PCB4233 EXAM 2 FIB QUESTIONS WITH COMPLETE ANSWERS

1?




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, BLK, Fyn, Lyn




T_____ cells coordinate responses mostly to intracellular pathogens often found in
macrophages, they produce large quantity of IFNy


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Th1




____________ cells recognize processed antigens presented by interdigitating DC


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naive T




the activation of naive T or B cell upon binding of the TCR or BCR generates small
molecules called second messengers, an example of these second messengers is
__________.


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calcium OR IP3




during development of B cells, ______________ describes the restriction of expression of
the individual chains of the BCR [aka only one chromosome provide a productive

, rearrangement] so that each individual B cell produces an immunoglobulin of a single
antigen specificity


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allelic exclusion




The primary lymphoid organs where the B and T cells mature are _________ and _________.


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BM; Thymus




The 3 transcription factors up regulated in naive T cells upon activation are _______,
_______, and _______; they lead to the synthesis of the cytokine which is necessary for the
proliferation of the recently activated T cell


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NFAT; NFkB; AP-1




effector B cells secreting IgG relocate mostly to ____________, while effector B cells
secreting IgA relocate mainly to the mucosa.


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bone marrow