1|Page
HESI Pharmacology Practice Test (NEW UPDATED VERSION) LATEST
ACTUAL EXAM QUESTIONS AND CORRECT ANSWERS (VERIFIED QUESTIONS AND
ANSWERS) | GUARANTEED PASS A+ [2026-2027]
The nurse reviews the new prescription, phenelzine (Nardil), a monoamine oxidase
inhibitor (MAOI), for a client with depression on the psychiatric unit. Which information is
most important for the nurse to assess?
A. Consumption of any alcohol or tyramine rich foods
B. Reports of nausea or vomiting
C. Therapeutic serum drug levels
D. Blood pressure and pulse prior to taking each dose - CORRECT ANSWER A
QUESTION : The nurse is administering haloperidol 0.5 mg IM PRN to a client for the
first time. What side effects should the nurse assess thr client during the initial dose?
A. Bradykinesia
B. Dystonia
C. Somatization
D. Akathisia - CORRECT ANSWER B
QUESTION : While reviewing the client's electronic medical record (EMR), the nurse
assesses a client who is at risk for a possible interaction with an over-the-counter (OTC)
decongestant. Which client health history should the nurse report to the health care
provider concerning the OTC medication? (Select all that apply)
A. Type 1 diabetes mellitus (DM)
B. Closed angle glaucome
C. Chronic hypertension
D. Rheumatoid arthritis
E. Crohn's disease - CORRECT ANSWER B,C
QUESTION : A client prescribed ipratropium reports nausea, blurred vision,
headaches, and insomnia after using the inhaler. Which action should the nurse
implement first?
A. Withhold the medication and report symptoms and vital signs to the healthcare
provider
B. Give PRN medication for nausea and vomiting and evaluate client in 30 minutes
C. reassure client that the ipratropium given will alleviate the symptoms
2026 2027 GRADED A+
,2|Page
D. Delay administration of ipratropium until the next maintenance medication is
scheduled - CORRECT ANSWER A
QUESTION : A client diagnosed with multiple sclerosis is experiencing profound
weakness, blurry vision, and shooting pains in both legs. Which medication is
considered the best course of treatment for the nurse to administer?
A. High dose methylprednisolone intravenously
B. Baclofen three times a day
C. Broad spectrum antibiotic coverage orally
D. Immunomodulatory drug therapy periodically - CORRECT ANSWER A
QUESTION : The nurse administers 30 mL of lactulose for a client with stage 2 hepatic
encephalopathy. Which assessment finding would indicate the medication is being
therapeutic?
A. A decrease in blood ammonia levels
B. A softening in the stools
C. An increase in glucose absorption
D. A suppression of gut acidification - CORRECT ANSWER A
QUESTION : The nurse is teaching a client who is newly diagnosed with type 1
diabetes about neutral protamine Hagedor (NPH) insulin. Which statement by the client
indicates an understanding of how the medication works?
A. It facilitates the transport of glucose into the cells
B. It stimulates the function of beta cells in the pancreas
C. It increases the intracellular receptor site sensitivity
D. It delays the carbohydrate digestion and absorption - CORRECT ANSWER A
QUESTION : The nurse should withhold which medication if a client reports nausea,
vomiting, and diarrhea?
A. Colchicine (Mitigare, Colcrys)
B. Erythromycin (E-mycin)
C. Naproxen (Aleve, Naprosyn)
D. Labetolol (Normodyne) - CORRECT ANSWER A
QUESTION : A client newly prescribed esomeprazole for gastroesophageal reflux
disease (GERD) asks the nurse how the medication will help. Which is the best
explanation to provide the client?
A. It will promote rapid tissue healing
B. It will increase gastric emptying
C. It will improve esophageal peristalsis
2026 2027 GRADED A+
,3|Page
D. It will neutralize gastric secretions - CORRECT ANSWER A
QUESTION : A nurse is providing medication education for a client prescribed a beta-
blocking agent for treatment of glaucoma. Which statement by the client demonstrates
an understanding of the mechanism of the medication?
A. It inhibits the aqueous humor production
B. It enhances the aqueous humor outflow
C. It increases the intraocular pressure
D. It prevents extraocular infection - CORRECT ANSWER A
QUESTION : A nurse is planning a teaching session for a client newly prescribed a
miotic drug for the treatment of glaucoma. Which information should the nurse include in
the teaching session?
A. The medication enhances the aqueous humor outflow
B. The medication inhibits the aqueous humor production
C. The medication dilates the pupils
D. The medication prevents extraocular infection - CORRECT ANSWER A
QUESTION : The healthcare provider (HCP) prescribes a medication for an older adult
client who is reporting insomnia, and the HCP instructs the client to return in two weeks.
The nurse should question which prescription?
A Zolpidem (Ambien) 10 milligrams orally at bedtime
B. Eszopiclone (Lunesta) 10 milligrams orally at bedtime
C. Temazepam (Restoril) 7.5 milligrams orally at bedtime
D. Ramelteon (Rozerem) 8 milligrams orally at bedtime - CORRECT ANSWER B
QUESTION : A client is diagnosed with peptic ulcer disease and receives a prescription
for esomeprazole (Nexium) 20 mg capsule daily. When providing this client with
discharge teaching, the nurse should include which instruction?
A. Drink fluids between meals to relieve gastric distress
B. Monitor for an increase in blood pressure during therapy
C. Dissolve capsule contents in fruit juice for easier ingestion
D. Take at same time each day one hour before eating a meal - CORRECT
ANSWER D
QUESTION : A client receives a new prescription for ciprofloxacin (Cipro), a synthetic
quinolone. When teaching about this drug, which information in the client history
requires special emphasis by the nurse?
A. Snacks on dairy products such as yogurt or ice cream
B. Previously had a mild allergic reaction to a cephalosporin
2026 2027 GRADED A+
, 4|Page
C. Consumes alcoholic drinks occasionally on the weekends
D. works twenty hours a week as a lifeguard at the local pool - CORRECT ANSWER
D
QUESTION : The nurse administers the initial dose of a fentanyl (Duragesic)
transdermal patch to a client. Which assessment finding should the nurse use to
evaluate the effectiveness of the medication?
A. The absence of seizures
B. The increase in lactation
C. The presence of bowel sounds
D. The number on the numeric pain scale - CORRECT ANSWER D
QUESTION : Based on the blood culture and sensitivity results, the healthcare provider
prescribes an IV aminoglycoside antibiotic and discontinues the current prescription for
another broad spectrum antibiotic. The medication administration record indicates that
the client received the broad spectrum antibiotic two hours ago. Which action should the
nurse implement?
A. Obtain peak and trough serum levels so the aminoglycoside antibiotic can be initiated
B. Administer the initial dose of the aminoglycoside antibiotic as soon as possible
C. Withhold antibiotic administration until the healthcare provider clarifies the
prescriptions
D. Schedule the initial dose of the aminoglycoside antibiotic for the following day -
CORRECT ANSWER B
QUESTION : The nurse is providing medication teaching for a client who recently
received a prescription for clozapine (Clozaril). Which instruction should be included in
this client's teaching plan?
A. Avoid prolonged sun exposure
B. Rise slowly from a lying position
C. Do not eat any aged cheese
D. Take as needed for anxiety - CORRECT ANSWER B
QUESTION : A client receives a new prescription for nitroglycerin (Nitrostat) tablets.
Which instruction should the nurse include in this client's teaching?
A. Take the medication at least an hour before every meal
B. Monitor your pulse for 60 seconds before administration
C. Place under the tongue as needed every 5 minutes up to 3 times
D. REsume normal activities after chest pain relief is obtained - CORRECT
ANSWER C
2026 2027 GRADED A+
HESI Pharmacology Practice Test (NEW UPDATED VERSION) LATEST
ACTUAL EXAM QUESTIONS AND CORRECT ANSWERS (VERIFIED QUESTIONS AND
ANSWERS) | GUARANTEED PASS A+ [2026-2027]
The nurse reviews the new prescription, phenelzine (Nardil), a monoamine oxidase
inhibitor (MAOI), for a client with depression on the psychiatric unit. Which information is
most important for the nurse to assess?
A. Consumption of any alcohol or tyramine rich foods
B. Reports of nausea or vomiting
C. Therapeutic serum drug levels
D. Blood pressure and pulse prior to taking each dose - CORRECT ANSWER A
QUESTION : The nurse is administering haloperidol 0.5 mg IM PRN to a client for the
first time. What side effects should the nurse assess thr client during the initial dose?
A. Bradykinesia
B. Dystonia
C. Somatization
D. Akathisia - CORRECT ANSWER B
QUESTION : While reviewing the client's electronic medical record (EMR), the nurse
assesses a client who is at risk for a possible interaction with an over-the-counter (OTC)
decongestant. Which client health history should the nurse report to the health care
provider concerning the OTC medication? (Select all that apply)
A. Type 1 diabetes mellitus (DM)
B. Closed angle glaucome
C. Chronic hypertension
D. Rheumatoid arthritis
E. Crohn's disease - CORRECT ANSWER B,C
QUESTION : A client prescribed ipratropium reports nausea, blurred vision,
headaches, and insomnia after using the inhaler. Which action should the nurse
implement first?
A. Withhold the medication and report symptoms and vital signs to the healthcare
provider
B. Give PRN medication for nausea and vomiting and evaluate client in 30 minutes
C. reassure client that the ipratropium given will alleviate the symptoms
2026 2027 GRADED A+
,2|Page
D. Delay administration of ipratropium until the next maintenance medication is
scheduled - CORRECT ANSWER A
QUESTION : A client diagnosed with multiple sclerosis is experiencing profound
weakness, blurry vision, and shooting pains in both legs. Which medication is
considered the best course of treatment for the nurse to administer?
A. High dose methylprednisolone intravenously
B. Baclofen three times a day
C. Broad spectrum antibiotic coverage orally
D. Immunomodulatory drug therapy periodically - CORRECT ANSWER A
QUESTION : The nurse administers 30 mL of lactulose for a client with stage 2 hepatic
encephalopathy. Which assessment finding would indicate the medication is being
therapeutic?
A. A decrease in blood ammonia levels
B. A softening in the stools
C. An increase in glucose absorption
D. A suppression of gut acidification - CORRECT ANSWER A
QUESTION : The nurse is teaching a client who is newly diagnosed with type 1
diabetes about neutral protamine Hagedor (NPH) insulin. Which statement by the client
indicates an understanding of how the medication works?
A. It facilitates the transport of glucose into the cells
B. It stimulates the function of beta cells in the pancreas
C. It increases the intracellular receptor site sensitivity
D. It delays the carbohydrate digestion and absorption - CORRECT ANSWER A
QUESTION : The nurse should withhold which medication if a client reports nausea,
vomiting, and diarrhea?
A. Colchicine (Mitigare, Colcrys)
B. Erythromycin (E-mycin)
C. Naproxen (Aleve, Naprosyn)
D. Labetolol (Normodyne) - CORRECT ANSWER A
QUESTION : A client newly prescribed esomeprazole for gastroesophageal reflux
disease (GERD) asks the nurse how the medication will help. Which is the best
explanation to provide the client?
A. It will promote rapid tissue healing
B. It will increase gastric emptying
C. It will improve esophageal peristalsis
2026 2027 GRADED A+
,3|Page
D. It will neutralize gastric secretions - CORRECT ANSWER A
QUESTION : A nurse is providing medication education for a client prescribed a beta-
blocking agent for treatment of glaucoma. Which statement by the client demonstrates
an understanding of the mechanism of the medication?
A. It inhibits the aqueous humor production
B. It enhances the aqueous humor outflow
C. It increases the intraocular pressure
D. It prevents extraocular infection - CORRECT ANSWER A
QUESTION : A nurse is planning a teaching session for a client newly prescribed a
miotic drug for the treatment of glaucoma. Which information should the nurse include in
the teaching session?
A. The medication enhances the aqueous humor outflow
B. The medication inhibits the aqueous humor production
C. The medication dilates the pupils
D. The medication prevents extraocular infection - CORRECT ANSWER A
QUESTION : The healthcare provider (HCP) prescribes a medication for an older adult
client who is reporting insomnia, and the HCP instructs the client to return in two weeks.
The nurse should question which prescription?
A Zolpidem (Ambien) 10 milligrams orally at bedtime
B. Eszopiclone (Lunesta) 10 milligrams orally at bedtime
C. Temazepam (Restoril) 7.5 milligrams orally at bedtime
D. Ramelteon (Rozerem) 8 milligrams orally at bedtime - CORRECT ANSWER B
QUESTION : A client is diagnosed with peptic ulcer disease and receives a prescription
for esomeprazole (Nexium) 20 mg capsule daily. When providing this client with
discharge teaching, the nurse should include which instruction?
A. Drink fluids between meals to relieve gastric distress
B. Monitor for an increase in blood pressure during therapy
C. Dissolve capsule contents in fruit juice for easier ingestion
D. Take at same time each day one hour before eating a meal - CORRECT
ANSWER D
QUESTION : A client receives a new prescription for ciprofloxacin (Cipro), a synthetic
quinolone. When teaching about this drug, which information in the client history
requires special emphasis by the nurse?
A. Snacks on dairy products such as yogurt or ice cream
B. Previously had a mild allergic reaction to a cephalosporin
2026 2027 GRADED A+
, 4|Page
C. Consumes alcoholic drinks occasionally on the weekends
D. works twenty hours a week as a lifeguard at the local pool - CORRECT ANSWER
D
QUESTION : The nurse administers the initial dose of a fentanyl (Duragesic)
transdermal patch to a client. Which assessment finding should the nurse use to
evaluate the effectiveness of the medication?
A. The absence of seizures
B. The increase in lactation
C. The presence of bowel sounds
D. The number on the numeric pain scale - CORRECT ANSWER D
QUESTION : Based on the blood culture and sensitivity results, the healthcare provider
prescribes an IV aminoglycoside antibiotic and discontinues the current prescription for
another broad spectrum antibiotic. The medication administration record indicates that
the client received the broad spectrum antibiotic two hours ago. Which action should the
nurse implement?
A. Obtain peak and trough serum levels so the aminoglycoside antibiotic can be initiated
B. Administer the initial dose of the aminoglycoside antibiotic as soon as possible
C. Withhold antibiotic administration until the healthcare provider clarifies the
prescriptions
D. Schedule the initial dose of the aminoglycoside antibiotic for the following day -
CORRECT ANSWER B
QUESTION : The nurse is providing medication teaching for a client who recently
received a prescription for clozapine (Clozaril). Which instruction should be included in
this client's teaching plan?
A. Avoid prolonged sun exposure
B. Rise slowly from a lying position
C. Do not eat any aged cheese
D. Take as needed for anxiety - CORRECT ANSWER B
QUESTION : A client receives a new prescription for nitroglycerin (Nitrostat) tablets.
Which instruction should the nurse include in this client's teaching?
A. Take the medication at least an hour before every meal
B. Monitor your pulse for 60 seconds before administration
C. Place under the tongue as needed every 5 minutes up to 3 times
D. REsume normal activities after chest pain relief is obtained - CORRECT
ANSWER C
2026 2027 GRADED A+
