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CMCB EXAM 2 QUESTIONS WITH COMPLETE ANSWERS

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CMCB EXAM 2 QUESTIONS WITH COMPLETE ANSWERS

Institution
CMCB
Course
CMCB

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Calcium ion could come from G protein-coupled receptor/endoplasmic reticulum or
direct action of voltage-gated calcium channels. This calcium ions bind to _____, and
then calcium/calmodulin activates _____.


Give this one a try later!


calmodulin/MLCK.

Lecture 14, Slide 16




Intraflagellar transport (IFT) within primary cilia is mediated by _____ and cytoplasmic
_____.


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kinesin-2/dynein-2

, Lecture 15, Slide 27




The highly dynamic spindle microtubules probe the cytoplasm and begin "capturing"
chromosomes by connecting to the _____ that have developed on the centromeres. A
tug-of-war then ensues as the chromosomes jockey back and forth between the two
poles.


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kinetochores
Lecture 16, Slide 14




Microtubules are generally nucleated from a specific intracellular location known as a
microtubule-organization center (MTOC). Animal cells have a single, well-defined
MTOC called the _____, located near the nucleus.It consists two barrel-shaped _____ that
are embedded in an amorphous matrix of fibrous proteins (pericentriolar material)
where the ____-___ ring complexes are attached.


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centrosome/centrioles/gamma-tubulin

Lecture 15, Slide 9




There are 4 classes of intermediate filaments we discussed. Which one(s) is/are
cytoplasmic and which one(s) is/are nuclear?


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, cytoplasmic: keratin filaments, vimentin, neurofilaments
nuclear: lamins


Lecture 14, Slide 18




All IF proteins have a very highly conserved central rod ____. Variations in the head (____
terminus) and tail (_____ terminus) regions of the proteins differentiate the subfamilies of
IFproteins.


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domain/amino/carboxy

Lecture 14, Slide 19




_____ are rapidly assembled and dissembled during cell division and form a stable array
structure in ____ cells.


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Microtubules/interphase


Lecture 15, Slide 2




True or false? EB-1 moves toward plus ends of MTs.


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, False, EB-1 does not move toward plus ends, but recognizes a structural
feature of the growing positive end. EB-1 mediates the interaction with
other proteins

Lecture 15, Slide 15




Myosin II is used in a lot of situations. Migrating cells use actin filaments. These actin
filaments are called ____ ____. Some of these are associated with myosin II.


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stress fibers

Lecture 14, Slide 4




The microtubule is stabilized by the ____ interaction between monomer of the same
type (alpha-alpha and beta- beta). A slight stagger (0.9 nm) in lateral contacts
produce a helical structure, which accommodates 13 _____. This microtubule
organization gives intrinsic ____ (plus end and minus end), and make the addition and
loss of subunits almost exclusively occur at the microtubule ends.


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lateral/protofilaments/polarity

Lecture 15, Slide 3




Myosin II is a component of the contractile ring during _____, the final step of mitosis.


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Institution
CMCB
Course
CMCB

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