrient-gene interaction, insulin signaling, amino acid metabolism, glycolysis, starvation metabolism, bile acids, folate metabolism, PDC regulation, histone modification, fatty acid synthesis

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NSC 408 Final Exam Review Questions
and Answers | Fall 2025/26 Update |
100% Correct

Which of the following is a factor that helps determine the effect of a given

nutrient in our bodies?




Dosage (how much is consumed)

Nutrient timing (when the nutrient is consumed)

Genotype (mutations/polymorphisms)

Co-exposure (other environmental factors that can interact with the

nutrient) - 🧠 ANSWER ✔✔All of the above

,What does the Agouti mouse experiment demonstrate? - 🧠 ANSWER

✔✔Maternal diet during gestation has a profound effect on the phenotype

of the offspring

Based on your knowledge of the folate-methionine pathway, which of the

following would likely affect breast cancer risk due to altered DNA

methylation patterns?




Increased dietary exposure to intermediates of this pathway (folate,

methionine, zinc, etc.)

A polymorphism in MTHFR, the rate-limiting enzyme in this pathway


Increased FOL-1 (folate receptor) expression - 🧠 ANSWER ✔✔All of the

above

What is most likely the largest provider of carbons for gluconeogenesis in

the absence of glucose? - 🧠 ANSWER ✔✔Amino acids


By which process is an amino group removed from an amino acid and

placed onto an alpha-keto acid, creating a new amino acid and a new

alpha-keto acid? - 🧠 ANSWER ✔✔Transamination

, Based on your knowledge of the metabolic pathways of glucose, amino

acids, and fats, which would most likely be elevated in a patient with a non-

functioning pyruvate carboxylase (PC) enzyme? - 🧠 ANSWER ✔✔Blood

alanine, blood lactate, ketone bodies

Our bodies produce a vastly greater amount of proteins than the number of

genes we have, even though our genes encode for these proteins. Which

of the following is *NOT* a method by which this occurs?




Posttranslational modification of proteins changes protein shape and

function.

Alternate splicing (splice variants) of RNA during transcription yields distinct

proteins.

Backward transcription of genes yields proteins with opposite effects.

Alternate transcription start sites results in different proteins from the same

gene. - 🧠 ANSWER ✔✔Backward transcription of genes yields proteins with

opposite effects.

Why didn't the completion of the human genome project give us the

answers to curing all diseases? - 🧠 ANSWER ✔✔The vast majority of


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