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Drug of choice when history of anaphylaxis or some other severe allergic reaction
to penicillins - CORRECT ANSWER-Avoid cephalosporin;
Vancomycin, erythromycin, and clindamycin are effective and safe alternatives for
patients with penicillin allergy.
Common drug used to treat bacterial infections in children. - CORRECT
ANSWER-Penicillins
First line treatment for infection following animal or human bites - CORRECT
ANSWER-Amoxicillin/clavulanate (Augmentin)
Medication common for streptococcal pharyngitis - CORRECT ANSWER-
Penicillin
,Penicillin Risk in Pregnancy - CORRECT ANSWER-evidence suggests there is no
second or third trimester fetal risk
Penicillin Risk in Infants - CORRECT ANSWER-Used safely in infants with
bacterial infections, including syphilis, meningitis, and group A streptococcus.
Amoxicillin - CORRECT ANSWER-Safe use during breastfeeding
Penicillin Use in Older Adults - CORRECT ANSWER-Doses should be adjusted in
older adults with renal dysfunction.
β-lactam antibiotic MOA - CORRECT ANSWER-All antibiotics in class share the
same mechanism of action: disruption of the bacterial cell wall.
Inhibition of cell wall synthesis
Empiric Therapy - CORRECT ANSWER-start treatment without cultures or prior
to receiving the results of a culture
,immediate empiric antibiotics - CORRECT ANSWER-Critically ill patients receive
(Fill in the Answer) after the first set of cultures obtained; do not wait for results.
Bactericidal antibiotics - CORRECT ANSWER-Directly kill bacteria: Agents
include aminoglycosides, beta-lactams, fluoroquinolones, metronidazole, most
antimycobacterial agents, streptogramins, and vancomycin.
preferred for immunocompromised patients such as those with diabetes, HIV, or
cancer and for those who have overwhelming infections
Bacteriostatic agents - CORRECT ANSWER-inhibit bacterial proliferation while
the host's immune system does the killing. Agents include clindamycin,
macrolides, sulfonamides, and tetracyclines
β-lactam Antibiotics - CORRECT ANSWER-Penicillins, Cephalosporins,
Carbapenems, Monobactams
Penicillins MOA - CORRECT ANSWER-Weaken bacterial cell wall by two
actions:
(1) inhibition of transpeptidases
(2) disinhibition (activation) of autolysins.
, PBPs (Penicillin Binding Proteins) - CORRECT ANSWER-Transpeptidases,
Autolysins, and other bacterial enzymes are collectively named as because
antibiotic class must bind to them to produce antibacterial effects.
gram-positive bacteria - CORRECT ANSWER-two layers: the cytoplasmic
membrane and a relatively thick cell wall; penicillins are generally very active
against these organisms.
gram-negative bacteria - CORRECT ANSWER-three layers: the cytoplasmic
membrane, a relatively thin cell wall, and an additional outer membrane; only
certain penicillins (e.g., ampicillin) are able to cross and reach penicillin binding
proteins (PBPs)
Four Major Groups of Penicillins - CORRECT ANSWER-(1) narrow-spectrum
penicillins that are penicillinase sensitive
(2) narrow-spectrum penicillins that are penicillinase resistant (antistaphylococcal
penicillins)
(3) broad-spectrum penicillins (aminopenicillins)