ONS CHEMOTHERAPY BIOTHERAPY EXAM
SCRIPT 2026 QUESTIONS AND VERIFIED
ANSWERS LATEST UPDATE
⩥ LESSON 1: Cell cycle. Answer: g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
⩥ mitosis. Answer: 4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
⩥ apoptosis. Answer: programmed cell death
⩥ hematopoiesis. Answer: formation of blood cells & how cells
differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
⩥ Principles of Biotherapy: p51-95 immunology. Answer: -defense
against foreign organisms, homeostasis (destroy aged cells), surveillance
,⩥ immune responses. Answer: innate: primary line of defense, non
specific, no memory
adaptive: secondary line of defence with specific memry
⩥ cytokines. Answer: -effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
⩥ vaccines for cancer prevention. Answer: -hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
⩥ filgrastim aka neupogen. Answer: SC or IV to derease infection in
patients with neutropenic fever associated with myelosuppressive
anticancer treatments for nonmyeloid malignancies
⩥ tbo-filgramstim/ pegfilgrastim. Answer: reduce duration of neutroenia
in patients with non myeloid malignancies
⩥ palifermin. Answer: IV to dec incidence of oral mucositis in patients
with hem malignanies before BMT
, ⩥ sargramostim. Answer: aka leukine - patients with AML following
chemo to shorten neutrophil recovery and reduce incidence of infection
⩥ IFN gamma. Answer: reduce frequency and severity o infections
related to granulomatous disease
⩥ aldeleukin. Answer: treat renal cell carcinoma and metastatic
melanoma
⩥ oprevelkin. Answer: prevent severe thrombocytopenia and refuce
need for platelet transfusions in patients with nonmyeloid malig
⩥ plerixafor. Answer: with filgrastim to mobilize hematopoeitc stem
cells for collection from peripheral blood of patients
⩥ sipuleucel. Answer: castrate resistant prostate cancer
⩥ rituximab. Answer: rituxan- treatment of relapsed or refractory low
grade follicular b cell NHL_ first line traetment in combo with chemo in
patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia,
rigors, dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
SCRIPT 2026 QUESTIONS AND VERIFIED
ANSWERS LATEST UPDATE
⩥ LESSON 1: Cell cycle. Answer: g1- increase in size
s- dna replicated
g2- cell enlarge and ready to divide
m phase- 2 hours
⩥ mitosis. Answer: 4 stages, prophase, metaphase, anaphase, telophase
-chemo targets certain points in the process
⩥ apoptosis. Answer: programmed cell death
⩥ hematopoiesis. Answer: formation of blood cells & how cells
differentiate
-myeloid: pre cells mature into RBCs, platelets and WBCs
-lymphoid: pre cells- mature into WBCS
⩥ Principles of Biotherapy: p51-95 immunology. Answer: -defense
against foreign organisms, homeostasis (destroy aged cells), surveillance
,⩥ immune responses. Answer: innate: primary line of defense, non
specific, no memory
adaptive: secondary line of defence with specific memry
⩥ cytokines. Answer: -effect growth and differentiation of WBC
-interferons, tumor necrosis factors, growth factos and interleukins
-small protein molecules released by cells throughout body providing
comunication between cells of the immune system
-regular antiboddy production and function of b cells
⩥ vaccines for cancer prevention. Answer: -hep B prevents hepatitis and
hepatocellular carcinoma
-hpv vaccine
⩥ filgrastim aka neupogen. Answer: SC or IV to derease infection in
patients with neutropenic fever associated with myelosuppressive
anticancer treatments for nonmyeloid malignancies
⩥ tbo-filgramstim/ pegfilgrastim. Answer: reduce duration of neutroenia
in patients with non myeloid malignancies
⩥ palifermin. Answer: IV to dec incidence of oral mucositis in patients
with hem malignanies before BMT
, ⩥ sargramostim. Answer: aka leukine - patients with AML following
chemo to shorten neutrophil recovery and reduce incidence of infection
⩥ IFN gamma. Answer: reduce frequency and severity o infections
related to granulomatous disease
⩥ aldeleukin. Answer: treat renal cell carcinoma and metastatic
melanoma
⩥ oprevelkin. Answer: prevent severe thrombocytopenia and refuce
need for platelet transfusions in patients with nonmyeloid malig
⩥ plerixafor. Answer: with filgrastim to mobilize hematopoeitc stem
cells for collection from peripheral blood of patients
⩥ sipuleucel. Answer: castrate resistant prostate cancer
⩥ rituximab. Answer: rituxan- treatment of relapsed or refractory low
grade follicular b cell NHL_ first line traetment in combo with chemo in
patients with response
-can treat severe rheumatoid arthritis
-can have severe reactions (hypotension, urticaria, angiodema, hypoxia,
rigors, dyspnea, chills, fever, nausea, rash, renal tox)
-premed with tylenol and benadryl
