HERPES VIRUSES
, Bacteria Virus
1. Size >0.2μ (0.02-0.2)μ.
Larger Smaller
2. Cell wall/ Ribosome present absent
3. Enzyme present absent
for metabolism
4. Genome both DNA & RNA either DNA or RNA
5. Can be seen by seen not seen EM
ordinary microscope
6. Growth in cell culture No. Cultured in non Yes. Require living
& yolk sac living media host: Tissue culture,
7. Multiply by binary fission by replication
, HERPES VIRUS
• Outstanding characteristics
• Double Stranded DNA Enveloped virus
• Replicate in the nucleus
• Form intra-nuclear inclusion body
• Obtain envelopes by budding from nuclear membrane
• Establish Latent and recurrent infections
• Persist indefinitely in infected hosts
,
, Transmission
Transmitted in secretions and spread by close contact
HSV 1
• Present in vesicle fluid, saliva and
• Transmitted by oral contact (kissing), through sharing of
drinking glass, toothbrush, autoinoculation into eyes
HSV 2
• Spread by sexual contact; and infect genitalia, ano-rectal
tissue or oro-pharynx
• May be transmitted from an infected mother to her infant
at birth and results in disseminated and neurological
disease.
,Herpes simplex lesion of lower lip,
,
,Clinical Presentation of HSV 1 &HSV 2
, Comparison of HSV1 and HSV2
HSV1 HSV2
• Transmission-Saliva • Sexual contact
• Site of latency - • Lumber & Sacral
Trigeminal ganglia ganglia
• Age of primary infection • Young adults
– young children
• More common
• Recurrent infection –
less common • Usually bellow the
• Site of infection – waist
usually above the waist
, Bacteria Virus
1. Size >0.2μ (0.02-0.2)μ.
Larger Smaller
2. Cell wall/ Ribosome present absent
3. Enzyme present absent
for metabolism
4. Genome both DNA & RNA either DNA or RNA
5. Can be seen by seen not seen EM
ordinary microscope
6. Growth in cell culture No. Cultured in non Yes. Require living
& yolk sac living media host: Tissue culture,
7. Multiply by binary fission by replication
, HERPES VIRUS
• Outstanding characteristics
• Double Stranded DNA Enveloped virus
• Replicate in the nucleus
• Form intra-nuclear inclusion body
• Obtain envelopes by budding from nuclear membrane
• Establish Latent and recurrent infections
• Persist indefinitely in infected hosts
,
, Transmission
Transmitted in secretions and spread by close contact
HSV 1
• Present in vesicle fluid, saliva and
• Transmitted by oral contact (kissing), through sharing of
drinking glass, toothbrush, autoinoculation into eyes
HSV 2
• Spread by sexual contact; and infect genitalia, ano-rectal
tissue or oro-pharynx
• May be transmitted from an infected mother to her infant
at birth and results in disseminated and neurological
disease.
,Herpes simplex lesion of lower lip,
,
,Clinical Presentation of HSV 1 &HSV 2
, Comparison of HSV1 and HSV2
HSV1 HSV2
• Transmission-Saliva • Sexual contact
• Site of latency - • Lumber & Sacral
Trigeminal ganglia ganglia
• Age of primary infection • Young adults
– young children
• More common
• Recurrent infection –
less common • Usually bellow the
• Site of infection – waist
usually above the waist
