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PCB 3063 GENETICS EXAM 1 DR. ZHANG QUESTIONS AND VERIFIED ANSWERS

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PCB 3063 GENETICS EXAM 1 DR. ZHANG QUESTIONS AND VERIFIED ANSWERS

Institution
PCB 3063
Course
PCB 3063

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Invisible sites where DNA synthesis begins. Many sites on each chromosome. To make
chromosome copies


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origins of replication




Found in birds, many snakes, moths, isopods, butterflies, amphibians, fishes. Female
ZW (heterogametic) Male ZZ (homogametic)


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ZZ-ZW Sex Determination

,Controlled mating is not possible
Long generation time: expect around 40 years to observe F2 generation
Family size is typically small


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Human Genetic Studies disadvantages




Females with a single X chromosome referred to as XO. Underdeveloped secondary
sex characteristics. Typically short, a low hairline, broad chest, folds of skin on the
neck. Intelligence is usually normal.


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Turner Syndrome




Double Helix structure of DNA discovered by Watson and Crick


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1950s




two eggs fertilized by two sperm from two men at about the same time (half-siblings)


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, Bi-paternal twins




MRNA to DNA


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Reverse Transcription




2 nearly identical chromosomes, inherited from parents


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Homologous Pair




Alleles at different loci separate independently of one another. Occurs in anaphase 1
of meiosis


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Principle of Independent Assortment (Mendel's second law)




Takes place over decades. In the fetus, primordial germ cells replicate DNA and pair
up homologous chromosomes for crossing over. Then meiosis arrests. In the adult,
oocyte (2n) resumes meiosis to segregate homologous chromosomes. Upon

, fertilization by sperm, the egg undergoes meiosis 2, segregating sister chromosomes
to become ovum (1n)


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Meiosis in Human Females




Full genome sequences determined: Bacteria, Yeast, Human, Animals, Plants


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Genomic Era (1995)




BB or Bb is a low risk (12%) of breast cancer, but bb is 60% risk. BRCA 1 phenotype is
not fully penetrant because you can be bb and still have non-cancerous cells in
breast.


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BRCA1 ex




Both sexes show similar frequencies. Tend to skip generations. heterozygote parents
do not show traits. May go several generations without appearance of the disease.
Penetrance and sex influence can complicate interpretation. ex. Tay-Sachs.
Homozygous recessive trait is most
frequent in mating between close
relatives -Consanguinity


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Institution
PCB 3063
Course
PCB 3063

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