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ATI Pharmacology Proctored Exam 2025 – Comprehensive Study Guide with Practice Questions, Correct Answers & Rationales

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This document provides a complete study resource for the 2025 ATI Pharmacology Proctored Exam, covering major drug classes, safe medication administration, adverse effects, therapeutic uses, and nursing considerations. It includes practice-style questions with correct answers and rationales to strengthen clinical judgment and reinforce pharmacology concepts aligned with ATI’s latest exam framework. The material is organized to support efficient review and thorough preparation for nursing students.

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ATI Pharmacology Proctored / Actual Exam Questions with Correct Answers &
Rationales / 2025

Terms in this set (406)


A provider prescribes A. One
phenobarbital for a client who
has a seizure disorder. The (Medications with long half-lives remain at their therapeutic levels
medication has a long half-life of between doses for long periods of time. The nurse should expect
4 days. How many times per day to administer this medication once a
day.)
should the nurse expect to
administer this medication?


A. One
B. Two
C. Three
D. Four

,A staff educator is reviewing C. Liver failure
medication dosages and E. Concurrent use of medication the same pathway metabolizes
factors that influence
medication metabolism with a group C. Liver failure decreases metabolism and thus increases the
of
concentration of a medication. This requires decreasing the
nurses at an in-service
dosage.
presentation. Which of the
following factors should the
E. When the same pathway metabolizes two medications, they compete for
educator include as a reason to
metabolism, thereby increasing the concentration of one or both
administer lower medication
medications. This requires decreasing the dosage of one or both
dosages? (Select all that apply.)


A. Increased renal secretion

B. Increased medication-

metabolizing enzymes
C. Liver failure

D. Peripheral vascular disease
E. Concurrent use of medication
the same pathway metabolizes



A nurse is preparing to B. Ask the client to look up at the ceiling.
administer eye drops to a client. D. Drop the medication into the center of the client's conjunctival sac.
Which of the following E. Instruct the client to close her eye gently after instillation
actions should the nurse take?
(B. The client should look upward to keep the drops from falling onto her
(Select all that apply.)
cornea.
D. The nurse should drop the medication into the
A. Have the client lie on her side.
center of the conjunctival sac to promote distribution.
B. Ask the client to look up at the
E. The client should close her eye gently to promote distribution of the
ceiling.
medication)
C. Tell the client to blink when

the drops enter her eye.
D. Drop the medication into the
center of the client's
conjunctival sac.
E. Instruct the client to close her eye
gently
after instillation

,A nurse is completing discharge C. "I will apply the patch to an area of skin with no hair."
teaching for a client who has a
new prescription for transdermal (The client should apply the patch to a hairless area of skin to
patches. Which of the promote absorption of the medication.)
following statements should
the nurse identify as an
indication that the client
understands the
instructions?


A. "I will clean the site with an

alcohol swab before I apply the
patch."
B. "I will rotate the application sites
weekly."
C. "I will apply the patch to an

area of skin with no hair."
D. "I will place the new patch on the
site of
the old patch.

, A nurse reviewing a client's A. Obtain a blood specimen immediately prior to administering the
medical record notes a new next dose of medication.
prescription for verifying the
trough level of the client's (To verify trough levels of a medication, the nurse should obtain a
medication. Which of the blood specimen immediately before administering the next dose
following actions should the of medication.)
nurse take?


A. Obtain a blood specimen
immediately prior to
administering the next dose of
medication.
B. Verify that the client has been

taking the medication for 24 hr
before obtaining a
blood specimen.
C. Ask the client to provide a

urine specimen after the
next dose of
medication.
D. Administer the medication,and
obtain a blood specimen 30
min late



A. Maintain skill competency.
A nurse is preparing a client's C. Monitor for adverse effects.
medications. Which of the D. Safeguard medications.
following actions should the
nurse take in following legal (A.maintaining skill competency and using appropriate

practice administration techniques are legal responsibilities of the nurse
guidelines? (Select all that apply.)
C. A nurse is legally responsible for monitoring for side and adverse
A. Maintain skill competency. effects of medication
B. Determine the dosage.

C. Monitor for adverse effects. D. Safeguarding of medications, such as controlled substances, is a
D. Safeguard medications.
legal responsibility of the nurse)
E. Identify the client's diagnosis

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