What is cotranslational translocation?
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The translocation of a secretory protein into the ER lumen that occurs while
the translocon-bound ribosome translates the mRNA encoding the nascent
protein.
, Describe glutathione.
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It is a reducing agent. The oxidized form of it, GSSG, creates disulfide
bonds in the ER lumen (acting together with PDI and Ero1).
Describe the 6 different pathways that sort proteins.
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1. If the protein contains no targeting sequence, then it will be sent to the
cytosol
2. It can be sent to the ER
3. It can be sent to the Mitochondria
4. It can be sent to the Chloroplast
5. It can be sent to the Nucleus
6. It can be sent to the Peroxisome
What is the "stop-transfer anchor sequence" or STA sequence?
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It is the internal hydrophobic part of the peptide sequence that will be the
transmembrane part of the integral membrane - it is a roughly 20 amino
acid hydrophobic sequence that forms an α-helix in the membrane.
How does the ER hold on to the incoming protein?
Give this one a try later!
The translocation of a secretory protein into the ER lumen that occurs while
the translocon-bound ribosome translates the mRNA encoding the nascent
protein.
, Describe glutathione.
Give this one a try later!
It is a reducing agent. The oxidized form of it, GSSG, creates disulfide
bonds in the ER lumen (acting together with PDI and Ero1).
Describe the 6 different pathways that sort proteins.
Give this one a try later!
1. If the protein contains no targeting sequence, then it will be sent to the
cytosol
2. It can be sent to the ER
3. It can be sent to the Mitochondria
4. It can be sent to the Chloroplast
5. It can be sent to the Nucleus
6. It can be sent to the Peroxisome
What is the "stop-transfer anchor sequence" or STA sequence?
Give this one a try later!
It is the internal hydrophobic part of the peptide sequence that will be the
transmembrane part of the integral membrane - it is a roughly 20 amino
acid hydrophobic sequence that forms an α-helix in the membrane.
How does the ER hold on to the incoming protein?
