NAPLEX Diabetes 2025-2026 Examination Questions with
their Verified A+ Answers Latest Update!
Pre diabetes dx criteria fasting glucose 100-125; 2 hr plasma glucose (75g) 140-199; or A1c 5.7-6.4%
Diabetes criteria for diagnosis symptoms plus random glucose > 200; fasting > 126; 2 hour OGTT > 200 or
A1c > 6.5%
atypical antipsych, azoles (posa), beta agonists, BB (carvedilol,
meds that can increase blood propranolol), cough syrup, cyclosporine, FK, sirolimus,
glucose
Diazoxide, interferon alfa, niacin, octreotide, protease inhib,
quinolones, steroids, thiazides, loops
linezolid, lorcaserin (Belviq), Octreotide (with Type 1),
drugs that lower blood glucose
pentamidine, propranolol and non-selective BB, Quinine,
quinolones
Gestational diabetes goals preprandial < 95; 1 hour post < 140, 2 hours post < 120
Pregestational diabetes goals A1c < 6%, preprandial 60-99, peak post-prandial 100-129
goal waist circumference < 35 inches female; < 40 inches male
goal fiber intake 14 grams per 1,000 kcal; 25 g for females and 38 g for males
who should get aspirin therapy as males > 50 and females > 60 with at least 1 additional factor
primary prevention (HTN, CVD, family hx, smoking, etc)
what should be used if patient has clopidogrel 75mg
aspirin allergy
benefit of ACEI and ARBs delay progression to diabetic nephropathy in those with albuminuria
when do patients qualify for high <40 years with overt CVD or >40 year with CVD risk factors or overt CVD
intensity statin
vaccinations indicated for diabetic Hep B if unvaccinated between 19-59; influenza, pneumococcal; Tetanus if
patients due
ADA guidelines < 7%, preprandial 80-130; peak post-prandial < 180
AACE guidelines < 6.5%, preprandial < 110, peak post-prandial < 140
when should initial therapy A1c >/= 9
contain two drugs
when should initial therapy include A1c > 10 or BG > 300
insulin
at one point should an additional A1c not at goal after 3 months
agent be added
, which three drug metformin + DPP4 + GLP1 or metformin + SGLT2 + GLP1
regimens are not
recommended
medications with only moderate DPP4 inhib, SGLT2 inhib, pramlintide
efficacy
moderate risk of hypoglycemia SU adn meglitinides
drugs that can cause weight loss GLP1 agonists, SGLT2 inhib, primlintide
drugs that cause weight gain insulin, SUs, meglitinides, TZDs
which medications SUs and Meglitinides
increase insulin secretion
decreases hepatic glucose production, decreases glucose
how does metformin work
absorption, and increases sensitivity
when is metformin CI Scr > 1.5 in males, > 1.4 in females
Metaglip metformin and glipizide
Glucovance metformin and glyburide
Actoplus Met pioglitazone and metformin
Avandamet rosiglitazone and metformin
Janumet sitagliptin and metformin
Kombiglyze saxagliptin and metformin
Jentadueto linagliptin and metformin
PrandiMet repaglinide and metformin
Kazano alogliptin and metformin
Invokamet canagliflozin and metformin
Xigduo XR dapagliflozin and metformin
Synjardy empagliflozin and metformin
combo of metformin and what drug topiramate
can increase metabolic acidosis
metformin formulations that Glumetza, Fortamet, Glucophage XR
may cause shell in stool
first gen SUs chlorpropamide (Diabinese), tolazamide, tolbutamide
Glipizide dose (Glucotrol) 5-10 mg daily or BID; max 40mg or 20mg of XL
Glimepiride Amaryl; 1-2mg daily up to 8mg
Duetact glimepiride + pioglitazone
Avandaryl glimepiride + rosiglitazone
Glynase micronized glyburide; 1.5-3mg daily up to 12mg ** better absorption
DiaBeta Glyburide; 2.5-5mg daily up to 20mg
why is glyburide not a preferred weakly active metabolite that is cleared renally
agent?
their Verified A+ Answers Latest Update!
Pre diabetes dx criteria fasting glucose 100-125; 2 hr plasma glucose (75g) 140-199; or A1c 5.7-6.4%
Diabetes criteria for diagnosis symptoms plus random glucose > 200; fasting > 126; 2 hour OGTT > 200 or
A1c > 6.5%
atypical antipsych, azoles (posa), beta agonists, BB (carvedilol,
meds that can increase blood propranolol), cough syrup, cyclosporine, FK, sirolimus,
glucose
Diazoxide, interferon alfa, niacin, octreotide, protease inhib,
quinolones, steroids, thiazides, loops
linezolid, lorcaserin (Belviq), Octreotide (with Type 1),
drugs that lower blood glucose
pentamidine, propranolol and non-selective BB, Quinine,
quinolones
Gestational diabetes goals preprandial < 95; 1 hour post < 140, 2 hours post < 120
Pregestational diabetes goals A1c < 6%, preprandial 60-99, peak post-prandial 100-129
goal waist circumference < 35 inches female; < 40 inches male
goal fiber intake 14 grams per 1,000 kcal; 25 g for females and 38 g for males
who should get aspirin therapy as males > 50 and females > 60 with at least 1 additional factor
primary prevention (HTN, CVD, family hx, smoking, etc)
what should be used if patient has clopidogrel 75mg
aspirin allergy
benefit of ACEI and ARBs delay progression to diabetic nephropathy in those with albuminuria
when do patients qualify for high <40 years with overt CVD or >40 year with CVD risk factors or overt CVD
intensity statin
vaccinations indicated for diabetic Hep B if unvaccinated between 19-59; influenza, pneumococcal; Tetanus if
patients due
ADA guidelines < 7%, preprandial 80-130; peak post-prandial < 180
AACE guidelines < 6.5%, preprandial < 110, peak post-prandial < 140
when should initial therapy A1c >/= 9
contain two drugs
when should initial therapy include A1c > 10 or BG > 300
insulin
at one point should an additional A1c not at goal after 3 months
agent be added
, which three drug metformin + DPP4 + GLP1 or metformin + SGLT2 + GLP1
regimens are not
recommended
medications with only moderate DPP4 inhib, SGLT2 inhib, pramlintide
efficacy
moderate risk of hypoglycemia SU adn meglitinides
drugs that can cause weight loss GLP1 agonists, SGLT2 inhib, primlintide
drugs that cause weight gain insulin, SUs, meglitinides, TZDs
which medications SUs and Meglitinides
increase insulin secretion
decreases hepatic glucose production, decreases glucose
how does metformin work
absorption, and increases sensitivity
when is metformin CI Scr > 1.5 in males, > 1.4 in females
Metaglip metformin and glipizide
Glucovance metformin and glyburide
Actoplus Met pioglitazone and metformin
Avandamet rosiglitazone and metformin
Janumet sitagliptin and metformin
Kombiglyze saxagliptin and metformin
Jentadueto linagliptin and metformin
PrandiMet repaglinide and metformin
Kazano alogliptin and metformin
Invokamet canagliflozin and metformin
Xigduo XR dapagliflozin and metformin
Synjardy empagliflozin and metformin
combo of metformin and what drug topiramate
can increase metabolic acidosis
metformin formulations that Glumetza, Fortamet, Glucophage XR
may cause shell in stool
first gen SUs chlorpropamide (Diabinese), tolazamide, tolbutamide
Glipizide dose (Glucotrol) 5-10 mg daily or BID; max 40mg or 20mg of XL
Glimepiride Amaryl; 1-2mg daily up to 8mg
Duetact glimepiride + pioglitazone
Avandaryl glimepiride + rosiglitazone
Glynase micronized glyburide; 1.5-3mg daily up to 12mg ** better absorption
DiaBeta Glyburide; 2.5-5mg daily up to 20mg
why is glyburide not a preferred weakly active metabolite that is cleared renally
agent?
