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BIO331 Final Exam – 110 Questions | Visual Pathways, Agnosia, Cortical Processing & Genetics

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This document is a comprehensive final exam preparation resource for BIO331, containing approximately 110 detailed, exam-oriented questions with direct answers that integrate material from Chapters 15, 1, and 14, as well as agnosia and cortical pathway readings. It is designed to support full-course revision by combining molecular genetics, sensory neuroscience, visual processing, and higher-order cortical function into a single, structured study guide suitable for final examinations. The genetics section provides a clear overview of human genome organization, gene identification strategies, homologous recombination, Mendelian versus complex inheritance patterns, linkage mapping, and applications to neurological diseases such as Huntington’s, Parkinson’s, Alzheimer’s, schizophrenia, and lipid storage disorders. These topics are explained with emphasis on experimental approaches, disease mapping, penetrance, and genotype–phenotype relationships commonly tested in upper-level biology and neuroscience courses. A major portion of the document focuses on visual system organization and cortical processing. It thoroughly explains retinal circuitry, phototransduction, rod and cone function, ON and OFF bipolar pathways, lateral inhibition, receptive fields, and the roles of horizontal, amacrine, and ganglion cells. Higher-level visual processing is covered in depth, including retinotopic organization, lateral geniculate nucleus layers, primary and extrastriate visual cortex (V1–V4), magnocellular, parvocellular, and koniocellular pathways, and dorsal (“where/how”) versus ventral (“what”) processing streams. The document also includes detailed lesion analyses, visual field defects, and clinical case-based diagnoses, making it particularly valuable for applied exam questions. In addition, the resource addresses perceptual and cognitive disorders such as visual agnosia, prosopagnosia, achromatopsia, simultanagnosia, neglect syndromes, akinetopsia, synesthesia, and phantom limb pain, linking neural damage to functional outcomes. This document is well suited for undergraduate students enrolled in courses such as Neurobiology, Neuroscience, Human Physiology, Sensory Systems, Cognitive Neuroscience, Biomedical Sciences, Biology, or pre-med and pre-health programs. It is especially useful for students preparing for cumulative finals, comprehensive reviews, or concept-heavy exams that require both mechanistic understanding and clinical interpretation. Keywords: visual pathways, cortical processing, visual agnosia, dorsal stream, ventral stream, visual cortex, retinal circuitry, phototransduction, ON OFF pathways, lateral geniculate nucleus, magnocellular pathway, parvocellular pathway, koniocellular pathway, visual field defects, sensory perception, neurogenetics, linkage mapping, Mendelian inheritance, neurological disorders, BIO331 final exam

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BIO331
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Voorbeeld van de inhoud

BIO331 FINAL CH15,1,14, agnosia
readings (cortical pathways, blindness,
sensory, review on NT release & Nernst
AP) 2025 Expert Verified | Ace the Test



Human genome: - 🧠ANSWER ✔✔→ 20,000genes


→ 10kB (23 chomos)


4 gene identification: - 🧠ANSWER ✔✔→ functional cloning=know prior

function of gene, purify, clone

→ candidate gene=identify common potential gene of all affected

patients(based on 1'pathology)

,→ positional cloning=identify gene w/o prior knowledge of fx; solely

mapping

→ positional candidate=identify EST/cDNA, compare it's location within

diseased locus map


Homologous Recombination: - 🧠ANSWER ✔✔→ 2 homo chromo pair

crossover (recombinations) btn sister chromatids

→ homo chromo segregate

→ duplicate chromo segregation yields cells containing only 1 copy of dz

chromo


Patterns of Mendelian inheritance: - 🧠ANSWER ✔✔→ autosomal

dominant-phenotype= 1 mutant gene copy to work

→ autosomal recessive phentotype=2 mutant gene copies to work

→ X linked=males at higher risk coz they only have 1 X(no second

chances)


Genetic (linkage) mapping: - 🧠ANSWER ✔✔→ procedure which trait is

located on genome based on segregation patterns

, → frequency of recombination events depend on length of segments,

nucleotide sequence, genomic location, gender dependent

→ consequence of recombination=diff offspring receive equal but not

identical genes from each parent

→ Linkage analysis=data mass collected till linake is detected/refuked.


Applications of linkage map: - 🧠ANSWER ✔✔→establish genetic basis of

traits

→ predict risk for disease

→ localize hereditary disorders to specific regions of the genome

→ clone genes by positional cloning

→ study gene conservation across species and chromosomal evolution


Factors affecting linkage mapping of a disease: - 🧠ANSWER ✔✔→

penetrance probability that carrier will have phenotype

→ frequency of the disease gene in population (Mendelian <0.1%)

→ age of onset variability




*most human dz are complex, not Mendelian(linkage)

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