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Terms in this set (1372)
"I TALC"
Interferons
Tyrosine Kinase Inhibitors
Key drugs that can cause Amiodarone
hypothyroidism Lithium
Carbamazepin
e
Conditions: Hashimoto's disease
Levothyroxine IV:PO 0.75:1 (IV:PO)
1.6 mcg/kg/day (IBW)
Full replacement dose
levothyroxine If known CAD: start with 12.5-25 mcg daily
Orangutans Will Vomit On You Right Before They Become Large Proud
Giants
25 Orange
50 White (no
dye) 75
Violet
Levothyroxine tablet colors 88 Olive
100 Yellow
112 Rose
125 Brown
137 Turquoise
150 Blue
175 Lilac
200 Pink
300 Green
, Iodine
Amiodarone
Drug induced causes of
hyperthyroidism Interferons
Radiographic contrast media
Antithyroid (PTU preferred- give 1 hour
before iodide) Inorganic iodide therapy
treatment for thyroid storm (SSKI or Lugol's)
Beta Blocker
(Propranolol) Systemic
steroid (dexamethasone)
Aggressive cooling (APAP, cooling blankets, supportive treatments)
Hyperthyroidism during pregnancy should be treated with
propylthiouracil (PTU) during the first trimester then
Hyperthyroid in pregnancy methimazole during the second and third trimesters. Although
methimazole is a teratogen, the teratogenic effects are less
during the second and third trimesters, and PTU can cause
liver failure, which is why it is substituted out.
Adrenal gland produces too much cortisol or exogenous steroids
Cushing's syndrome
are taken in doses higher than normal amounts of endogenous
cortisol
a condition that occurs when the adrenal glands do not produce
Addison's disease
enough cortisol; Addisonian crisis (volume depletion and
hypotension, which can be fatal)
(Cute Hot Pharmacists and Physicians Marry Together & Deliver Babies)
o Cortisone (25 mg): short acting
o Hydrocortisone (20 mg): short acting
o Prednisone (5 mg): intermediate acting
o Prednisolone (5 mg): intermediate acting
Steroids: least to most potent
o Methylprednisolone (4 mg): intermediate acting
o Triamcinolone (4 mg): intermediate acting
o Dexamethasone (0.75 mg): long acting, highest potency
o Betamethasone (0.6 mg): long acting, highest potency
A patient is immunosuppressed when using >/= 2mg/kg/day or >/=
20mg/day of prednisone or prednisone equivalent for >2
weeks
Immunosuppression from steroids
Immunosuppressed patients cannot receive live vaccines and have a
high risk of infection
, steroid will need to be slowly tapered off: reduce 10-20% every
few days (tapers can last 7-14 days, longer or shorter)
MTX (Trexall): first line in
Traditional DMARDs (disease RA Hydroxychloroquine
modifying anti-rheumatic (Plaquenil) Sulfasalazine
drugs) Leflunomide (Arava)
MTX (Trexall): first line in RA
- irreversibly binds and inhibit dihydrofolate reductase, inhibiting folate
- 7.5 to 20 mg once weekly
Traditional DMARDs (disease
- hepatotoxicity (avoid alcohol), myelosuppression, mucosistis/stomatitis,
modifying anti-rheumatic teratogenic
drugs): MTX - monitor: CBC, LFTs, chest X-ray, hep B/C
- folate replacement
- renal elimination is decreased by aspirin/NSAIDs
Hydroxychloroquine (Plaquenil)
Traditional DMARDs (disease - Irreversible retinopathy
modifying anti-rheumatic - take with food or milk
drugs): hydroxychloroquine - alternative to MTX in liver disease