NBME CBSE (USMLE Step 1) –EXAM Newest 2026
Complete Questions and Correct Detailed
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70yo M dies in a motor vehicle Tubular adenoma
collision. Was undergoing evaluation
for occult blood in the stool. Photo
of transverse colon shown. Dx?
38yo M with 1-week hx of watery, Loratadine
itchy eyes and a runny nose. Physical
shows inflamed nasal mucosa. No
congestion in lower lung.
Pharmacotherapy?
16yo girl with 3-day hx of fever, IgM
nonproductive cough, and fatigue. T
38.3, P 88/min, BP 102-70. PE shows
pale conjunctivae. CXR shows
bilateral interstitial infiltrates. Blood
spontaenously agglutinates while
awaiting transport to the laboratory.
Antibody isotypes causing
agglutination?
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,6/17/26, 9:38 AM NBME CBSE (USMLE Step 1) –EXAM Newest 2026 Complete Questions and Correct Detailed Answers (Verified Answers) |Alread…
24yo M with small tender blisters on HSV-2
his penis 3 days after unprotected
sex. Photograph shown. Causal
agent?
42yo F with 3-year hx of an Rosacea
intermittent facial rash, including the
forehead, eyelids, nose, and cheeks.
Rash seems to be getting worse
since she moved from New York to
Florida last year. Spicy foods
precipitate a flushing reaction that
seems to exacerbate the rash. PE
shows erythema over the nose and
cheeks, with scattered
telangiectasias and a few papules.
Dx?
53yo M returned from Africa, has Malaria
fever, headache, and abdominal
discomfort. Received appropriate
vaccinations prior to the trip. T 39.4C.
A wright-stained peripheral smear
shown. Dx?
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, 6/17/26, 9:38 AM NBME CBSE (USMLE Step 1) –EXAM Newest 2026 Complete Questions and Correct Detailed Answers (Verified Answers) |Alread…
68yo F with T2DM and hypertension Lisinopril
that has been poorly controlled
despite hydrochlorothiazide
treatment. BP 150/96, Labs show
serum glucose concentration of 130
and proteinuria. In addition to
current Rx, which is most
appropriate pharmacotherapy?
66yo M with stage IV colon cancer Loperamide
with 3-day hx of severe diarrhea
after receiving chemotherapy with
fluorouracil, leucovorin, and
Irinotecan. prescribed opioid
antidiarrheal agent with no CNS
effects. Which med?
35yo M in ED with 2-hour hx of sever Activation of adenylyl cyclase
fatigue and dizziness. Had profuse,
watery diarrhea for 8 hours despite a
lack of oral intake. Recently returned
from a medical relief trip to a remove
village in Honduras. T 36.7 C, P
122/min, BP 90/50. PE shows dry skin
and decreased capillary refill. Stool
for occult blood is negative; stool is
gray and turbid. Gram stain shows
gram-negative, comma-shaped
bacteria; no erythrocytes of
leukocytes. MOA of toxin?
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