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HESI Fundamentals Practice Questions 2026 – 212 Questions and Answers on Safety, Infection Control, Pharmacology & Legal/Ethical Nursing

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This document contains 212 comprehensive HESI Fundamentals practice questions with detailed answers and rationales for the 2026 exam, covering core nursing concepts and clinical decision-making skills . The content spans infection prevention (hand hygiene, sterile technique, chain of infection, NG tube placement verification, wound care sterility, catheter-associated infection risk), medication administration (IV vs PO pharmacokinetics, dosage calculations, five rights of medication administration, feeding tube medication flushing, antihypertensive continuation postoperatively), and fluid and electrolyte monitoring (sodium imbalance with prolonged NG suction, urine output documentation, dehydration assessment). The material also provides extensive review of perioperative care (informed consent, anticoagulant risk, operative permit protocol), client safety (fall prevention, orthostatic vital signs, bed rail positioning, ambulation techniques, gait belt use, elderly center of gravity changes), and emergency response principles (Good Samaritan Act, fire evacuation procedures, needle stick protocol). Ethical and legal topics include confidentiality, informed consent, minor consent laws, scope and standards of nursing practice, and boundary issues when caring for friends. Additional coverage includes mobility and immobility complications, venous thrombosis prevention, pressure injury prevention, nasogastric tube care, spiritual distress, communication techniques, therapeutic responses, grief counseling, and prioritization strategies using safety frameworks. The structured multiple-choice format mirrors HESI and NCLEX-style questioning and emphasizes prioritization, delegation, pharmacology application, legal protection, infection control, and clinical judgment. The material aligns with standard nursing fundamentals textbooks such as Potter & Perry Fundamentals of Nursing and HESI review resources, making it highly effective for first-year nursing students, practical nursing students, remediation students, and candidates preparing for HESI Fundamentals or NCLEX exams. This document may concern: • HESI Fundamentals 2026 • Nursing Fundamentals I • Foundations of Nursing Practice • Introduction to Professional Nursing • PN Fundamentals Course • Pre-Licensure RN Programs It is particularly relevant for: • ADN nursing students • BSN nursing students • Practical nursing students • Students preparing for HESI exit exams • Pre-NCLEX candidates Keywords: HESI fundamentals 2026, HESI practice questions nursing, infection control nursing, sterile technique procedures, chain of infection nursing, medication administration five rights, IV vs PO pharmacokinetics, nasogastric tube placement verification, venous thrombosis prevention exercises, postoperative consent protocol, Good Samaritan Act nursing, fire evacuation hospital procedures, fall prevention elderly clients, orthostatic vital signs assessment, gait belt ambulation technique, urinary catheter infection risk, wound care sterile saline protocol, feeding tube medication flushing, spiritual distress nursing care, therapeutic communication techniques

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HESI Fundamentals practice
Questions 2026 Exam All
Answers and Illustrations Given


When turning an immobile bedridden client without assistance, which

action by the nurse best ensures client safety?

A. Securely grasp the client's arm and leg.

B. Put bed rails up on the side of bed opposite from the nurse.

C. Correctly position and use a turn sheet.


D. Lower the head of the client's bed slowly. - 🧠 ANSWER ✔✔B

,Rationale: Because the nurse can only stand on one side of the bed, bed

rails should be up on the opposite side to ensure that the client does not fall

out of bed. Option A can cause client injury to the skin or joint. Options C

and D are useful techniques while turning a client but have less priority in

terms of safety than use of the bed rails.

The nurse identifies a potential for infection in a client with partial-thickness

(second-degree) and full-thickness (third-degree) burns. What intervention

has the highest priority in decreasing the client's risk of infection?

A. Administration of plasma expanders

B. Use of careful handwashing technique

C. Application of a topical antibacterial cream


D. Limiting visitors to the client with burns - 🧠 ANSWER ✔✔B


Rationale: Careful handwashing technique is the single most effective

intervention for the prevention of contamination to all clients. Option A

reverses the hypovolemia that initially accompanies burn trauma but is not

related to decreasing the proliferation of infective organisms. Options C and

D are recommended by various burn centers as possible ways to reduce

the chance of infection. Option B is a proven technique to prevent infection.

,The nurse is aware that malnutrition is a common problem among clients

served by a community health clinic for the homeless. Which laboratory

value is the most reliable indicator of chronic protein malnutrition?

A. Low serum albumin level

B. Low serum transferrin level

C. High hemoglobin level


D. High cholesterol level - 🧠 ANSWER ✔✔A


Rationale: Long-term protein deficiency is required to cause significantly

lowered serum albumin levels. Albumin is made by the liver only when

adequate amounts of amino acids (from protein breakdown) are available.

Albumin has a long half-life, so acute protein loss does not significantly

alter serum levels. Option B is a serum protein with a half-life of only 8 to

10 days, so it will drop with an acute protein deficiency. Options C and D

are not clinical measures of protein malnutrition.

In completing a client's preoperative routine, the nurse finds that the

operative permit is not signed. The client begins to ask more questions

about the surgical procedure. Which action should the nurse take next?

A. Witness the client's signature to the permit.


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, B. Answer the client's questions about the surgery.

C. Inform the surgeon that the operative permit is not signed and the client

has questions about the surgery.

D. Reassure the client that the surgeon will answer any questions before

the anesthesia is administered. - 🧠 ANSWER ✔✔C


Rationale: The surgeon should be informed immediately that the permit is

not signed. It is the surgeon's responsibility to explain the procedure to the

client and obtain the client's signature on the permit. Although the nurse

can witness an operative permit, the procedure must first be explained by

the health care provider or surgeon, including answering the client's

questions. The client's questions should be addressed before the permit is

signed.

The nurse is assessing several clients prior to surgery. Which factor in a

client's history poses the greatest threat for complications to occur during

surgery?

A. Taking birth control pills for the past 2 years

B. Taking anticoagulants for the past year

C. Recently completing antibiotic therapy

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