Study Guide Exam Questions and Answers
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Serotonin regulates - CORRECT ANSWERS Mood, emotion, feeding, and reproductive
behavior
This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to
increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors - CORRECT ANSWERS
SSRIs
First line therapy for MDD due to milder side effect profiles - CORRECT ANSWERS SSRIs
Six Common SSRIs - CORRECT ANSWERS citalopram, escitalopram, fluoxetine, fluvoxamine,
sertraline, paroxetine
Onset of therapeutic benefit from SSRIs - CORRECT ANSWERS 4-6 weeks
In addition to MDD, SSRIs also treat - CORRECT ANSWERS Chronic Anxiety, PTSD, OCD, and
eating disorders (bulimia)
Five Common side effects of SSRIs include - CORRECT ANSWERS Anxiety, insomnia, GI
distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years old - CORRECT ANSWERS
suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in combination with other serotonergic
drugs (SNRIs, TCAs, MAOIs, etc.) - CORRECT ANSWERS Serotonin Syndrome
,Excess accumulation of serotonin resulting in overstimulation of the nervous system - CORRECT
ANSWERS Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - CORRECT ANSWERS Flushing, hyperthermia,
agitation, muscle rigidity, seizure, coma, HYPERreflexia
The treatment for serotonin syndrome - CORRECT ANSWERS Cyproheptadine (5-HT2 receptor
antagonist)
Cyproheptadine treats serotonin syndrome by - CORRECT ANSWERS blocking 5-HT2 receptors
(serotonin antagonist)
When SSRIs or SNRIs are stopped abruptly, common symptoms of withdrawal include - CORRECT
ANSWERS Irritability, headaches, and insomnia
Medicine specific side effect of citalopram - CORRECT ANSWERS Prolonged QT interval
(normal=0.4.-0.44 seconds)
This SSRI is pregnancy category D due to associations with congenital heart defects - CORRECT
ANSWERS Paroxetine
All SSRIs but paroxetine (D) are pregnancy category - CORRECT ANSWERS C
Three SSRIs that are inhibitors of Cytochrome P450 enzymes - CORRECT ANSWERS fluoxetine,
fluvoxamine, and paroxetine
Five common SNRIs include - CORRECT ANSWERS duloxetine, venlafaxine, desvenlafaxine,
milnacipran, levomilnacipran
, This antidepressant class of medications works by binding to presynaptic SERT and NET to inhibit them
from reuptake of serotonin and norepinephrine to increase their levels in the synaptic cleft - CORRECT
ANSWERS SNRIs
In addition to MDD SNRIs treat - CORRECT ANSWERS Anxiety and neuropathic pain
(peripheral neuropathy)
Medication specific indications of duloxetine: - CORRECT ANSWERS urinary incontinence and
Fibromyalgia
Medication specific indications of venlafaxine: - CORRECT ANSWERS social anxiety, panic
disorders, PTSD, OCD, postmenopausal hot flashes
Six common side effects of SNRIs include: - CORRECT ANSWERS Insomnia, nausea, sexual
dysfunction, hypertension, sweating, headaches
Severe side effect of SNRIs in children/adolescents under age 25 years old: - CORRECT ANSWERS
suicidal ideation
Life threatening adverse effect of SNRIs, especially when used in combination with other serotonergic
drugs: - CORRECT ANSWERS Serotonin Syndrome
This SNRI is an inhibitor of Cytochrome P450 enzymes: - CORRECT ANSWERS venlafaxine
This SNRI is hepatotoxic: - CORRECT ANSWERS duloxetine
MAOIs increase the levels of: - CORRECT ANSWERS Serotonin, Norepinephrine, and
Dopamine