NSG552 PSYCHOPHARMACOLOGY EXAM 1
ACTUAL 2025/2026 QUESTIONS AND 100%
CORRECT ANSWERS
Save
Terms in this set (215)
General principles of Safety, Tolerability, Efficacy, Practicality, Treatment
psychopharmacological treatment accessibility, Treatment compliance
Pharmacokinetics How the drug moves in the body. (ex. Where is it
absorbed? How and where is it metabolized?
Where is it excreted?)
Pharmacodynamics What the drug does to the body. (consider
mechanism of action)
First-generation antipsychotics Referred to as Typical Antipsychotics. Most have
strong bond with D2 receptors only, cause EPS
symptoms faster due to prolonged receptor
dissociation, have more dangerous side effect
profiles, have been around longer, more effective
at treating positive symptoms, less expensive. (Ex.
Haloperidol, Chlorpromazine, Thioridazine,
Fluphenazine)
, Second-generation antipsychotics Referred to as Atypical Antipsychotics. Most have a
weak bond with D2 receptors and block serotonin
receptors leading to anti-depressive and anxiolytic
effects. They cause less EPS due to rapid receptor
disassociation which leads to rapid dopamine
neurotransmission. Have less dangerous side effect
profiles but can cause metabolic syndromes, have
been around shorter time, more expensive, more
effective at treating negative symptoms but can
treat positive symptoms as well, long-acting
injections available for several of these. (Ex.
Risperidone, Clozapine, Quetiapine, Aripiprazole,
Ziprasidone)
Extra Pyramidal Symptoms (EPS) Side effects caused by certain antipsychotic
medications, which include: involuntary or
uncontrollable movements, tremors, muscle
contractions.
Tardive dyskinesia A neurological disorder characterized by
involuntary movement of the face and jaw.
Upregulation Occurs through chronic use of antagonists which
causes an increase in the number of receptors,
externalization of receptors, and increased
sensitivity of the receptors. Prolonged use of
antagonist -> Up-regulation of receptors -> Sudden
withdrawal of antagonist -> increased number of
receptors and increased sensitivity of receptors.
*YOU MUST GRADUALLY TAPER A DRUG TO
AVOID BINDING TO ALL NEW RECEPTORS FROM
UPREGULATION.
ACTUAL 2025/2026 QUESTIONS AND 100%
CORRECT ANSWERS
Save
Terms in this set (215)
General principles of Safety, Tolerability, Efficacy, Practicality, Treatment
psychopharmacological treatment accessibility, Treatment compliance
Pharmacokinetics How the drug moves in the body. (ex. Where is it
absorbed? How and where is it metabolized?
Where is it excreted?)
Pharmacodynamics What the drug does to the body. (consider
mechanism of action)
First-generation antipsychotics Referred to as Typical Antipsychotics. Most have
strong bond with D2 receptors only, cause EPS
symptoms faster due to prolonged receptor
dissociation, have more dangerous side effect
profiles, have been around longer, more effective
at treating positive symptoms, less expensive. (Ex.
Haloperidol, Chlorpromazine, Thioridazine,
Fluphenazine)
, Second-generation antipsychotics Referred to as Atypical Antipsychotics. Most have a
weak bond with D2 receptors and block serotonin
receptors leading to anti-depressive and anxiolytic
effects. They cause less EPS due to rapid receptor
disassociation which leads to rapid dopamine
neurotransmission. Have less dangerous side effect
profiles but can cause metabolic syndromes, have
been around shorter time, more expensive, more
effective at treating negative symptoms but can
treat positive symptoms as well, long-acting
injections available for several of these. (Ex.
Risperidone, Clozapine, Quetiapine, Aripiprazole,
Ziprasidone)
Extra Pyramidal Symptoms (EPS) Side effects caused by certain antipsychotic
medications, which include: involuntary or
uncontrollable movements, tremors, muscle
contractions.
Tardive dyskinesia A neurological disorder characterized by
involuntary movement of the face and jaw.
Upregulation Occurs through chronic use of antagonists which
causes an increase in the number of receptors,
externalization of receptors, and increased
sensitivity of the receptors. Prolonged use of
antagonist -> Up-regulation of receptors -> Sudden
withdrawal of antagonist -> increased number of
receptors and increased sensitivity of receptors.
*YOU MUST GRADUALLY TAPER A DRUG TO
AVOID BINDING TO ALL NEW RECEPTORS FROM
UPREGULATION.
