MARYVILLE NURS 663 EXAM 1/ STUDY GUIDE
WITH COMPLETE SOLUTIONS.
SIADH - correct answersSyndrome of inappropriate antidiuretic hormone
secretion (SIADH) is a condition in which the body makes too much antidiuretic
hormone (ADH). This hormone helps the kidneys control the amount of water
your body loses through the urine. SIADH causes the body to retain too much
water
Causes of SIADH - correct answers
Carbamazepine (Tegretol)
Is primarily metabolized by ______ (cytochrome P450) - correct answersIs
primarily metabolized by cytochrome P450 3A4
HORRIBLE D/T DRUG-DRUG INTERACTIONS
ANTICONVULSANT
•First line agent for acute mania and mania prophylaxis
•Indicated for rapid cyclers and mixed patients
Carbamazepine (Tegretol)
LABS and DOSAGE - correct answers•Before med is started: baseline LIVER
function tests, CBC, THYROID, KIDNEY, PREGNANCY and an EKG
•Monitoring: Steady state achieved after 5 days -check 12 hours after last dose
and repeat CBC and LFT
•Goal: Target levels 4-12mcg/ml
400-1200 mg/day
•Need to check level and adjust dosing after around a month because induces
own metabolism.
Escitalopram (Lexapro) - correct answersSSRI (NEUTRAL), MDD, GAD
•Pros
-Low overall inhibition of P450s enzymes so fewer drug-drug interactions
-Intermediate 1/2 life
-More effective than Citalopram in acute response and remission
•Cons
-Dose-dependent QT interval prolongation with doses of 10-30mg daily
WITH COMPLETE SOLUTIONS.
SIADH - correct answersSyndrome of inappropriate antidiuretic hormone
secretion (SIADH) is a condition in which the body makes too much antidiuretic
hormone (ADH). This hormone helps the kidneys control the amount of water
your body loses through the urine. SIADH causes the body to retain too much
water
Causes of SIADH - correct answers
Carbamazepine (Tegretol)
Is primarily metabolized by ______ (cytochrome P450) - correct answersIs
primarily metabolized by cytochrome P450 3A4
HORRIBLE D/T DRUG-DRUG INTERACTIONS
ANTICONVULSANT
•First line agent for acute mania and mania prophylaxis
•Indicated for rapid cyclers and mixed patients
Carbamazepine (Tegretol)
LABS and DOSAGE - correct answers•Before med is started: baseline LIVER
function tests, CBC, THYROID, KIDNEY, PREGNANCY and an EKG
•Monitoring: Steady state achieved after 5 days -check 12 hours after last dose
and repeat CBC and LFT
•Goal: Target levels 4-12mcg/ml
400-1200 mg/day
•Need to check level and adjust dosing after around a month because induces
own metabolism.
Escitalopram (Lexapro) - correct answersSSRI (NEUTRAL), MDD, GAD
•Pros
-Low overall inhibition of P450s enzymes so fewer drug-drug interactions
-Intermediate 1/2 life
-More effective than Citalopram in acute response and remission
•Cons
-Dose-dependent QT interval prolongation with doses of 10-30mg daily
