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Chamberlain College of Nursing
Antidepressant and Mood Stabilizer Medication Table
Week 5
Course: NR546/NR 546 Advanced
Pharmacology: Psychopharmacology
, THIS ASSIGNMENT SHOULD BE SUBMITTED TO THE WEEK 5 MEDICATION TABLE
Name Indication, starting Half-life (T1/2) Notes/Notable side effects/Precautions
dose, target CYP450 enzyme
symptoms, and
affected
neurotransmitters
SSRIs
Citalopram This selection The parent drug Notable side effects include sexual dysfunction, appetite
(Celexa) describes the has a half-life of changes, nausea, vomiting, diarrhea, constipation, dry mouth,
mechanism of 23-45 hours, insomnia, agitation, tremors, headache, dizziness, sweating,
action and weakly inhibits bruising, and rare bleeding. Precautions involve rare seizures,
starting dose for a CYP450 2D6, and mania, suicidal ideation, and sedation. Use caution in patients
medication, likely is metabolized by with seizure or bipolar disorders and monitor children and
an SSRI (Selective CYP450 3A4 and adolescents for suicidal ideation. Mild antihistamine effects may
Serotonin 2C19. cause sedation and fatigue. Consider risks versus benefits during
Reuptake pregnancy and breastfeeding.
Inhibitor).
Specifically:
Starting Dose: The
initial prescribed
dose is 20 mg/day.
Mechanism of
Action:
It blocks serotonin
and the serotonin
reuptake pump,
which prevents
serotonin from
, being reabsorbed
into the
presynaptic
neuron.
This action
desensitizes
serotonin
receptors,
reducing their
sensitivity over
time.
The overall effect
is to increase
serotonergic
neurotransmission,
enhancing the
availability and
activity of
serotonin in the
brain, which is
thought to
alleviate
symptoms of
depression and
anxiety.
Escitalopram This medication is The mean Common side effects include sexual dysfunction, decreased
(Lexapro) commonly terminal half-life appetite, nausea, vomiting, diarrhea, constipation, dry mouth,
prescribed for of this insomnia, agitation, tremors, headache, dizziness, sweating,
major depressive medication is 27- bruising, and rare bleeding. Precautions: Rare seizures, mania,
disorder (MDD), 32 hours. It is a activation of suicidal ideation, and sedation. Use caution with
Chamberlain College of Nursing
Antidepressant and Mood Stabilizer Medication Table
Week 5
Course: NR546/NR 546 Advanced
Pharmacology: Psychopharmacology
, THIS ASSIGNMENT SHOULD BE SUBMITTED TO THE WEEK 5 MEDICATION TABLE
Name Indication, starting Half-life (T1/2) Notes/Notable side effects/Precautions
dose, target CYP450 enzyme
symptoms, and
affected
neurotransmitters
SSRIs
Citalopram This selection The parent drug Notable side effects include sexual dysfunction, appetite
(Celexa) describes the has a half-life of changes, nausea, vomiting, diarrhea, constipation, dry mouth,
mechanism of 23-45 hours, insomnia, agitation, tremors, headache, dizziness, sweating,
action and weakly inhibits bruising, and rare bleeding. Precautions involve rare seizures,
starting dose for a CYP450 2D6, and mania, suicidal ideation, and sedation. Use caution in patients
medication, likely is metabolized by with seizure or bipolar disorders and monitor children and
an SSRI (Selective CYP450 3A4 and adolescents for suicidal ideation. Mild antihistamine effects may
Serotonin 2C19. cause sedation and fatigue. Consider risks versus benefits during
Reuptake pregnancy and breastfeeding.
Inhibitor).
Specifically:
Starting Dose: The
initial prescribed
dose is 20 mg/day.
Mechanism of
Action:
It blocks serotonin
and the serotonin
reuptake pump,
which prevents
serotonin from
, being reabsorbed
into the
presynaptic
neuron.
This action
desensitizes
serotonin
receptors,
reducing their
sensitivity over
time.
The overall effect
is to increase
serotonergic
neurotransmission,
enhancing the
availability and
activity of
serotonin in the
brain, which is
thought to
alleviate
symptoms of
depression and
anxiety.
Escitalopram This medication is The mean Common side effects include sexual dysfunction, decreased
(Lexapro) commonly terminal half-life appetite, nausea, vomiting, diarrhea, constipation, dry mouth,
prescribed for of this insomnia, agitation, tremors, headache, dizziness, sweating,
major depressive medication is 27- bruising, and rare bleeding. Precautions: Rare seizures, mania,
disorder (MDD), 32 hours. It is a activation of suicidal ideation, and sedation. Use caution with
