EXAM VERSION OF (2026-2027) With
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, Which pathway is associated with hyperprolactinemia - correct ans:the tuberoinfundibular pathway
Which pathway is associated with positive symptoms - correct ans:the mesolimbic pathway
extrapyramidal symptoms - correct ans:*group of symptoms related to motor control and coordination
(dystonia, akathisia, tardive dyskinesia, bradykinesia, tremors, parkinsonism)
* caused by dopamine excess in the basal ganglia
Second-Generation Antipsychotics (SGAs- atypical) - correct ans:* are serotonin-dopamine antagonists
*treat both positive and negative symptoms
Does stimulation of 5HT1A increase or decrease dopamine levels - correct ans:increase
Does stimulation of 5HT2A increase or decrease dopamine levels - correct ans:decrease
SGA's the "pines" - correct ans:Clozapine (Clozaril), Asenapine (Saphris), Olanzapine (Zyprexa),
Quetiapine (Seroquel)
PEARLS:
-more potently bind to 5HT than DA
-sedation is common
-lowest risk of EPS
-high risk for weight gain and metabolic abnormalities
which pine should not be used in acute phase of schizophrenia - correct ans:clozapine
which pine is the best tolerated - correct ans:olanzapine
which pine should be held if ANC (absolute neutrophile count) is < 1500 - correct ans:clozapine