MCB 2000 (UCONN) Final Exam with
Complete Solutions 2025-2026 Edition.
B. The oxygen in water has a partial (+) charge
The oxygen has a partial (-) charge - Answer Water is a solvent for so many molecules. What
selection A through D DOES NOT apply to water's solvent properties?
A. The hydrogen in water acts as a hydrogen donor to form a hydrogen bond
B. The oxygen in water has a partial (+) charge
C. It can weaken electrostatic interactions that occur between other molecules/ions
D. The sharing of electrons between the oxygen and hydrogens in water is not equal
E. All apply
- Answer The following statements refer to pKa. Select the CORRECT statement
A. When pH is less than pKa a functional group is deprotonated
B. The higher the pKa value, the stronger the acid
C. The pKa of a glutamic acid side chain would decrease (compared to the pKa of glutamic acid
as a free amino acid) if it was located near the carboxy terminus in a protein's tertiary structure
D. A drug containing an ionizable group with pKa = 6.0 will be taken up to a lesser extent in
cancer cells than one with a pKa = 9.0 because cancer cells have a more acidic extracellular
environment
E. None of the above are incorrect (all apply)
C. buffer 3<buffer 2<buffer 1
Having more acid in a solution (ml) makes the pH lower and the ratios are respective - Answer
Three buffers are made by combining a 1M solution of acetic acid with a 1M solution of sodium
acetate in the ratios below:
Buffer 1: 25ml acetic acid 75ml sodium acetate
Buffer 2: 50ml acetic acid 50ml sodium acetate
Buffer 3: 75ml acetic acid 25ml sodium acetate
Which of the following is true regarding pH?
A. buffer 1= buffer 2 = buffer 3
, E. This problem cannot be solved without the pKa
D. Buffer 2
When there are equal part acid and base it will buffer both equally - Answer Three buffers
are made by combining a 1M solution of acetic acid with a 1M solution of sodium acetate in the
ratios below:
Buffer 1: 25ml acetic acid 75ml sodium acetate
Buffer 2: 50ml acetic acid 50ml sodium acetate
Buffer 3: 75ml acetic acid 25ml sodium acetate
Which of the buffers will be most effective?
A. buffer 1
B. buffer 1=2=3
C. buffer 3
D. Buffer 2
E. This problem cannot be solved without the pKa
A. aromatic ring
Around 280nm - Answer What structural property of amino acids permits the measurement
of protein concentration by UV light absorption?
A. aromatic ring
B. aliphatic chain
C. carboxyamide group
D. amide group
E. imidazole ring
B. A=glutamic acid, B=lysine - Answer Which of the amino acids would yield the titration
curve shown in (A) and (B) respectively?
A. A=aspartic acid, B=threonine
B. A=glutamic acid, B=lysine
C. A=histidine, B=lysine
Complete Solutions 2025-2026 Edition.
B. The oxygen in water has a partial (+) charge
The oxygen has a partial (-) charge - Answer Water is a solvent for so many molecules. What
selection A through D DOES NOT apply to water's solvent properties?
A. The hydrogen in water acts as a hydrogen donor to form a hydrogen bond
B. The oxygen in water has a partial (+) charge
C. It can weaken electrostatic interactions that occur between other molecules/ions
D. The sharing of electrons between the oxygen and hydrogens in water is not equal
E. All apply
- Answer The following statements refer to pKa. Select the CORRECT statement
A. When pH is less than pKa a functional group is deprotonated
B. The higher the pKa value, the stronger the acid
C. The pKa of a glutamic acid side chain would decrease (compared to the pKa of glutamic acid
as a free amino acid) if it was located near the carboxy terminus in a protein's tertiary structure
D. A drug containing an ionizable group with pKa = 6.0 will be taken up to a lesser extent in
cancer cells than one with a pKa = 9.0 because cancer cells have a more acidic extracellular
environment
E. None of the above are incorrect (all apply)
C. buffer 3<buffer 2<buffer 1
Having more acid in a solution (ml) makes the pH lower and the ratios are respective - Answer
Three buffers are made by combining a 1M solution of acetic acid with a 1M solution of sodium
acetate in the ratios below:
Buffer 1: 25ml acetic acid 75ml sodium acetate
Buffer 2: 50ml acetic acid 50ml sodium acetate
Buffer 3: 75ml acetic acid 25ml sodium acetate
Which of the following is true regarding pH?
A. buffer 1= buffer 2 = buffer 3
, E. This problem cannot be solved without the pKa
D. Buffer 2
When there are equal part acid and base it will buffer both equally - Answer Three buffers
are made by combining a 1M solution of acetic acid with a 1M solution of sodium acetate in the
ratios below:
Buffer 1: 25ml acetic acid 75ml sodium acetate
Buffer 2: 50ml acetic acid 50ml sodium acetate
Buffer 3: 75ml acetic acid 25ml sodium acetate
Which of the buffers will be most effective?
A. buffer 1
B. buffer 1=2=3
C. buffer 3
D. Buffer 2
E. This problem cannot be solved without the pKa
A. aromatic ring
Around 280nm - Answer What structural property of amino acids permits the measurement
of protein concentration by UV light absorption?
A. aromatic ring
B. aliphatic chain
C. carboxyamide group
D. amide group
E. imidazole ring
B. A=glutamic acid, B=lysine - Answer Which of the amino acids would yield the titration
curve shown in (A) and (B) respectively?
A. A=aspartic acid, B=threonine
B. A=glutamic acid, B=lysine
C. A=histidine, B=lysine
