NR 546 Final Exam (Latest Update 2025 /
2026) Advanced Pharmacology
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner Questions
and 100% correct Verified Answers [GRADE
A] – Chamberlain
During a 4 week follow up appointment, Rashida, who is prescribed Sertraline 25mg
qAM reports slight improvement in depression symptoms and tolerating medication
well. Which of the following should the PMHNP do?
A. Increase Setraline dose
B. Switch to an SNRI
C. Switch to a different SSRI
D. Add Trazodone qHS for sleep. - correct answer A. Increase Setraline dose
Which medication should be avoided for the 66 year patient diagnosed with major
depressive disorder and anxiety with a reported fall 3 months ago?
A. Citalopram
B. Setraline
C. Paroxetine
D. Aripiprazole - correct answer C. Paroxetine
A patient reports upset stomach and diarrhea 3 days after taking new prescription of
sertraline. Which of the following is the most appropriate response from the PMHNP?
A. "Start doubling the dose of sertraline and your symptoms will begin to ease up".
B. "Most side effects subside after 4-5 days. Your body is getting adjusted to the
increased serotonin levels".
C. "Stop taking it immediately and go to the local emergency department".
D. "You must take Sertraline with food, otherwise you will continue to experience GI
symptoms". - correct answer B. "Most side effects subside after 4-5 days. Your body is
getting adjusted to the increased serotonin levels".
During a 2 week follow up appointment, the patient reports no improvement in
depressive symptoms with escitalopram. Which of the following statement made by
the PMHNP is correct?
, NR 546 Final Exam (Latest Update 2025 /
2026) Advanced Pharmacology
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner Questions
and 100% correct Verified Answers [GRADE
A] – Chamberlain
A. "Let's discontinue escitalopram and start you on something stronger".
B. "It can take up to 6 weeks before you notice improvements of depressive
symptoms".
C. "I am going to prescibe Trazodone. Take it at night to help you sleep".
D. "Start taking two pills at a time". - correct answer B. "It can take up to 6 weeks
before you notice improvements of depressive symptoms".
Duloxetine effects which two neurotransmitters?
A. serotonin and norepinephrine
B. serotonin and dopamine
C. norepinephrine and GABA
D. glutamate and acetylcholine - correct answer A. serotonin and norepinephrine
Awura, a 70 year old patient diagnosed with major depressive disorder reports a
recent 40 pound weight loss within the last 3 months. Which medication should the
PMHNP consider adding to her medication regimen?
A. quetiapine
B. mirtazpine
C. valproic acid
D. paroxetine - correct answer B. mirtazpine
Which of the following symptoms is NOT an adverse effect associated with the acute
use of opioids?
A. Sedation
B. Respiratory depression
C. Immunosuppression
D. Itching - correct answer C. Immunosuppression
, NR 546 Final Exam (Latest Update 2025 /
2026) Advanced Pharmacology
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner Questions
and 100% correct Verified Answers [GRADE
A] – Chamberlain
When dosing citalopram for Lynee, a 72 year old patient, the PMHNP understands to
dose at 1/2 dose due to the increased risk of
A. delirium
B. polypharmacy
C. falls
D. QTc prolongation - correct answer D. QTc prolongation
Which of the following medication class is approved for first line treatment for OCD?
A. Atypical antipsychotics
B. Benzodiazepines
C. MAOI
D. SSRI - correct answer D. SSRI
Which SSRI has a mild antihistamine effect?
A. Paroxetine
B. Fluoxetine
C. Citalopram
D. Sertraline - correct answer C. Citalopram
Which medication should the PMHNP prescribe for a patient diagnosed with major
depressive disorder but takes multiple medications for other chronic conditions?
A. Sertraline
B. Escitalopram
C. Buspirone
D. Clonazepam - correct answer B. Escitalopram
The patient reports suffering from insomnia and anxiety. Which SSRI should be
prescribed?
2026) Advanced Pharmacology
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner Questions
and 100% correct Verified Answers [GRADE
A] – Chamberlain
During a 4 week follow up appointment, Rashida, who is prescribed Sertraline 25mg
qAM reports slight improvement in depression symptoms and tolerating medication
well. Which of the following should the PMHNP do?
A. Increase Setraline dose
B. Switch to an SNRI
C. Switch to a different SSRI
D. Add Trazodone qHS for sleep. - correct answer A. Increase Setraline dose
Which medication should be avoided for the 66 year patient diagnosed with major
depressive disorder and anxiety with a reported fall 3 months ago?
A. Citalopram
B. Setraline
C. Paroxetine
D. Aripiprazole - correct answer C. Paroxetine
A patient reports upset stomach and diarrhea 3 days after taking new prescription of
sertraline. Which of the following is the most appropriate response from the PMHNP?
A. "Start doubling the dose of sertraline and your symptoms will begin to ease up".
B. "Most side effects subside after 4-5 days. Your body is getting adjusted to the
increased serotonin levels".
C. "Stop taking it immediately and go to the local emergency department".
D. "You must take Sertraline with food, otherwise you will continue to experience GI
symptoms". - correct answer B. "Most side effects subside after 4-5 days. Your body is
getting adjusted to the increased serotonin levels".
During a 2 week follow up appointment, the patient reports no improvement in
depressive symptoms with escitalopram. Which of the following statement made by
the PMHNP is correct?
, NR 546 Final Exam (Latest Update 2025 /
2026) Advanced Pharmacology
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner Questions
and 100% correct Verified Answers [GRADE
A] – Chamberlain
A. "Let's discontinue escitalopram and start you on something stronger".
B. "It can take up to 6 weeks before you notice improvements of depressive
symptoms".
C. "I am going to prescibe Trazodone. Take it at night to help you sleep".
D. "Start taking two pills at a time". - correct answer B. "It can take up to 6 weeks
before you notice improvements of depressive symptoms".
Duloxetine effects which two neurotransmitters?
A. serotonin and norepinephrine
B. serotonin and dopamine
C. norepinephrine and GABA
D. glutamate and acetylcholine - correct answer A. serotonin and norepinephrine
Awura, a 70 year old patient diagnosed with major depressive disorder reports a
recent 40 pound weight loss within the last 3 months. Which medication should the
PMHNP consider adding to her medication regimen?
A. quetiapine
B. mirtazpine
C. valproic acid
D. paroxetine - correct answer B. mirtazpine
Which of the following symptoms is NOT an adverse effect associated with the acute
use of opioids?
A. Sedation
B. Respiratory depression
C. Immunosuppression
D. Itching - correct answer C. Immunosuppression
, NR 546 Final Exam (Latest Update 2025 /
2026) Advanced Pharmacology
Psychopharmacology for the Psychiatric-
Mental Health Nurse Practitioner Questions
and 100% correct Verified Answers [GRADE
A] – Chamberlain
When dosing citalopram for Lynee, a 72 year old patient, the PMHNP understands to
dose at 1/2 dose due to the increased risk of
A. delirium
B. polypharmacy
C. falls
D. QTc prolongation - correct answer D. QTc prolongation
Which of the following medication class is approved for first line treatment for OCD?
A. Atypical antipsychotics
B. Benzodiazepines
C. MAOI
D. SSRI - correct answer D. SSRI
Which SSRI has a mild antihistamine effect?
A. Paroxetine
B. Fluoxetine
C. Citalopram
D. Sertraline - correct answer C. Citalopram
Which medication should the PMHNP prescribe for a patient diagnosed with major
depressive disorder but takes multiple medications for other chronic conditions?
A. Sertraline
B. Escitalopram
C. Buspirone
D. Clonazepam - correct answer B. Escitalopram
The patient reports suffering from insomnia and anxiety. Which SSRI should be
prescribed?
