NRNP 6665 Final Exam Questions and
Answers (2026/2027) | Updated Review |
A+ Verified
Agomelatine -✓✓Brand: Valdoxan
-Melatonin multimodal (Mel-MM)
-Agonist at melatonergic 1 and melatonergic 2 receptors
-Antagonist at 5HT2C receptors
-Not FDA approved: Rx for Depression, Generalized anxiety disorder
-Initial 25 mg/day at bedtime; after 2 weeks can increase to 50 mg/day at bedtime
Amitriptyline (Elavil) -✓✓Tricyclic antidepressant.
Aripiprazole (Abilify) -✓✓Treatment for depression. Atypical antipsychotic.
"Dopamine stabilizer". Dopamine receptor antagonist in high concentration and
also stimulates increase of dopamine in low concentrations. Side effects: insomnia,
akathisia.
Brexpiprazole (Rexulti) -✓✓Treatment for depression. Atypical antipsychotic
Bupropion (Wellbutrin) -✓✓Antidepressant and smoking cessation aid, It can treat
depression and help people quit smoking. It can also prevent depression caused by
seasonal affective disorder (SAD).
Citalopram (Celexa) -✓✓Antidepressant, SSRI: 20-40 mg qd.
Clomipramine (Anafranil) -✓✓-Serotonin reuptake inhibitor (S-RI)
,-Tricyclic antidepressant (TCA)
-Parent drug is a potent serotonin reuptake inhibitor
Active metabolite is a potent norepinephrine/noradrenaline reuptake inhibitor
-Increases serotonergic neurotransmission by blocking the serotonin reuptake
pump (transporter), -Desensitization of serotonin receptors, especially serotonin
1A receptors
-Increases noradrenergic neurotransmission by blocking the norepinephrine
reuptake pump (transporter), -Desensitization of beta adrenergic receptors
-Dopamine is inactivated by norepinephrine reuptake in the frontal cortex
-Lacks dopamine transporters
-Increases dopamine neurotransmission in this part of the brain
**FDA Approved for Pediatrics in tx Obsessive-compulsive disorder (OCD) (ages
10 and older)
*Off-Label for Pediatric Use: Depression, Severe and treatment-resistant,
depression, Cataplexy syndrome, Anxiety, Insomnia,
Neuropathic pain/chronic pain
-Full therapeutic benefits may take 2-8 weeks
-Dosing: in Peds/Adolescents/Adults:
100-250mg/day
Cyamemazine (Tercian) -✓✓Treatment for depression.
-Known as cyamepromazine
-Typical antipsychotic drug of the phenothiazine class.
-Treatment for schizophrenia
and psychosis-associated
anxiety
-Behaves like an atypical
,antipsychotic, due to its
potent anxiolytic effects (5-HT2C) and lack of extrapyramidal side effects (5-
HT2A).
-Conventional antipsychotic (neuroleptic, phenothiazine, dopamine 2 antagonist,
serotonin dopamine antagonist)
-Commonly Prescribed for (not FDA approved):
-Schizophrenia
-Anxiety associated with psychosis (short-term)
-Anxiety associated with nonpsychotic disorders, including mood disorders and
personality disorders (short-term)
-Severe depression
-Bipolar disorder
-Other psychotic disorders
-Acute agitation/aggression (injection)
-Benzodiazepine withdrawal
Desiprimine (Norpramine) -✓✓Treats depression
Brand: Norpramin
-TCA
-Norepinephrine noradrenaline reuptake inhibitor.
-FDA approved for treating depression.
-Off-label: Anxiety, Insomnia,
Neuropathic pain/chronic pain, Treatment-resistant depression.
-More potent inhibitor of norepinephrine reuptake pump than serotonin reuptake
pump (serotonin transporter).
-May have immediate effects in treating insomnia or anxiety.
, -If it is not working within 6-8 weeks for depression, it may require a dosage
increase or it may not work at all
-100-200 mg/day (for depression)
50-150 mg/day (for chronic pain).
Desvenlafaxine (Pristiq) -✓✓Dual serotonin and norepinephrine reuptake
inhibitor-often classified as an antidepressant.
-FDA approved to tx MDD.
-Off-label: Vasomotor sx's, fibromyalgia, GAD, Social Anx d/o, panic d/o, PTSD,
PMDD
-Dopamine is inactivated by norepinephrine reuptake in frontal cortex (which lack
dopamine transporters) med can increase dopamine neurotransmission in this part
of the brain
-
Risperidone (Risperdal) -✓✓Atypical Antipsychotic (most "typical" of atypicals)
Side effects: EPS (dose-dependent), TD, significant increases in PRL (check PRL
levels)
--> most dopaminergic of Atypicals
IM formulation is available
Amphetamines -✓✓drugs that stimulate neural activity, causing speeded-up body
functions and associated energy and mood changes
Dextroamphetamine -✓✓CNS stimulant
*Mech*: Inc catecholamines at the synaptic cleft, especially NE and dopamine.
Answers (2026/2027) | Updated Review |
A+ Verified
Agomelatine -✓✓Brand: Valdoxan
-Melatonin multimodal (Mel-MM)
-Agonist at melatonergic 1 and melatonergic 2 receptors
-Antagonist at 5HT2C receptors
-Not FDA approved: Rx for Depression, Generalized anxiety disorder
-Initial 25 mg/day at bedtime; after 2 weeks can increase to 50 mg/day at bedtime
Amitriptyline (Elavil) -✓✓Tricyclic antidepressant.
Aripiprazole (Abilify) -✓✓Treatment for depression. Atypical antipsychotic.
"Dopamine stabilizer". Dopamine receptor antagonist in high concentration and
also stimulates increase of dopamine in low concentrations. Side effects: insomnia,
akathisia.
Brexpiprazole (Rexulti) -✓✓Treatment for depression. Atypical antipsychotic
Bupropion (Wellbutrin) -✓✓Antidepressant and smoking cessation aid, It can treat
depression and help people quit smoking. It can also prevent depression caused by
seasonal affective disorder (SAD).
Citalopram (Celexa) -✓✓Antidepressant, SSRI: 20-40 mg qd.
Clomipramine (Anafranil) -✓✓-Serotonin reuptake inhibitor (S-RI)
,-Tricyclic antidepressant (TCA)
-Parent drug is a potent serotonin reuptake inhibitor
Active metabolite is a potent norepinephrine/noradrenaline reuptake inhibitor
-Increases serotonergic neurotransmission by blocking the serotonin reuptake
pump (transporter), -Desensitization of serotonin receptors, especially serotonin
1A receptors
-Increases noradrenergic neurotransmission by blocking the norepinephrine
reuptake pump (transporter), -Desensitization of beta adrenergic receptors
-Dopamine is inactivated by norepinephrine reuptake in the frontal cortex
-Lacks dopamine transporters
-Increases dopamine neurotransmission in this part of the brain
**FDA Approved for Pediatrics in tx Obsessive-compulsive disorder (OCD) (ages
10 and older)
*Off-Label for Pediatric Use: Depression, Severe and treatment-resistant,
depression, Cataplexy syndrome, Anxiety, Insomnia,
Neuropathic pain/chronic pain
-Full therapeutic benefits may take 2-8 weeks
-Dosing: in Peds/Adolescents/Adults:
100-250mg/day
Cyamemazine (Tercian) -✓✓Treatment for depression.
-Known as cyamepromazine
-Typical antipsychotic drug of the phenothiazine class.
-Treatment for schizophrenia
and psychosis-associated
anxiety
-Behaves like an atypical
,antipsychotic, due to its
potent anxiolytic effects (5-HT2C) and lack of extrapyramidal side effects (5-
HT2A).
-Conventional antipsychotic (neuroleptic, phenothiazine, dopamine 2 antagonist,
serotonin dopamine antagonist)
-Commonly Prescribed for (not FDA approved):
-Schizophrenia
-Anxiety associated with psychosis (short-term)
-Anxiety associated with nonpsychotic disorders, including mood disorders and
personality disorders (short-term)
-Severe depression
-Bipolar disorder
-Other psychotic disorders
-Acute agitation/aggression (injection)
-Benzodiazepine withdrawal
Desiprimine (Norpramine) -✓✓Treats depression
Brand: Norpramin
-TCA
-Norepinephrine noradrenaline reuptake inhibitor.
-FDA approved for treating depression.
-Off-label: Anxiety, Insomnia,
Neuropathic pain/chronic pain, Treatment-resistant depression.
-More potent inhibitor of norepinephrine reuptake pump than serotonin reuptake
pump (serotonin transporter).
-May have immediate effects in treating insomnia or anxiety.
, -If it is not working within 6-8 weeks for depression, it may require a dosage
increase or it may not work at all
-100-200 mg/day (for depression)
50-150 mg/day (for chronic pain).
Desvenlafaxine (Pristiq) -✓✓Dual serotonin and norepinephrine reuptake
inhibitor-often classified as an antidepressant.
-FDA approved to tx MDD.
-Off-label: Vasomotor sx's, fibromyalgia, GAD, Social Anx d/o, panic d/o, PTSD,
PMDD
-Dopamine is inactivated by norepinephrine reuptake in frontal cortex (which lack
dopamine transporters) med can increase dopamine neurotransmission in this part
of the brain
-
Risperidone (Risperdal) -✓✓Atypical Antipsychotic (most "typical" of atypicals)
Side effects: EPS (dose-dependent), TD, significant increases in PRL (check PRL
levels)
--> most dopaminergic of Atypicals
IM formulation is available
Amphetamines -✓✓drugs that stimulate neural activity, causing speeded-up body
functions and associated energy and mood changes
Dextroamphetamine -✓✓CNS stimulant
*Mech*: Inc catecholamines at the synaptic cleft, especially NE and dopamine.
