NBME CBSE latest 2026 ACTUAL EXAM T WITH
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ANSWERS (100% VERIFIED ANSWERS)||VERIFIED
EXAM!! (USMLE STEP 1) MEDICAL
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62 year old woman - osteoporosis - a bisphosphonate is
prescribed. The expected beneficial effect of the drug is
due to which of the following? - Answer-Decreased
Osteoclast Activity
Cohot Study of elderly women - relative risk ratio for hip
fractures among those who exercise regularly is 1.2 (95%
confidence interval of 1.1 to 1.8). Which of the following is
the conclusion about the effect of exercise on the risk of
hip fracture? - Answer-Statistically Significant Overall
Increase Risk
52 year old man goes to ER with chest pain radiating to
his jaw while shoveling snow. Pulse is 80/min and blood
pressure is 130/70. The most immediate treatment
mechanism of action? - Answer-Increased nitric oxide
concentration
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24 year old woman - spilled hot grease on her left leg
while working at a fast-food restaurant. Exam of leg shows
7cm pink, soft, granular, edematous wound. The formation
of this tissue was most likely caused by increased activity
of which? - Answer-a. Vascular Endothelial Growth Factor
VEGF - stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels - early wound repair
27 year old man- MVC - skull x-ray shows a linear,
nondepressed basal skull fracture - increased serum osm
and decreased urin osm. Following desmopressin urine
osm increases. Desmopressin's effect is due to the
activation of which of the following? - Answer-a. Adenylyl
Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A --
Ca
v2
A 10 month old boy - 4 day history of fever and cough. He
attends day care center. Chest exam shows intercostal
retractions along with bilateral, diffuse wheezes and
expiratory rhonchi. The infectious agent most likely has
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which of the following properties? - Answer-Mediation of
Cell Entry via a fusion protein
A 17 year old girl in ED - 15 minutes after being stung by a
bee. Mild light headedness but no difficulty swallowing-
Bilateral wheezing - Which is most appropriate
pharmacotherapy for this patient? - Answer-B2- Agonist
14 year old boy - 2 day history of sore throat and fever that
peaks in late afternoon. 1 week of fatigue. He recentaly
had sex with one partner. Physical exam show cervical
lymphadenopathy and pharyngeal erythema with a creamy
exudate. DX? - Answer-Infectious Mononucleosis
57 year old man - radiation therapy for squamous cell
carcinoma of the lung. Despite therapy, tumor increases in
size and he dies 6 months later. The progressive tumor
growth is due to a defect in cell cycle arrest in which of the
following phases of cell cycle? - Answer-G1
28 year old - lived in sub-Saharan Africa - until he came to
the US. Temp of 100.4 - imaging shows bilateral
hydroureter and hydronephrosis. Biopsy shows marked
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fibrosis and scattered granulomas. DX? - Answer-
Schistosomiasis
A couple with a family history of a-thalassemia. Woman
has one gene deletion and man has two gene deletion. If
the two gene is trans - what percentage of offspring will
have a two gene deletion? - Answer-50%
previously healthy 40 year brought to emergency
department by her husband - 2 day history of fever,
lethargy, confusion. PE shows scattered petechiae and
ecchymoses over the lower extremities - 3+ polychromasia
and 3+ schistocytes and Low platelets Dx? - Answer-
Thrombotic Thrombocytopenia Purpura
16 year old boy - is admitted to the ER because of a knife
wound to the left side of his chest. An X-ray of the chest
shows an air-fluid level in the left side of the chest, partial
collapse of the left lung, and the elevation of the stomach
bubble. The mediastinum is midline. DX? - Answer-
Hemopneumpothorax under tension
49 year old woman - coronary artery disease - BP 140/90 -
High Cholesterol, High LDL (190), High triglycerides (350)