Combinatorial association of heavy and light chains
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when they combine it changes the antigen being bound
Epitope
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clonal selection
N region nucleotides
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up to 15 nucleotides at cut ends of V, D, J coding regions by
deoxynucleotidyl transferase
Ig diversity between species
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humans and mice undergo similar diversity processes in bone marrow
in birds, rabbits, sheep, cattle most of B cell development occurs in GALT
utilize one or a few rearrangements of germline VDJ genes
somatic hyper mutation or gene conversion is used to extensively diversify
the rearranged genes
Class (isotype) switching
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mature B cells produce membrane IgM and IgD
upon proper antigenic stimulation, B cells gain the ability to change the
heavy chain isotype
although all isotype switching events are not entirely understood, it is
known that cytokines and AID play a role
consists of switch sequences, switch recombinase, AID, and switch factors
T1D
Give this one a try later!
Give this one a try later!
when they combine it changes the antigen being bound
Epitope
Give this one a try later!
clonal selection
N region nucleotides
, Give this one a try later!
up to 15 nucleotides at cut ends of V, D, J coding regions by
deoxynucleotidyl transferase
Ig diversity between species
Give this one a try later!
humans and mice undergo similar diversity processes in bone marrow
in birds, rabbits, sheep, cattle most of B cell development occurs in GALT
utilize one or a few rearrangements of germline VDJ genes
somatic hyper mutation or gene conversion is used to extensively diversify
the rearranged genes
Class (isotype) switching
Give this one a try later!
mature B cells produce membrane IgM and IgD
upon proper antigenic stimulation, B cells gain the ability to change the
heavy chain isotype
although all isotype switching events are not entirely understood, it is
known that cytokines and AID play a role
consists of switch sequences, switch recombinase, AID, and switch factors
T1D
Give this one a try later!
