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Question 1
Which of the following A1C values is indicative of Diabetes Mellitus, according to the provided
information?
A) 5.5%
B) 6.0%
C) 6.4%
D) 6.5% or greater
E) 5.0%
Correct Answer: D) 6.5% or greater
Rationale: A1C value of 6.5% or greater is considered diabetes mellitus. Values between
5.7% and 6.4% indicate pre-diabetes.
Question 2
A patient presents with a fasting plasma glucose level of 130 mg/dL. Based on the provided
criteria, what does this value indicate?
A) Normal blood glucose
B) Pre-diabetes
C) Diabetes Mellitus
D) Hypoglycemia
E) Impaired glucose tolerance
Correct Answer: C) Diabetes Mellitus
Rationale: a fasting plasma glucose value of 126 mg/dL or greater indicates diabetes
mellitus. A value of 130 mg/dL falls into this diabetic range.
Question 3
Which two medications are specifically mentioned as being used to treat gestational diabetes?
A) Glyburide and Pioglitazone
B) Metformin and Insulin
C) Sitagliptin and Liraglutide
D) Acarbose and Repaglinide
E) Rosiglitazone and Glipizide
Correct Answer: B) Metformin and Insulin
Rationale: Metformin and Insulin are the drugs used to treat gestational diabetes.
Question 4
Which of the following is a common complication of insulin therapy characterized by an
accumulation of subcutaneous fat due to too frequent injections at the same site?
A) Hypokalemia
B) Allergic reactions
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C) Ketoacidosis
D) Lipohypertrophy
E) Hyperglycemia
Correct Answer: D) Lipohypertrophy
Rationale: Lipohypertrophy is described as an accumulation of subcutaneous fat that
occurs when insulin is injected too frequently at the same site. Hypokalemia and allergic
reactions are also complications of insulin therapy, but do not specifically involve fat
accumulation at injection sites.
Question 5
A patient on insulin therapy develops red, intensely itchy welts and difficulty breathing. This is
characteristic of what complication, which, if severe, may require a desensitization procedure?
A) Lipohypertrophy
B) Hypokalemia
C) Allergic reactions
D) Hypoglycemia
E) Localized pain at injection site
Correct Answer: C) Allergic reactions
Rationale: Allergic reactions to insulin are described as being characterized by red and
intensely itchy welts and difficulty breathing. If a severe allergy develops, a desensitization
procedure (small to larger doses) may be required.
Question 6
Insulin can lead to hypokalemia through which mechanism?
A) It promotes the renal excretion of potassium.
B) It inhibits potassium absorption from the gastrointestinal tract.
C) It promotes the uptake of potassium into cells by activating a membrane-bound enzyme.
D) It converts potassium into an inactive form.
E) It directly binds to potassium, reducing its free concentration.
Correct Answer: C) It promotes the uptake of potassium into cells by activating a
membrane-bound enzyme.
Rationale: Insulin promotes the uptake of potassium into cells. It activates a membrane-
bound enzyme, sodium-potassium ATPase, which pumps potassium into the cells and
sodium out, thus contributing to hypokalemia.
Question 7
Which class of medications can intensify the hypoglycemia induced by insulin?
A) Thiazide diuretics
B) Glucocorticoids
C) Sulfonylureas
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D) Sympathomimetics
E) Beta-blockers
Correct Answer: C) Sulfonylureas
Rationale: hypoglycemic agents such as sulfonylureas, glinides, and alcohol can intensify
the hypoglycemia induced by insulin. Thiazides, glucocorticoids, and sympathomimetics
are hyperglycemic agents.
Question 8
Beta-blockers have what two main effects on patients using insulin for diabetes management?
A) Enhance glycogenolysis and increase awareness of hypoglycemia.
B) Delay awareness of hypoglycemia and impair glycogenolysis.
C) Increase insulin release and prevent counter-regulatory responses.
D) Intensify the effects of hyperglycemia and promote glucose uptake.
E) Reduce the risk of lipohypertrophy and allergic reactions.
Correct Answer: B) Delay awareness of hypoglycemia and impair glycogenolysis.
Rationale: Beta-blockers delay awareness of and response to hypoglycemia by masking the
signs associated with sympathetic nervous system stimulation. They also impair
glycogenolysis, preventing the body's counter-regulatory response to low blood glucose.
Question 9
Besides treating diabetes mellitus, insulin has other therapeutic uses. Which of the following is
one such use?
A) Hypokalemia
B) Hypernatremia
C) Diagnosis of hyperthyroidism
D) Diabetic nephropathy
E) Hyperkalemia
Correct Answer: E) Hyperkalemia
Rationale: Other therapeutic uses of insulin mentioned include hyperkalemia (as it drives
potassium into cells), aid in diagnosis of GH deficiency, and diabetic ketoacidosis.
Question 10
A patient's insulin dosage must be precisely coordinated with their:
A) Protein intake.
B) Fat intake.
C) Carbohydrate intake.
D) Fluid intake.
E) Sodium intake.
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Correct Answer: C) Carbohydrate intake.
Rationale: insulin dosage must be coordinated with carbohydrate intake to match glucose
production from food.
Question 11
What is the recommended blood pressure goal for a diabetic patient?
A) 140/90 mmHg or less
B) 130/80 mmHg or less
C) Controlled, within normal 120/80 mmHg
D) 150/90 mmHg or less
E) 110/70 mmHg or less
Correct Answer: C) Controlled, within normal 120/80 mmHg
Rationale: The blood pressure goal for a diabetic patient is stated as "To be controlled,
within normal 120/80."
Question 12
Which class of medication can be given to decrease the risk of diabetic nephropathy?
A) Calcium channel blockers
B) Beta-blockers
C) Loop diuretics
D) ACE inhibitors or ARBs
E) Alpha-adrenergic agonists
Correct Answer: D) ACE inhibitors or ARBs
Rationale: ACE inhibitor or ARB can be given to decrease the risk of diabetic nephropathy.
Question 13
What role does exercise play in the treatment of both type 1 and type 2 diabetes mellitus?
A) Decreases cellular responsiveness to insulin and glucose tolerance.
B) Increases cellular responsiveness to insulin and increases glucose tolerance.
C) Has no significant impact on insulin sensitivity.
D) Primarily affects fat metabolism, not glucose.
E) Only beneficial for type 2 diabetes, not type 1.
Correct Answer: B) Increases cellular responsiveness to insulin and increases glucose
tolerance.
Rationale: Exercise increases cellular responsiveness to insulin and increases glucose
tolerance in both type 1 and type 2 diabetes mellitus. A recommendation of 150 minutes per
week of moderate-intensity exercise is given.
Question 14
In the 4-step approach to diabetes management, what is the initial intervention for Step 1 after
diagnosis?