You are trying to cure diabetes by engineering pancreatic alpha cells to produce
insulin. What approach is likely to be successful?
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Create alpha cells that transcribe and translate the PDX-1 protein
How do TADs insulate genes?
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They physically ensure that promoters for a gene interact only with the
enhancers (CREs) for that gene
,Arrangement of genes on chromosomes
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Genes can be on either strand, with transcription oriented in different
directions; genes can overlap - all or parts of adjacent genes can be
present between exons and CREs
______ can regulate gene expression by inhibiting transcription while _____ can regulate
gene expression by blocking translation
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Deacetylation; miRISC
What would you predict about an organism with a very compact genome compared
to one with a less compact genome?
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It has less complex gene regulation
Every cell in our body has the same...
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, Genome (set of genes)
Two types of transposons
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Retrotransposons and DNA transposons
How do TFs bind enhancers and promoters at the same time?
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DNA between the enhancers and promoters bends
Cis-regulatory elements
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DNA sequences on the same piece of DNA as a gene that regulates
transcription of the gene (ex: enhancers and promoters)
All of the DNA in your body straightened out and laid end to end would reach from
here to...
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insulin. What approach is likely to be successful?
Give this one a try later!
Create alpha cells that transcribe and translate the PDX-1 protein
How do TADs insulate genes?
Give this one a try later!
They physically ensure that promoters for a gene interact only with the
enhancers (CREs) for that gene
,Arrangement of genes on chromosomes
Give this one a try later!
Genes can be on either strand, with transcription oriented in different
directions; genes can overlap - all or parts of adjacent genes can be
present between exons and CREs
______ can regulate gene expression by inhibiting transcription while _____ can regulate
gene expression by blocking translation
Give this one a try later!
Deacetylation; miRISC
What would you predict about an organism with a very compact genome compared
to one with a less compact genome?
Give this one a try later!
It has less complex gene regulation
Every cell in our body has the same...
Give this one a try later!
, Genome (set of genes)
Two types of transposons
Give this one a try later!
Retrotransposons and DNA transposons
How do TFs bind enhancers and promoters at the same time?
Give this one a try later!
DNA between the enhancers and promoters bends
Cis-regulatory elements
Give this one a try later!
DNA sequences on the same piece of DNA as a gene that regulates
transcription of the gene (ex: enhancers and promoters)
All of the DNA in your body straightened out and laid end to end would reach from
here to...
Give this one a try later!
