Oncology - Naplex Exam 2025–2026 Accurate
Real Exam Questions and Verified Correct
Answers
Which of the following can be given intrathecally if they are preservative-free? (select all
that apply)
A) Cytarabine
B) Methotrexate
C) Vincristine
D) Hydrocortisone
E) Thiotepa
A) Cytarabine
B) Methotrexate
D) Hydrocortisone
E) Thiotepa
What are the warnings and signs of Melanoma skin cancer?
"ABCDE"
-A: Asymmetry; when bisected, the 2 sides are not identical
-B: Border; Uneven edges, pigment fading off
-C: Color; Mixtures of brown, tan, black, & red
-D: Diameter; >/= 6 mm
-E: Evolving; New lesion or lesion changing in size, shape or color
Which class of drugs is considered first-line adjuvant treatment for premenopausal
females with hormone-sensitive cancer?
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,Selective Estrogen Receptor Modulator (SERM)
Which class of drugs is not useful as monotherapy for breast cancer in premenopausal
females?
Aromatase Inhibitors (AIs)
Which monoclonal antibody binds to the HER2 receptor in breast cancer to prevent
dimerization?
Trastuzumab
What is the brand name of Trastuzumab?
Herceptin
What are the SERMs used for breast cancer?
1) Tamoxifen
2) Raloxifene
Which of the following is a prodrug converted via CYP2D6?
Tamoxifen
What drug is preferred to counter the hot flashes/night sweats caused by Tamoxifen?
Venlafaxine
Which of the following is used for postmenopausal breast cancer prevention and
osteoporosis prevention/treatment?
Raloxifene
What are the boxed warnings of SERMs?
Increased risk of uterine or endometrial cancer and increased risk of thromboembolic
events
What are the side effects of SERMs?
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, Hot flashes/night sweats, vaginal bleeding/spotting, vaginal discharge/dryness/pruritus,
decreased libido
Why should premenopausal females be supplemented with calcium and vitamin D when taking
Tamoxifen?
Tamoxifen causes decreased bone density
T/F:
Tamoxifen is teratogenic
True
What is the MOA of Fulvestrant?
Selective Estrogen Receptor Degrader (SERD)
How is Fluvestrant administered?
IM Injection
What are the side effects of Fluvestrant? Increased
LFTs, Injection site pain, hot flashes What class
does Anastrozole belong to?
Aromatase Inhibitor (AI)
What is the brand name of Anastrozole?
Arimidex
Anastrozole has higher risks of what complications?
Osteoporosis and CVD
What are the side effects of Anastrozole?
Hot flashes/night sweats, arthralgia/myalgia
What is contraindicated to use with any history of breast cancer?
Estrogen
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Real Exam Questions and Verified Correct
Answers
Which of the following can be given intrathecally if they are preservative-free? (select all
that apply)
A) Cytarabine
B) Methotrexate
C) Vincristine
D) Hydrocortisone
E) Thiotepa
A) Cytarabine
B) Methotrexate
D) Hydrocortisone
E) Thiotepa
What are the warnings and signs of Melanoma skin cancer?
"ABCDE"
-A: Asymmetry; when bisected, the 2 sides are not identical
-B: Border; Uneven edges, pigment fading off
-C: Color; Mixtures of brown, tan, black, & red
-D: Diameter; >/= 6 mm
-E: Evolving; New lesion or lesion changing in size, shape or color
Which class of drugs is considered first-line adjuvant treatment for premenopausal
females with hormone-sensitive cancer?
1|Page
,Selective Estrogen Receptor Modulator (SERM)
Which class of drugs is not useful as monotherapy for breast cancer in premenopausal
females?
Aromatase Inhibitors (AIs)
Which monoclonal antibody binds to the HER2 receptor in breast cancer to prevent
dimerization?
Trastuzumab
What is the brand name of Trastuzumab?
Herceptin
What are the SERMs used for breast cancer?
1) Tamoxifen
2) Raloxifene
Which of the following is a prodrug converted via CYP2D6?
Tamoxifen
What drug is preferred to counter the hot flashes/night sweats caused by Tamoxifen?
Venlafaxine
Which of the following is used for postmenopausal breast cancer prevention and
osteoporosis prevention/treatment?
Raloxifene
What are the boxed warnings of SERMs?
Increased risk of uterine or endometrial cancer and increased risk of thromboembolic
events
What are the side effects of SERMs?
2|Page
, Hot flashes/night sweats, vaginal bleeding/spotting, vaginal discharge/dryness/pruritus,
decreased libido
Why should premenopausal females be supplemented with calcium and vitamin D when taking
Tamoxifen?
Tamoxifen causes decreased bone density
T/F:
Tamoxifen is teratogenic
True
What is the MOA of Fulvestrant?
Selective Estrogen Receptor Degrader (SERD)
How is Fluvestrant administered?
IM Injection
What are the side effects of Fluvestrant? Increased
LFTs, Injection site pain, hot flashes What class
does Anastrozole belong to?
Aromatase Inhibitor (AI)
What is the brand name of Anastrozole?
Arimidex
Anastrozole has higher risks of what complications?
Osteoporosis and CVD
What are the side effects of Anastrozole?
Hot flashes/night sweats, arthralgia/myalgia
What is contraindicated to use with any history of breast cancer?
Estrogen
3|Page
