ONS Chemotherapy Immunotherapy
Certificate Exam: Questions With 100%
Complete Solutions 2025|2026 Latest
Update
LHRH antagonists MOA - correct answer-Directly inhibits pituitary from
releasing LH and FSH
*No tumor flare
Most common type of breast cancer - correct answer-Hormone
receptor (HR)-positive breast cancer
Aromatase inhibitors MOA - correct answer-Block the enzyme
aromatase, which turns the hormone androgen into small amounts of
estrogen in the body
**Less estrogen is available to stimulate growth of HR-positive breast
cancer cells
,2 types of aromatase inhibitors - correct answer-1. Steroidal
(irreversible)
2. Nonsteroidal (reversible)
3 aromatase inhibitors - correct answer-Anastrozole
Letrozole
Exemestane
Common side effects of aromatase inhibitors (AI): - correct answer-
Fatigue
N/V*
Weakness
HA*
Insomnia
Dizziness
Hot flashes*
Weight gain*
Higher cholesterol
,Increased sweating*
Bone/joint pain*
Selective ER downregulators (SERDs) MOA - correct answer-Binding to
and degrading ER
Common SERD - correct answer-Fulvestrant
Selective ER modulators (SERMs) MOA - correct answer-Blocking and
downregulating ERs
*Can function as ER agonists, antagonists, or mixed agonist-antagonists
*Can activate or block estrogen
Common SERMs - correct answer-Tamoxifen
Raloxifine
Bazedoxifine
, Antiandrogens MOA - correct answer-Keeps androgens from binding to
androgen receptors found in prostate cancer cells (and in some other
tissue cells)
Androgen synthesis inhibitors MOA - correct answer-Stop the adrenal
glands from producing androgens
Common androgen synthesis inhibitors - correct answer-Ketoconazole
Aminoglutethimide
Abiraterone acetate
CYP17 inhibitors MOA - correct answer-Inhibit the key enzyme that
catalyzes biosynthesis of androgens from all sources
Common CYP17 inhibitors - correct answer-Abiraterone
Orteronel
Certificate Exam: Questions With 100%
Complete Solutions 2025|2026 Latest
Update
LHRH antagonists MOA - correct answer-Directly inhibits pituitary from
releasing LH and FSH
*No tumor flare
Most common type of breast cancer - correct answer-Hormone
receptor (HR)-positive breast cancer
Aromatase inhibitors MOA - correct answer-Block the enzyme
aromatase, which turns the hormone androgen into small amounts of
estrogen in the body
**Less estrogen is available to stimulate growth of HR-positive breast
cancer cells
,2 types of aromatase inhibitors - correct answer-1. Steroidal
(irreversible)
2. Nonsteroidal (reversible)
3 aromatase inhibitors - correct answer-Anastrozole
Letrozole
Exemestane
Common side effects of aromatase inhibitors (AI): - correct answer-
Fatigue
N/V*
Weakness
HA*
Insomnia
Dizziness
Hot flashes*
Weight gain*
Higher cholesterol
,Increased sweating*
Bone/joint pain*
Selective ER downregulators (SERDs) MOA - correct answer-Binding to
and degrading ER
Common SERD - correct answer-Fulvestrant
Selective ER modulators (SERMs) MOA - correct answer-Blocking and
downregulating ERs
*Can function as ER agonists, antagonists, or mixed agonist-antagonists
*Can activate or block estrogen
Common SERMs - correct answer-Tamoxifen
Raloxifine
Bazedoxifine
, Antiandrogens MOA - correct answer-Keeps androgens from binding to
androgen receptors found in prostate cancer cells (and in some other
tissue cells)
Androgen synthesis inhibitors MOA - correct answer-Stop the adrenal
glands from producing androgens
Common androgen synthesis inhibitors - correct answer-Ketoconazole
Aminoglutethimide
Abiraterone acetate
CYP17 inhibitors MOA - correct answer-Inhibit the key enzyme that
catalyzes biosynthesis of androgens from all sources
Common CYP17 inhibitors - correct answer-Abiraterone
Orteronel
