1|Page
AGACNP AACN BOARDS EXAM NEWEST 2025/ 2026 TEST
BANK| 2 VERSIONS (VERSION A & B) WITH COMPLETE 1800
REAL EXAM QUESTIONS AND CORRECT VERIFIED
ANSWERS/ ALREADY GRADED A+| AACN AGACNP BOARDS
EXAM PREP (BRAND NEW!!)
What ABG is associated with chronic bronchitis? Why? - ANSWER -
Hypercapnia, hypoxemia. Air is trapped in alveoli and overtime
chemoreceptors reset to accommodate high CO2 levels.
What CXR findings are associated with COPD? - ANSWER -
Hyperinflation - low, flattened diaphragm
Bulla, blebs
What is the outpatient management of COPD? - ANSWER - Postural
drainage
Smoking cessation
Inhaled ipratroprium bromide (Atrovent) or sympathomimetics -
anticholinergics - secretion management
58 yo. M presents to ED with PMH significant for COPD, home O2 2L
NC. Pt is coughing up purulent, thick, yellow mucous. What would you
do as the ACNP? - ANSWER - O2 NC 2-4 L min or 24-28% venti mask
Start antibiotics - 7-10days
Ampicillin or amoxicillin 500 mg QID PO for 7-10days
pg. 1
,2|Page
Doxycyline 100 mg BID
Bactrim DS 1 tablet BID
What is the most common clinical presentation of Tuberculosis? -
ANSWER - Pulmonary disease. TB is a systemic dx that is often
asymptomatic.
What are the classic signs and symptoms of TB? - ANSWER - Dry
cough progressing to productive with blood tinged sputum
Night sweats
Fever, chills
Weight loss
Identify the definitive diagnosis of TB. - ANSWER - Culture of M.
tuberculosis x 3
PPD + - send for CXR
CXR - Small, homogenous infiltrates in upper lobes
What are the drugs used in initial TB treatment? - ANSWER - Isoniazid
300 mg
Rifampin 600 mg
Pyrazinamide 1.5-2.0 gm
Ethambutol 15 mg/kg
pg. 2
,3|Page
Explain the duration of TB therapy - ANSWER - Isoniazid 300 mg,
Rifampin 600 mg, pyrazinamide 1.5-2.0 gm and ethambutol 15 mg/kg
daily x 2 months THEN
Isoniazid 300 mg and Rifampin 600 mg daily x 4 months
What is duration of therapy for a patient with HIV diagnosed with TB? -
ANSWER - NINE months
What is the monitoring protocol for patient newly diagnosed with
pulmonary TB? - ANSWER - Weekly sputum smears and cultures for
SIX weeks then MONTHLY after negative cultures
What labs should be evaluated at baseline when initiating TB therapy? -
ANSWER - Liver function tests
CBC
serum Creatinine
What is the risk with ethambutol? - ANSWER - Changes in visual acuity
Red-green color blind
For those with a positive PPD test, what drug is indicated and for how
long? - ANSWER - INH x 6 months
High risk - 5 mm induration
Moderate risk - 10 mm induration
pg. 3
, 4|Page
Low risk - 15 mm induration
Define PNA. - ANSWER - Inflammation of the LOWER respiratory
tract
What microorganism is most responsible for community acquired
pneumonia (CAP)? - ANSWER - Strep. pneumoniae - gram +
What is the gold standard in diagnosing PNA? - ANSWER - CXR -
infiltrates
Blood cultures x 3
What is the inpatient ICU management of a patient dx with PNA? -
ANSWER - Beta lactam - ceftriaxone (Rocephin)
PLUS
either azithromycin (Zithromax) or fluroquinolone
What is the inpatient ICU management of a patient with Psuedomonas
PNA? - ANSWER - Antipneumococcal, antipseudomonal beta lactam
- Piperacillin-tazobactam (Zosyn)
- cefepime (Maxipime)
- Meropenem (Merrem)
pg. 4
AGACNP AACN BOARDS EXAM NEWEST 2025/ 2026 TEST
BANK| 2 VERSIONS (VERSION A & B) WITH COMPLETE 1800
REAL EXAM QUESTIONS AND CORRECT VERIFIED
ANSWERS/ ALREADY GRADED A+| AACN AGACNP BOARDS
EXAM PREP (BRAND NEW!!)
What ABG is associated with chronic bronchitis? Why? - ANSWER -
Hypercapnia, hypoxemia. Air is trapped in alveoli and overtime
chemoreceptors reset to accommodate high CO2 levels.
What CXR findings are associated with COPD? - ANSWER -
Hyperinflation - low, flattened diaphragm
Bulla, blebs
What is the outpatient management of COPD? - ANSWER - Postural
drainage
Smoking cessation
Inhaled ipratroprium bromide (Atrovent) or sympathomimetics -
anticholinergics - secretion management
58 yo. M presents to ED with PMH significant for COPD, home O2 2L
NC. Pt is coughing up purulent, thick, yellow mucous. What would you
do as the ACNP? - ANSWER - O2 NC 2-4 L min or 24-28% venti mask
Start antibiotics - 7-10days
Ampicillin or amoxicillin 500 mg QID PO for 7-10days
pg. 1
,2|Page
Doxycyline 100 mg BID
Bactrim DS 1 tablet BID
What is the most common clinical presentation of Tuberculosis? -
ANSWER - Pulmonary disease. TB is a systemic dx that is often
asymptomatic.
What are the classic signs and symptoms of TB? - ANSWER - Dry
cough progressing to productive with blood tinged sputum
Night sweats
Fever, chills
Weight loss
Identify the definitive diagnosis of TB. - ANSWER - Culture of M.
tuberculosis x 3
PPD + - send for CXR
CXR - Small, homogenous infiltrates in upper lobes
What are the drugs used in initial TB treatment? - ANSWER - Isoniazid
300 mg
Rifampin 600 mg
Pyrazinamide 1.5-2.0 gm
Ethambutol 15 mg/kg
pg. 2
,3|Page
Explain the duration of TB therapy - ANSWER - Isoniazid 300 mg,
Rifampin 600 mg, pyrazinamide 1.5-2.0 gm and ethambutol 15 mg/kg
daily x 2 months THEN
Isoniazid 300 mg and Rifampin 600 mg daily x 4 months
What is duration of therapy for a patient with HIV diagnosed with TB? -
ANSWER - NINE months
What is the monitoring protocol for patient newly diagnosed with
pulmonary TB? - ANSWER - Weekly sputum smears and cultures for
SIX weeks then MONTHLY after negative cultures
What labs should be evaluated at baseline when initiating TB therapy? -
ANSWER - Liver function tests
CBC
serum Creatinine
What is the risk with ethambutol? - ANSWER - Changes in visual acuity
Red-green color blind
For those with a positive PPD test, what drug is indicated and for how
long? - ANSWER - INH x 6 months
High risk - 5 mm induration
Moderate risk - 10 mm induration
pg. 3
, 4|Page
Low risk - 15 mm induration
Define PNA. - ANSWER - Inflammation of the LOWER respiratory
tract
What microorganism is most responsible for community acquired
pneumonia (CAP)? - ANSWER - Strep. pneumoniae - gram +
What is the gold standard in diagnosing PNA? - ANSWER - CXR -
infiltrates
Blood cultures x 3
What is the inpatient ICU management of a patient dx with PNA? -
ANSWER - Beta lactam - ceftriaxone (Rocephin)
PLUS
either azithromycin (Zithromax) or fluroquinolone
What is the inpatient ICU management of a patient with Psuedomonas
PNA? - ANSWER - Antipneumococcal, antipseudomonal beta lactam
- Piperacillin-tazobactam (Zosyn)
- cefepime (Maxipime)
- Meropenem (Merrem)
pg. 4
