Things to look for when assessing blinding
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- Were the treatments sufficiently similar to prevent people from figuring
out who was receiving what?
- Did the authors say who was blinded? I.e., were specific groups named, or
was the description vague (e.g., 'double-blind')?
- If blinding was not possible or not done, was the primary outcome
objective?
Why should interpretation be done properly?
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, - To ensure that results are not exaggerated, to ensure that the reader is
aware if the current findings conflict with previous findings, and to ensure
that serious trial defects are not simply ignored
Things to look for when assessing sample size
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- Do the authors say they did a calculation?
- Do they mention any of the four variables needed for a sample size
calculation
(alpha, power, effect size, variance)?
- Were the analyzed groups (as shown in the flow chart) at least as large as
the calculated sample size, or was the trial underpowered?
Things to look for when assessing participant losses
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- Is there a flow chart? Does it show losses, with reasons?
- Has everyone been accounted for? (I.e., has an ITT analysis been
performed?)
- Are there too many losses?
Things to look for when assessing participants and generalizability
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- Were the treatments sufficiently similar to prevent people from figuring
out who was receiving what?
- Did the authors say who was blinded? I.e., were specific groups named, or
was the description vague (e.g., 'double-blind')?
- If blinding was not possible or not done, was the primary outcome
objective?
Why should interpretation be done properly?
Give this one a try later!
, - To ensure that results are not exaggerated, to ensure that the reader is
aware if the current findings conflict with previous findings, and to ensure
that serious trial defects are not simply ignored
Things to look for when assessing sample size
Give this one a try later!
- Do the authors say they did a calculation?
- Do they mention any of the four variables needed for a sample size
calculation
(alpha, power, effect size, variance)?
- Were the analyzed groups (as shown in the flow chart) at least as large as
the calculated sample size, or was the trial underpowered?
Things to look for when assessing participant losses
Give this one a try later!
- Is there a flow chart? Does it show losses, with reasons?
- Has everyone been accounted for? (I.e., has an ITT analysis been
performed?)
- Are there too many losses?
Things to look for when assessing participants and generalizability
Give this one a try later!
