MGY250 UNIT 7 QUIZ EXAM
QUESTIONS AND ANSWERS GRADED A+
2025/2026
Which of the following are ways that tumours can be generated in mice (select all that apply):
Inoculating an immunocompetent mouse with human tumour cells
Genetically engineer a mouse with specific mutations to generate tumours
Treat a mouse with carcinogens to generate tumours
Inoculating an immunosuppressed mouse with human tumour cells - ANS Genetically
engineer a mouse with specific mutations to generate tumours
Treat a mouse with carcinogens to generate tumours
Inoculating an immunosuppressed mouse with human tumour cells
The policy of the American College of Medical Genetics and Genomics (ACMG) is to return
information on 56 medically actionable genes from any clinical whole genome/exome
sequencing endeavour. This is:
Less information than the Canadian College of Medical Geneticists recommends providing
More information than the Canadian College of Medical Geneticists recommends providing
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, The same as the recommendations made by the Canadian College of Medical Geneticists -
ANS More information than the Canadian College of Medical Geneticists recommends
providing
The term "secondary finding" has replaced "incidental finding" because:
The finding is actively analyzed from genomic data, not passively stumbled upon
They do not arise from an incident
There was confusion as to whether incidental findings were primary findings
The discovery can be made in seconds - ANS The finding is actively analyzed from genomic
data, not passively stumbled upon
There are two hotspot mutations in the enzyme PIK3CA that commonly occur in cancers like
breast cancer. These mutations:
Cause the enzyme PIK3CA to be locked in the "on" state, causing overproduction of the
messenger protein PIP3 which promotes tumour growth and survival
Are random and there is no knowledge of their function
Cause the enzyme PIK3CA to be locked in the "off" state, causing suppression of the messenger
molecule PIP3 which promotes tumour growth and survival
Prevent the binding of a drug to inhibit PIK3CA function, which causes cancer - ANS Cause
the enzyme PIK3CA to be locked in the "on" state, causing overproduction of the messenger
protein PIP3 which promotes tumour growth and survival
RB1 is a tumour suppressor gene and the RB pathway suppresses tumour growth. The RB
pathway can be shut down by:
Overexpression of RB1, or overexpression of an RB1 inhibitor like CDK4 or overexpression of the
protein that regulates CDK4, CDKN2A
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
QUESTIONS AND ANSWERS GRADED A+
2025/2026
Which of the following are ways that tumours can be generated in mice (select all that apply):
Inoculating an immunocompetent mouse with human tumour cells
Genetically engineer a mouse with specific mutations to generate tumours
Treat a mouse with carcinogens to generate tumours
Inoculating an immunosuppressed mouse with human tumour cells - ANS Genetically
engineer a mouse with specific mutations to generate tumours
Treat a mouse with carcinogens to generate tumours
Inoculating an immunosuppressed mouse with human tumour cells
The policy of the American College of Medical Genetics and Genomics (ACMG) is to return
information on 56 medically actionable genes from any clinical whole genome/exome
sequencing endeavour. This is:
Less information than the Canadian College of Medical Geneticists recommends providing
More information than the Canadian College of Medical Geneticists recommends providing
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, The same as the recommendations made by the Canadian College of Medical Geneticists -
ANS More information than the Canadian College of Medical Geneticists recommends
providing
The term "secondary finding" has replaced "incidental finding" because:
The finding is actively analyzed from genomic data, not passively stumbled upon
They do not arise from an incident
There was confusion as to whether incidental findings were primary findings
The discovery can be made in seconds - ANS The finding is actively analyzed from genomic
data, not passively stumbled upon
There are two hotspot mutations in the enzyme PIK3CA that commonly occur in cancers like
breast cancer. These mutations:
Cause the enzyme PIK3CA to be locked in the "on" state, causing overproduction of the
messenger protein PIP3 which promotes tumour growth and survival
Are random and there is no knowledge of their function
Cause the enzyme PIK3CA to be locked in the "off" state, causing suppression of the messenger
molecule PIP3 which promotes tumour growth and survival
Prevent the binding of a drug to inhibit PIK3CA function, which causes cancer - ANS Cause
the enzyme PIK3CA to be locked in the "on" state, causing overproduction of the messenger
protein PIP3 which promotes tumour growth and survival
RB1 is a tumour suppressor gene and the RB pathway suppresses tumour growth. The RB
pathway can be shut down by:
Overexpression of RB1, or overexpression of an RB1 inhibitor like CDK4 or overexpression of the
protein that regulates CDK4, CDKN2A
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
