HESI Pathophysiology Exam 2024–2025 –
Nursing HESI Preparation | 1270 Practice
Questions with Verified Answers
Introduction:
This document contains 1270 comprehensive HESI
Pathophysiology practice questions with verified answers,
covering major body systems, disease processes, immune
responses, fluid and electrolyte imbalances, and clinical
manifestations. It is designed to support nursing students
preparing for the HESI Pathophysiology exam during the
2024–2025 academic year and aligns closely with typical HESI
exam content and question style.
Exam Questions and Verified Answers:
When caring for a patient with a chest tube drainage system,
the nurse observes continuous bubbling in the water seal
chamber. What action should the nurse take first?
A) Clamp the chest tube
B) Increase the suction pressure
C) Check for a leak in the system
D) Notify the healthcare provider immediately -Answer:-c)
check for a leak in the system
,While auscultating the lungs of a patient, the nurse hears high-
pitched, musical sounds during inspiration. Which condition
should the nurse suspect?
A) Pleural effusion
B) Atelectasis
C) Bronchitis
D) Wheezes -Answer:-d) wheezes
Which action by the nurse is most appropriate when
administering oxygen therapy to a patient with chronic
hypoxemia?
A) Using a non-rebreather mask at 15 L/min
B) Maintaining an oxygen saturation (SpO2) of 95%
C) Adjusting the oxygen flow rate based on the patient's
preference
D) Administering oxygen via a nasal cannula at 2 L/min -
Answer:-b) maintaining an oxygen saturation of 95%
The chest X-ray of a patient reveals an area of increased
density in the left lower lobe with air bronchograms. Which
condition is consistent with this finding?
,A) Atelectasis
B) Pneumonia
C) Pulmonary embolism
D) Pleural effusion -Answer:-b) pneumonia
A 2-month-old infant is brought to the pediatrician's office for
a routine check-up. Which immunization should the nurse
prioritize administering during this visit?
A) Varicella (chickenpox)
B) Hepatitis B
C) Mumps, measles, and rubella (MMR)
D) Influenza -Answer:-b) hep B
Which statement best describes the role of T cells in the
immune response?
A) T cells produce antibodies to neutralize pathogens.
B) T cells directly phagocytose invading pathogens.
C) T cells recognize antigens and activate other immune cells.
D) T cells release histamine to initiate inflammation. -
Answer:-c) T cells recognize antigens and activate other
immune cells
, A patient presents with joint pain, fatigue, and a butterfly-
shaped rash across the cheeks. Based on these symptoms,
which autoimmune disorder should the nurse suspect?
A) Rheumatoid arthritis
B) Systemic lupus erythematosus (SLE)
C) Multiple sclerosis (MS)
D) Type 1 diabetes mellitus -Answer:-b) Systemic lupus
erythematosus (SLE)
A patient reports swelling of the lips, tongue, and throat after
consuming peanuts. Which type of hypersensitivity reaction
should the nurse suspect?
A) Type I
B) Type II
C) Type III
D) Type IV -Answer:-A) type I
When educating a group of adolescents about HIV
transmission, which statement by the nurse is correct?
A) "HIV can be transmitted through casual contact like sharing
utensils."
Nursing HESI Preparation | 1270 Practice
Questions with Verified Answers
Introduction:
This document contains 1270 comprehensive HESI
Pathophysiology practice questions with verified answers,
covering major body systems, disease processes, immune
responses, fluid and electrolyte imbalances, and clinical
manifestations. It is designed to support nursing students
preparing for the HESI Pathophysiology exam during the
2024–2025 academic year and aligns closely with typical HESI
exam content and question style.
Exam Questions and Verified Answers:
When caring for a patient with a chest tube drainage system,
the nurse observes continuous bubbling in the water seal
chamber. What action should the nurse take first?
A) Clamp the chest tube
B) Increase the suction pressure
C) Check for a leak in the system
D) Notify the healthcare provider immediately -Answer:-c)
check for a leak in the system
,While auscultating the lungs of a patient, the nurse hears high-
pitched, musical sounds during inspiration. Which condition
should the nurse suspect?
A) Pleural effusion
B) Atelectasis
C) Bronchitis
D) Wheezes -Answer:-d) wheezes
Which action by the nurse is most appropriate when
administering oxygen therapy to a patient with chronic
hypoxemia?
A) Using a non-rebreather mask at 15 L/min
B) Maintaining an oxygen saturation (SpO2) of 95%
C) Adjusting the oxygen flow rate based on the patient's
preference
D) Administering oxygen via a nasal cannula at 2 L/min -
Answer:-b) maintaining an oxygen saturation of 95%
The chest X-ray of a patient reveals an area of increased
density in the left lower lobe with air bronchograms. Which
condition is consistent with this finding?
,A) Atelectasis
B) Pneumonia
C) Pulmonary embolism
D) Pleural effusion -Answer:-b) pneumonia
A 2-month-old infant is brought to the pediatrician's office for
a routine check-up. Which immunization should the nurse
prioritize administering during this visit?
A) Varicella (chickenpox)
B) Hepatitis B
C) Mumps, measles, and rubella (MMR)
D) Influenza -Answer:-b) hep B
Which statement best describes the role of T cells in the
immune response?
A) T cells produce antibodies to neutralize pathogens.
B) T cells directly phagocytose invading pathogens.
C) T cells recognize antigens and activate other immune cells.
D) T cells release histamine to initiate inflammation. -
Answer:-c) T cells recognize antigens and activate other
immune cells
, A patient presents with joint pain, fatigue, and a butterfly-
shaped rash across the cheeks. Based on these symptoms,
which autoimmune disorder should the nurse suspect?
A) Rheumatoid arthritis
B) Systemic lupus erythematosus (SLE)
C) Multiple sclerosis (MS)
D) Type 1 diabetes mellitus -Answer:-b) Systemic lupus
erythematosus (SLE)
A patient reports swelling of the lips, tongue, and throat after
consuming peanuts. Which type of hypersensitivity reaction
should the nurse suspect?
A) Type I
B) Type II
C) Type III
D) Type IV -Answer:-A) type I
When educating a group of adolescents about HIV
transmission, which statement by the nurse is correct?
A) "HIV can be transmitted through casual contact like sharing
utensils."
