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Terms in this set (212)
MIC lowest drug concentration that prevents visibile microbial growth in 24
hours
gram (+) bacteria species staph, strep, EC, clostridium, listeria
which antibiotics exhibit time- penicillins, cephalosporins
dependent killing?
how can you increase the killing of dose more frequently, extend the infusion time
a time- dependent antibiotic?
example of concentration- aminoglycosides (gentamicin, tobramycin, amikacin)
dependent antibiotic?
macrolides
aminoglycosides
what are the bacteriostatic tetracyclines
antibiotics (protein synthesis clindamycin
inhibitors)? linezolid
quinupristin, dalfopristin
what is the MOA of penicillins, cell wall inhibitors - bactericidal
cephalosporins, carbapenems, and
vancomycin?
what general ADRs are the nephrotoxicity and neurotoxicity
black box warning for
aminoglycosides?
tobramy
what are the aminoglycosides? cin
gentamic
in
amikaci
n
what type of nephrotoxicity do ATN - acute tubular necrosis
aminoglycosides cause?
, what weight do you use to dose IBW (unless TBW is less)
aminoglycosides? *use ABW if obese ( > 30% IBW)
what organisms are gram (-): GNR, PA
aminoglycosides mainly active
against?
gent/tobra: 4-7 mg/kg
extended interval dosing of the
amikacin: 15-20 mg/kg
aminoglycosides?
*draw random level within 6-16 hours after dose
adjust body weight (ABW) IBW + [0.4(TBW - IBW)]
formula?
desired trough (traditional dosing) trough: < 2
for gent/tobra? peak? mcg/mL peak:
5-10 mcg/mL
amoxicilin brand name Amoxil
what organisms do the penicillins mainly gram (+), some gram (-)
cover?
which penicillin is the DOC in amoxicillin
acute otitis media?
which penicillin has activity against piperacillin
PA?
nafcillin
which penicillins do not
oxacillin
require renal dosing?
dicloxaci
llin
Does Amoxil suspension need to no - stable for 14 days at room temperature
be refrigerated?
how do you need to take Pen VK? on an empty stomach
what IV fluid is ampicillin only NS
compatible with?
what are the main penicillin probenacid, allopurinol - increased
drug interactions? penicillin levels may decrease levels of
oral contraceptives
what type of killing do time-dependent
cephalosporins exhibit?
what are the first cefazolin and cephalexin
generation
cephalosporins?