MGY250 UNIT 6 QUIZ EXAM
QUESTIONS AND ANSWERS GRADED A+
2025/2026
According to Dr. Roth, the bottleneck with genome sequencing in terms of personalized
medicine is in:
Interpreting genomes
The cost of sequencing
Sequencing technology is not advanced enough
Not having enough genomes sequenced - ANS Interpreting genomes
The Human Genome Project:
Was created from Craig Venter's DNA alone
Used many cell types
Sequenced several individuals to generate a reference sequence
Was a solely Canadian project - ANS Sequenced several individuals to generate a reference
sequence
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, The method most likely to be used to test for a pathogenic allele at a well-known location such
as the BRCA1 gene would be:
Whole Genome Sequencing
Whole Exome Sequencing
Genotyping
RNA-sequencing - ANS Genotyping
Oftentimes the result of an experiment is considered statistically significant if the p-value is less
than 0.05 (0.05 is denoted alpha). For GWAS, the significance threshold is set to values more
like 10-7. This is because:
All statistical tests should set alpha to 10-7
GWAS is a very conservative test
When you are doing so many tests, like with GWAS, the probability of finding a significant result
by chance is very high, so the p-value is adjusted to avoid false negatives
When you are doing so many tests, like with GWAS, the probability of finding a significant result
by chance is very high, so the p-value is adjusted to avoid false positives - ANS When you are
doing so many tests, like with GWAS, the probability of finding a significant result by chance is
very high, so the p-value is adjusted to avoid false positives
The data from GWAS:
Indicate many suggestive loci that are part of the haplotype block associated with the variant
Indicate a locus that is associated with the variant
Reveal the variant that causes disease unambiguously
Indicates rare variants associated with disease - ANS Indicate many suggestive loci that are
part of the haplotype block associated with the variant
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
QUESTIONS AND ANSWERS GRADED A+
2025/2026
According to Dr. Roth, the bottleneck with genome sequencing in terms of personalized
medicine is in:
Interpreting genomes
The cost of sequencing
Sequencing technology is not advanced enough
Not having enough genomes sequenced - ANS Interpreting genomes
The Human Genome Project:
Was created from Craig Venter's DNA alone
Used many cell types
Sequenced several individuals to generate a reference sequence
Was a solely Canadian project - ANS Sequenced several individuals to generate a reference
sequence
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, The method most likely to be used to test for a pathogenic allele at a well-known location such
as the BRCA1 gene would be:
Whole Genome Sequencing
Whole Exome Sequencing
Genotyping
RNA-sequencing - ANS Genotyping
Oftentimes the result of an experiment is considered statistically significant if the p-value is less
than 0.05 (0.05 is denoted alpha). For GWAS, the significance threshold is set to values more
like 10-7. This is because:
All statistical tests should set alpha to 10-7
GWAS is a very conservative test
When you are doing so many tests, like with GWAS, the probability of finding a significant result
by chance is very high, so the p-value is adjusted to avoid false negatives
When you are doing so many tests, like with GWAS, the probability of finding a significant result
by chance is very high, so the p-value is adjusted to avoid false positives - ANS When you are
doing so many tests, like with GWAS, the probability of finding a significant result by chance is
very high, so the p-value is adjusted to avoid false positives
The data from GWAS:
Indicate many suggestive loci that are part of the haplotype block associated with the variant
Indicate a locus that is associated with the variant
Reveal the variant that causes disease unambiguously
Indicates rare variants associated with disease - ANS Indicate many suggestive loci that are
part of the haplotype block associated with the variant
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
