Page 1 of 163
WGU D115 MASTER SET ADVANCED
PATHOPHYSIOLOGY FOR THE ADVANCED
PRACTICE NURSE EXAM 2026/2027 BANK
COMPLETE CURRENT TESTING QUESTION AND
DETAILED CORRECT ANSWER (VERIFIED)
GUARANTEED PASS/TOP-RATED A+.
WGU D115
Maximize your success on the WGU D115 Master Set exam with
focused preparation that strengthens your understanding of
complex disease mechanisms, system-specific
pathophysiology, and clinical manifestations for advanced
nursing practice. This resource is specifically designed for the
Advanced Pathophysiology course to prepare advanced practice
nurses for clinical decision-making and certification readiness.
Which type of genetic disease affects males more frequently
than females? ...... ANSWER ....... Sex-Linked recessive.
Since males only have one X and one Y, if the affected
chromosome has the illness, it will be expressed.
In which two conditions are chromosomal abnormalities the
leading known cause? ...... ANSWER ....... Intellectual
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disability and fetal miscarriage. Chromosome
abnormalities are the leading known cause of intellectual
disability and fetal miscarriage.
What are three examples of prenatal diagnostic studies?
...... ANSWER ....... Chorionic villus sampling (CVS),
amniocentesis, and preimplantation genetic testing (PGT)
are examples of prenatal diagnostic studies and are
performed in vitro. CVS is a form of genetic testing that
provides genetic information found in utero and is usually
performed between weeks 11 and 14 of pregnancy. An
amniocentesis is a form of genetic testing that evaluates
amniotic fluid and is usually performed during the
second trimester, between weeks 15 and 20 of
pregnancy. PGT is performed on the embryo prior to
implantation.
Which genetic disorder is characterized by the presence of a
zygote having one chromosome with a normal complement
of genes and one chromosome with a missing gene? ......
ANSWER ....... Cri du chat syndrome (translated as "cry
of the cat") is caused by a DNA deletion. This term
describes the cry often heard from a baby affected by the
syndrome. Cri du chat syndrome can present as a
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microcephalic, low birth-weight baby with a piercing cry.
How can an X-linked recessive disease skip generations?
...... ANSWER ....... The disease can be transmitted
through female carriers.
Since females have two copies of the X chromosome, the
mother may provide an unaffected X to a daughter or son.
Furthermore, a daughter may not show signs of the disease
because she has the other X (the only X the father can give to
a female) to cancel it out.
Which type of risk is referred to as the ratio of the disease
rate among the entire population to the disease rate in an
unexposed population? ...... ANSWER ....... Relative risk
is a ratio of probability, not an actual occurrence of
disease.
What are the empirical risks for most multifactorial diseases
based on? ...... ANSWER ....... Many factors from
lifestyle to genetics affect multifactorial diseases.
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Observation and evaluation of each case individually
provides the most thorough and accurate assessment.
What refers to the silenced gene of a gene pair. ......
ANSWER ....... The imprinted gene is the silent gene of a
gene pair.
What is the primary reason that some older adults have
impaired inflammation and wound healing? ...... ANSWER
....... The underlying chronic illness exists.
A generalized inflammatory response seen in chronic
illness depletes the body's reserves to fight against
illness.
Which cells are the body's primary defense against parasite
invasion? ...... ANSWER ....... Eosinophils are the body's
primary defense against parasites.
What Phagocytes bacteria? ...... ANSWER .......
Macrophages work by eating or phagocytosing bacteria.
WGU D115 MASTER SET ADVANCED
PATHOPHYSIOLOGY FOR THE ADVANCED
PRACTICE NURSE EXAM 2026/2027 BANK
COMPLETE CURRENT TESTING QUESTION AND
DETAILED CORRECT ANSWER (VERIFIED)
GUARANTEED PASS/TOP-RATED A+.
WGU D115
Maximize your success on the WGU D115 Master Set exam with
focused preparation that strengthens your understanding of
complex disease mechanisms, system-specific
pathophysiology, and clinical manifestations for advanced
nursing practice. This resource is specifically designed for the
Advanced Pathophysiology course to prepare advanced practice
nurses for clinical decision-making and certification readiness.
Which type of genetic disease affects males more frequently
than females? ...... ANSWER ....... Sex-Linked recessive.
Since males only have one X and one Y, if the affected
chromosome has the illness, it will be expressed.
In which two conditions are chromosomal abnormalities the
leading known cause? ...... ANSWER ....... Intellectual
, Page 2 of 163
disability and fetal miscarriage. Chromosome
abnormalities are the leading known cause of intellectual
disability and fetal miscarriage.
What are three examples of prenatal diagnostic studies?
...... ANSWER ....... Chorionic villus sampling (CVS),
amniocentesis, and preimplantation genetic testing (PGT)
are examples of prenatal diagnostic studies and are
performed in vitro. CVS is a form of genetic testing that
provides genetic information found in utero and is usually
performed between weeks 11 and 14 of pregnancy. An
amniocentesis is a form of genetic testing that evaluates
amniotic fluid and is usually performed during the
second trimester, between weeks 15 and 20 of
pregnancy. PGT is performed on the embryo prior to
implantation.
Which genetic disorder is characterized by the presence of a
zygote having one chromosome with a normal complement
of genes and one chromosome with a missing gene? ......
ANSWER ....... Cri du chat syndrome (translated as "cry
of the cat") is caused by a DNA deletion. This term
describes the cry often heard from a baby affected by the
syndrome. Cri du chat syndrome can present as a
, Page 3 of 163
microcephalic, low birth-weight baby with a piercing cry.
How can an X-linked recessive disease skip generations?
...... ANSWER ....... The disease can be transmitted
through female carriers.
Since females have two copies of the X chromosome, the
mother may provide an unaffected X to a daughter or son.
Furthermore, a daughter may not show signs of the disease
because she has the other X (the only X the father can give to
a female) to cancel it out.
Which type of risk is referred to as the ratio of the disease
rate among the entire population to the disease rate in an
unexposed population? ...... ANSWER ....... Relative risk
is a ratio of probability, not an actual occurrence of
disease.
What are the empirical risks for most multifactorial diseases
based on? ...... ANSWER ....... Many factors from
lifestyle to genetics affect multifactorial diseases.
, Page 4 of 163
Observation and evaluation of each case individually
provides the most thorough and accurate assessment.
What refers to the silenced gene of a gene pair. ......
ANSWER ....... The imprinted gene is the silent gene of a
gene pair.
What is the primary reason that some older adults have
impaired inflammation and wound healing? ...... ANSWER
....... The underlying chronic illness exists.
A generalized inflammatory response seen in chronic
illness depletes the body's reserves to fight against
illness.
Which cells are the body's primary defense against parasite
invasion? ...... ANSWER ....... Eosinophils are the body's
primary defense against parasites.
What Phagocytes bacteria? ...... ANSWER .......
Macrophages work by eating or phagocytosing bacteria.
