MGY250 UNIT 9 QUIZ EXAM
QUESTIONS AND ANSWERS GRADED A+
2025/2026
Microsatellite instability analysis involves:
Examining tumour tissue microsatellite stability, which would suggest a mutation in APC
Examining tumour tissue microsatellite stability, which would suggest an error in mismatch
repair
The comparison of normal and tumour tissue to determine if tumour tissue has relatively high
levels of microsatellite instability, which would suggest an error in mismatch repair
The comparison of normal and tumour tissue to determine if tumour tissue has relatively high
levels of microsatellite instability, which would suggest a mutation in APC - ANS The
comparison of normal and tumour tissue to determine if tumour tissue has relatively high levels
of microsatellite instability, which would suggest an error in mismatch repair
When there is a nucleotide mismatch, the following typically occur(s):
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in DNA base
repair
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in RNA base
repair
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in cell cycle
arrest, leading to apoptosis (programmed cell death)
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in cell cycle
arrest, leading to damage repair - ANS It is recognized by MSH6 and MSH2, which recruit
MLH1 and PMS2 and results in DNA base repair
Chorionic villus sampling (CVS) has an error rate of ~2%. This is because:
The sample is taken from the placenta and sometimes an aneuploidy is present only in the
placenta and not in the fetus, and vice versa
The sample is taken from the amniotic fluid and sometimes an aneuploidy is present only in the
amniotic fluid and not in the fetus, and vice versa
The sample taken from the fetus is minimal and may not have enough information
The technology used to analyze CVS isn't as advanced - ANS The sample is taken from the
placenta and sometimes an aneuploidy is present only in the placenta and not in the fetus, and
vice versa
The causes of birth defects can be roughly broken down to the following causes:
Complex inheritance 20%, single gene mutations 25%, chromosomal imbalance 50%,
environmental teratogen 25%
Complex inheritance 20%, single gene mutations 25%, chromosomal imbalance 20%,
environmental teratogen 50%
Complex inheritance 5%, single gene mutations 50%, chromosomal imbalance 25%,
environmental teratogen 20%
Complex inheritance 50%, single gene mutations 20%, chromosomal imbalance 25%,
environmental teratogen 5% - ANS Complex inheritance 50%, single gene mutations 20%,
chromosomal imbalance 25%, environmental teratogen 5%
Which of the following statements are true? (select all that apply)
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
QUESTIONS AND ANSWERS GRADED A+
2025/2026
Microsatellite instability analysis involves:
Examining tumour tissue microsatellite stability, which would suggest a mutation in APC
Examining tumour tissue microsatellite stability, which would suggest an error in mismatch
repair
The comparison of normal and tumour tissue to determine if tumour tissue has relatively high
levels of microsatellite instability, which would suggest an error in mismatch repair
The comparison of normal and tumour tissue to determine if tumour tissue has relatively high
levels of microsatellite instability, which would suggest a mutation in APC - ANS The
comparison of normal and tumour tissue to determine if tumour tissue has relatively high levels
of microsatellite instability, which would suggest an error in mismatch repair
When there is a nucleotide mismatch, the following typically occur(s):
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in DNA base
repair
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in RNA base
repair
1 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
, It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in cell cycle
arrest, leading to apoptosis (programmed cell death)
It is recognized by MSH6 and MSH2, which recruit MLH1 and PMS2 and results in cell cycle
arrest, leading to damage repair - ANS It is recognized by MSH6 and MSH2, which recruit
MLH1 and PMS2 and results in DNA base repair
Chorionic villus sampling (CVS) has an error rate of ~2%. This is because:
The sample is taken from the placenta and sometimes an aneuploidy is present only in the
placenta and not in the fetus, and vice versa
The sample is taken from the amniotic fluid and sometimes an aneuploidy is present only in the
amniotic fluid and not in the fetus, and vice versa
The sample taken from the fetus is minimal and may not have enough information
The technology used to analyze CVS isn't as advanced - ANS The sample is taken from the
placenta and sometimes an aneuploidy is present only in the placenta and not in the fetus, and
vice versa
The causes of birth defects can be roughly broken down to the following causes:
Complex inheritance 20%, single gene mutations 25%, chromosomal imbalance 50%,
environmental teratogen 25%
Complex inheritance 20%, single gene mutations 25%, chromosomal imbalance 20%,
environmental teratogen 50%
Complex inheritance 5%, single gene mutations 50%, chromosomal imbalance 25%,
environmental teratogen 20%
Complex inheritance 50%, single gene mutations 20%, chromosomal imbalance 25%,
environmental teratogen 5% - ANS Complex inheritance 50%, single gene mutations 20%,
chromosomal imbalance 25%, environmental teratogen 5%
Which of the following statements are true? (select all that apply)
2 @COPYRIGHT 2025/2026 ALLRIGHTS RESERVED.
