Describe the chain of events that occur shortly following oligomerization of the BCR
upon antigen binding.
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Ag binding induces conformational change in Cμ4 domain>This causes
oligomerization of Ag-bound IgM molecules in the plane of the
membrane>The molecules move into lipid rafts of the membrane>This
allows association of BCR signaling molecules, triggering B-cell signaling
cascades
Name the chemokines that B cells follow as they become activated and migrate
through secondary lymphoid tissue.
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, CXCR5 receptor binds to CXCL13 expressed by FCDs in the B-cell follicles
(cortical region of the secondary lymphoid tissue).
Upon finding antigen CCR7 receptor binds to CCL19 and CCL21 secreted
by stromal cells in the T-cell zones and the B cell moves in the boundary
between the B-cell and T-cell zones.
Why is Listeria able to persist in hosts with healthy immune function?
Give this one a try later!
Pathogen found in soil and food; can cause serious illness,
stillbirth/miscarriage, and fatality
Fluorescent labeling shows Listeria move to the spleen through blood and
are ingested by DCs
DCs form stable interactions with CD8+ T cells
-IMAGE: Listeria (red) forms actin comets (green) to propel itself from the
cytoplasm of one cell to another, infecting the new cell
-CD8+ cells interacting with DCs are prime targets!
What is AID; what does it do; what does it convert cytosine into?
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Activation-induced cytidine deaminase
Produces opportunity for mutation by altering deoxycytidine bases
What cells are found in dark and light zones of germinal centers and in the "mantle
zone"?
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upon antigen binding.
Give this one a try later!
Ag binding induces conformational change in Cμ4 domain>This causes
oligomerization of Ag-bound IgM molecules in the plane of the
membrane>The molecules move into lipid rafts of the membrane>This
allows association of BCR signaling molecules, triggering B-cell signaling
cascades
Name the chemokines that B cells follow as they become activated and migrate
through secondary lymphoid tissue.
Give this one a try later!
, CXCR5 receptor binds to CXCL13 expressed by FCDs in the B-cell follicles
(cortical region of the secondary lymphoid tissue).
Upon finding antigen CCR7 receptor binds to CCL19 and CCL21 secreted
by stromal cells in the T-cell zones and the B cell moves in the boundary
between the B-cell and T-cell zones.
Why is Listeria able to persist in hosts with healthy immune function?
Give this one a try later!
Pathogen found in soil and food; can cause serious illness,
stillbirth/miscarriage, and fatality
Fluorescent labeling shows Listeria move to the spleen through blood and
are ingested by DCs
DCs form stable interactions with CD8+ T cells
-IMAGE: Listeria (red) forms actin comets (green) to propel itself from the
cytoplasm of one cell to another, infecting the new cell
-CD8+ cells interacting with DCs are prime targets!
What is AID; what does it do; what does it convert cytosine into?
Give this one a try later!
Activation-induced cytidine deaminase
Produces opportunity for mutation by altering deoxycytidine bases
What cells are found in dark and light zones of germinal centers and in the "mantle
zone"?
Give this one a try later!
