Antimicrobialmockquiz
Advanced Pharmacology for Nurse Practitioners
(The University of Texas at Arlington)
, MOCK TEST: Antimicrobial Agents
QUESTIONS
1. Which of the following antibiotics is most associated with tendon rupture?
A. Amoxicillin
B. Ciprofloxacin
C. Ceftriaxone
D. Clindamycin
2. What is the mechanism of action of aminoglycosides like gentamicin?
A. Inhibit folic acid synthesis
B. Inhibit DNA gyrase
C. Bind to 30S subunit causing mRNA misreading
D. Inhibit peptidoglycan synthesis
3. Which drug is contraindicated in patients with G6PD deficiency due to hemolytic anemia risk?
A. Metronidazole
B. Nitrofurantoin
C. Azithromycin
D. Cefazolin
4. Which of the following is true regarding vancomycin for C. difficile infection?
A. Only given IV
B. Has high systemic absorption
C. Oral route is effective for C. diff
D. Inhibits DNA gyrase
5. What class does linezolid belong to?
A. Macrolide
B. Oxazolidinone
C. Fluoroquinolone
D. Carbapenem
6. A key adverse effect of tetracyclines is:
A. Tendon rupture
B. Red man syndrome
C. Teeth discoloration
D. Seizures
7. What is the black box warning for tigecycline (Tygacil)?
A. Optic neuritis
B. Increased risk of death
C. Thrombocytopenia
D. Tendon rupture
, 8. Which of the following drugs is used only for C. difficile and has minimal
systemic absorption?
A. Metronidazole
B. Vancomycin (IV)
C. Fidaxomicin
D. Ceftriaxone
9. Which drug class inhibits RNA polymerase?
A. Fluoroquinolones
B. Rifamycins
C. Beta-lactams
D. Macrolides
10. Which of the following is a time-dependent killer and works best when above MIC?
A. Aminoglycosides
B. Fluoroquinolones
C. Beta-lactams
D. Metronidazole
11. What lab monitoring is most important for a patient receiving aminoglycosides?
A. LFTs
B. TSH
C. Renal function
D. Platelets
12. Which of the following is most associated with ototoxicity and nephrotoxicity?
A. Chloramphenicol
B. Gentamicin
C. Clarithromycin
D. Metronidazole
13. Which macrolide has the least CYP interactions?
A. Erythromycin
B. Clarithromycin
C. Azithromycin
D. Fidaxomicin
14. What is a unique adverse effect of chloramphenicol?
A. QT prolongation
B. Gray baby syndrome
C. Red man syndrome
D. Bone discoloration
15. Which antifungal requires pre-hydration to prevent nephrotoxicity?
A. Fluconazole
B. Caspofungin
Advanced Pharmacology for Nurse Practitioners
(The University of Texas at Arlington)
, MOCK TEST: Antimicrobial Agents
QUESTIONS
1. Which of the following antibiotics is most associated with tendon rupture?
A. Amoxicillin
B. Ciprofloxacin
C. Ceftriaxone
D. Clindamycin
2. What is the mechanism of action of aminoglycosides like gentamicin?
A. Inhibit folic acid synthesis
B. Inhibit DNA gyrase
C. Bind to 30S subunit causing mRNA misreading
D. Inhibit peptidoglycan synthesis
3. Which drug is contraindicated in patients with G6PD deficiency due to hemolytic anemia risk?
A. Metronidazole
B. Nitrofurantoin
C. Azithromycin
D. Cefazolin
4. Which of the following is true regarding vancomycin for C. difficile infection?
A. Only given IV
B. Has high systemic absorption
C. Oral route is effective for C. diff
D. Inhibits DNA gyrase
5. What class does linezolid belong to?
A. Macrolide
B. Oxazolidinone
C. Fluoroquinolone
D. Carbapenem
6. A key adverse effect of tetracyclines is:
A. Tendon rupture
B. Red man syndrome
C. Teeth discoloration
D. Seizures
7. What is the black box warning for tigecycline (Tygacil)?
A. Optic neuritis
B. Increased risk of death
C. Thrombocytopenia
D. Tendon rupture
, 8. Which of the following drugs is used only for C. difficile and has minimal
systemic absorption?
A. Metronidazole
B. Vancomycin (IV)
C. Fidaxomicin
D. Ceftriaxone
9. Which drug class inhibits RNA polymerase?
A. Fluoroquinolones
B. Rifamycins
C. Beta-lactams
D. Macrolides
10. Which of the following is a time-dependent killer and works best when above MIC?
A. Aminoglycosides
B. Fluoroquinolones
C. Beta-lactams
D. Metronidazole
11. What lab monitoring is most important for a patient receiving aminoglycosides?
A. LFTs
B. TSH
C. Renal function
D. Platelets
12. Which of the following is most associated with ototoxicity and nephrotoxicity?
A. Chloramphenicol
B. Gentamicin
C. Clarithromycin
D. Metronidazole
13. Which macrolide has the least CYP interactions?
A. Erythromycin
B. Clarithromycin
C. Azithromycin
D. Fidaxomicin
14. What is a unique adverse effect of chloramphenicol?
A. QT prolongation
B. Gray baby syndrome
C. Red man syndrome
D. Bone discoloration
15. Which antifungal requires pre-hydration to prevent nephrotoxicity?
A. Fluconazole
B. Caspofungin
