Polycystic Ovarian Syndrome
Definition A heterogeneous group of disorders that causes
metabolic and reproductiveproblems in women
Characteristics include Multiple ovarian cysts
Oligomenorrhea
Hyperandrogenism
Insul resistance
infertility
Aetiology Androgen excess
AA LH
several theories
Theca cell
Pituitary cause of t
PCOS
Ovarian cause of ppandrogengthAndrogens
Lto
feedback
PLH Thecacells
Arandtrogens PCOS
Metabolicsyndrome of insuline resistance
Hyperinsouriaemia DIABETES WHO group l I
b
Wsteroidhormone
an ovulation
of MPO
binding
owbujin.BGaqdpqq dysfunction
99Androgens PCOS
central
Signs and obesity
symptoms Menstrual abnormalities 851
I
Oligomenorrhea 70 Amenorrhea 15
infrequent 76 months of no menstrual
menstrual periods
35 between
period
days
Hirsutism Excessive growth of dark or course
2 hair in a male like pattern face
651 chest back
and insulin resistance
Obesity
Acne 30 g't
Pathophysiology Higher Ltt than Androstenedione
FSH m produces more
LH theca cells androgens than
FSH Granulosacells FSH can deal with
Aromataseenzyme
I
0estradiolLEZ
Definition A heterogeneous group of disorders that causes
metabolic and reproductiveproblems in women
Characteristics include Multiple ovarian cysts
Oligomenorrhea
Hyperandrogenism
Insul resistance
infertility
Aetiology Androgen excess
AA LH
several theories
Theca cell
Pituitary cause of t
PCOS
Ovarian cause of ppandrogengthAndrogens
Lto
feedback
PLH Thecacells
Arandtrogens PCOS
Metabolicsyndrome of insuline resistance
Hyperinsouriaemia DIABETES WHO group l I
b
Wsteroidhormone
an ovulation
of MPO
binding
owbujin.BGaqdpqq dysfunction
99Androgens PCOS
central
Signs and obesity
symptoms Menstrual abnormalities 851
I
Oligomenorrhea 70 Amenorrhea 15
infrequent 76 months of no menstrual
menstrual periods
35 between
period
days
Hirsutism Excessive growth of dark or course
2 hair in a male like pattern face
651 chest back
and insulin resistance
Obesity
Acne 30 g't
Pathophysiology Higher Ltt than Androstenedione
FSH m produces more
LH theca cells androgens than
FSH Granulosacells FSH can deal with
Aromataseenzyme
I
0estradiolLEZ
