ONS CHEMOTHERAPY IMMUNOTHERAPY CERTIFICATE EXAMINATION TEST QUESTIONS WITH VERIFIED ANSWERS 2026

ONS CHEMOTHERAPY IMMUNOTHERAPY
CERTIFICATE EXAMINATION TEST QUESTIONS
WITH VERIFIED ANSWERS 2026

◉ Define adjuvant therapy. Answer: Additional cancer treatment
given after the primary treatment to lower the risk that the cancer
reoccur


◉ 3 subcategories of alkylating agents: Answer: 1. Nitrogen
mustards
2. Platinum-based agents (do not possess an alkyl group but still
termed alkylating agents as they work similarly)
3. Nitrosoureas


◉ Common alkylating agents:. Answer: Cyclophosphamide
(Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)


◉ Common platinum-based agents:. Answer: Cisplatin (Platinol)
Carboplatin (Paraplatin)

,◉ What is unique about nitrosoureas agents?. Answer: Able to cross
the blood-brain barrier; can be effective in treating some brain
tumors


◉ Common nitrosoureas agents:. Answer: Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)


◉ Hypersensitivity can occur with late doses of:. Answer:
Carboplatin


◉ These agents are typically categorized as highly emetogenic:.
Answer: 1. Alkylating agents
2. Nitrosoureas


◉ Pre-administration labs for alkylating agents and nitrosoureas:.
Answer: BUN
Creatinine
CBC w/ diff


◉ What is the medication Mesna used for?. Answer: Bladder
protectant with administration of cyclophosphamide or ifosfamide

, ◉ Instruct pts receiving ________ to avoid exposure to cold air and
consuming cold fluids for 3-4 days following treatment. Answer:
Oxaliplatin


◉ How do antimetabolites function?. Answer: By blocking DNA and
RNA growth by interfering with enzymes needed for normal cell
metabolism


◉ Antimetabolites work in the ___ phase.. Answer: S


◉ Common side effects of antimetabolites:. Answer:
Myelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome


◉ Common antimetabolite drugs:. Answer: Azacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate