NBME CBSE (USMLE Step 1) TESTBANK EXAM Questions with 100%
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2025|2026 EXAM UPDATE
70yo M dies in a motor vehicle collision. Was undergoing evaluation for occult blood in the stool. Photo
of transverse colon shown. Dx? - (ANSWER)Tubular adenoma
38yo M with 1-week hx of watery, itchy eyes and a runny nose. Physical shows inflamed nasal mucosa.
No congestion in lower lung. Pharmacotherapy? - (ANSWER)Loratadine
16yo girl with 3-day hx of fever, nonproductive cough, and fatigue. T 38.3, P 88/min, BP 102-70. PE
shows pale conjunctivae. CXR shows bilateral interstitial infiltrates. Blood spontaenously agglutinates
while awaiting transport to the laboratory. Antibody isotypes causing agglutination? - (ANSWER)IgM
24yo M with small tender blisters on his penis 3 days after unprotected sex. Photograph shown. Causal
agent? - (ANSWER)HSV-2
42yo F with 3-year hx of an intermittent facial rash, including the forehead, eyelids, nose, and cheeks.
Rash seems to be getting worse since she moved from New York to Florida last year. Spicy foods
precipitate a flushing reaction that seems to exacerbate the rash. PE shows erythema over the nose and
cheeks, with scattered telangiectasias and a few papules. Dx? - (ANSWER)Rosacea
53yo M returned from Africa, has fever, headache, and abdominal discomfort. Received appropriate
vaccinations prior to the trip. T 39.4C. A wright-stained peripheral smear shown. Dx? - (ANSWER)Malaria
68yo F with T2DM and hypertension that has been poorly controlled despite hydrochlorothiazide
treatment. BP 150/96, Labs show serum glucose concentration of 130 and proteinuria. In addition to
current Rx, which is most appropriate pharmacotherapy? - (ANSWER)Lisinopril
66yo M with stage IV colon cancer with 3-day hx of severe diarrhea after receiving chemotherapy with
fluorouracil, leucovorin, and Irinotecan. prescribed opioid antidiarrheal agent with no CNS effects.
Which med? - (ANSWER)Loperamide
,NBME CBSE (USMLE Step 1) TESTBANK EXAM Questions with 100%
Correct Answers | Verified || ACTUAL EXAM 2026 TEST!! Graded A+ |
2025|2026 EXAM UPDATE
35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had profuse, watery diarrhea for 8 hours
despite a lack of oral intake. Recently returned from a medical relief trip to a remove village in
Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows dry skin and decreased capillary refill. Stool for
occult blood is negative; stool is gray and turbid. Gram stain shows gram-negative, comma-shaped
bacteria; no erythrocytes of leukocytes. MOA of toxin? - (ANSWER)Activation of adenylyl cyclase
59yo F with gradual onset of lack of muscle control in her left arm and leg. Sx 1 mo ago after dx with
metastatic breast cancer. PE shows ataxia of left upper and lower extremities. Muscle strength, DTR,
sensation, proprioception normal. Metastatic tumor in which location? - (ANSWER)cerebellum
Newborn delivered at 38 weeks' gestation weighs 1800 g. PE shows petechial rash, microcephaly, and
hepatosplenomegaly. Serologic test for CMV: IgG + in mother, + in newborn; IGM - in mother, + in
newborn. Explanation? - (ANSWER)Congenital cytomegalovirus infection
Female newborn is delivered at 38 weeks' gestation. Apgar 8 and 8 at 1/5 min. PE shows a bulging,
fluod0filled mass approximately 5 cm in diameter in the midline over the lumbosacral region. No
spontaneous movements of the lower extremities. Abnormality most likely occurred because of
abnormal development during which periods of postconception (in days)? - (ANSWER)15 to 40
64yo M in ED 3 hours after SOB with exertion and extreme fatigue. Has ischemic heart disease. P
125/min, BP 105/60. ECG shows atrial fibrillation. Intravenous ibutilide is administered. Ten minutes
later, ECG shows normal sinus rhythm. Risk for which drug effect in the next 6 hours? -
(ANSWER)torsades de pointes
65yo F with 20-year hx of osteoarthritis of the hands now has pain radiating down the distal anterior
thigh, knee, medial leg, and food. Bony outgrowth of vertebrae compressing one of the spinal nerves is
suspected. Nerve root in which intervertebral foramina is effected? - (ANSWER)L3 to L4
38yo M with 3-year hx of T2DM. Taking an oral antihyperglycemic agent, he has tried diet and exercise.
BMI 32. PE normal. Hb A1c is 10%. Physician recommends initiation of insulin injections. Responds, "I
,NBME CBSE (USMLE Step 1) TESTBANK EXAM Questions with 100%
Correct Answers | Verified || ACTUAL EXAM 2026 TEST!! Graded A+ |
2025|2026 EXAM UPDATE
know that insulin would help control my blood sugar. But a lot of people in my family have diabetes, and
insulin made them really sick at times. Patient is at which stage of change? - (ANSWER)contemplation
24yo M with 2-day history of an itchy rash on his arms and legs. Returned from a camping trip in the
woods 5 days ago. PE shows edematous, erythematous rash with linear vesicles. Cause is activation of
which cell types? - (ANSWER)T lymphocytes
70yo M from china with poorly differentiated monoclonal carcinoma of the nasopharynx. DNA probes of
neoplastic cells are most likely to detect genome of which virus? - (ANSWER)EBV
Epidemiologic study of aniline dye, 500 workers with bladder cancer and 200 workers without. Exposed
to aniline dyes/Have Bladder cancer: Yes/Yes (250), Yes/No (50), No/Yes (250), No/No (150). Odds ratio?
- (ANSWER)3
24yo M with hx of IVDA could not be aroused. Friend reports that the patient injected himself with a
drug 6 hours ago. Labs show drug concentration of 0.3. Assuming first-order one-compartment kinetics,
has a half-life of 2 hours, and a volume of distribution of 200 L in this patient. What is quantity of drug
(in mg) injected? - (ANSWER)480
Compound is taken up by bacterial cells. No energy is necessary for uptake, and the compound is not
concentrated in the cell. Which describes this mechanism of transport? - (ANSWER)carrier-mediated
diffusion
Newborn has male genital ducts but female external genitalia. Cytogenetic analysis shows a 46,XY
karyotype, and genetic testing shows a mutation of the gene encoding 5alpha-reductase. In absence of
this mutation, labia majora would have been? - (ANSWER)scrotum
Study designed to evaluate the efficacy of coenzyme Q10 in improving cardiac output in patients with
CHF. Sixty patients with CHF are recruited. Each assigned by coin toss to one of two groups. Design? -
(ANSWER)randomized clinical trial
, NBME CBSE (USMLE Step 1) TESTBANK EXAM Questions with 100%
Correct Answers | Verified || ACTUAL EXAM 2026 TEST!! Graded A+ |
2025|2026 EXAM UPDATE
12yo boy immersed up to his neck in 60F water for 20 minutes. Physiological changes? -
(ANSWER)Central blood volume INCREASED, ADH (vasopressin) DECREASED, Atrial Natriuretic Peptide
INCREASED? C (block3, q23)
Randomized controlled study of 2000 patients with insomnia is conducted to evaluate the efficacy of a
new medication to treat this condition. Ten subjects from both the control and treatment groups do not
complete the study are not included in the analysis. Treatment group able to fall asleep 5 minutes faster
than control (p=0.001). Neither group report an improvement in quality of life. Conclude that new med
is efficacious in treating insomnia. Type of error? - (ANSWER)Failure to distinguish between statistical
significance and clinical significance
18mo girl. Separation of the umbilical cord was delayed after birth. Has had four severe skin infections
Staphylococcus aureus; No pus formation at infection sites. Persistent leukocytosis in absence of
infection. Mechanisms impaired? - (ANSWER)leukocyte adhesion and transmigration
50yo M with increasing cough for 6 month and hemoptysis for 1 week. Smoked 1 pack per day for 32
years. Plays squash, swims. CXR shows a 3 x 4-cm hilar mass. Cytologic examination of sputum shows a
non-small cell carcinoma. Tells patient he has lung cancer. The patient responds, "How can this be
happening to m? I eat right and exercise." Appropriate response? - (ANSWER)"It must be difficult for you
to accept this diagnosis when you feel healthy."
32yo M with 6-month hx of low back pain and stiffness, worse in morning and improve during the day;
the pain radiates to his buttocks but not down his legs. Back stiffness if he sits for prolonged periods.
Which to confirm diagnosis? - (ANSWER)X-rays of the sacroiliac joints
17yo boy with 8-kg weight gain during the past year. No medical illness. BMI is 32. He asks, "Do you
think that my weight gain is inherited from my father?" Appropriate response? - (ANSWER)"Yes, your
weight gain can be caused by genes and environment combined."
Correct Answers | Verified || ACTUAL EXAM 2026 TEST!! Graded A+ |
2025|2026 EXAM UPDATE
70yo M dies in a motor vehicle collision. Was undergoing evaluation for occult blood in the stool. Photo
of transverse colon shown. Dx? - (ANSWER)Tubular adenoma
38yo M with 1-week hx of watery, itchy eyes and a runny nose. Physical shows inflamed nasal mucosa.
No congestion in lower lung. Pharmacotherapy? - (ANSWER)Loratadine
16yo girl with 3-day hx of fever, nonproductive cough, and fatigue. T 38.3, P 88/min, BP 102-70. PE
shows pale conjunctivae. CXR shows bilateral interstitial infiltrates. Blood spontaenously agglutinates
while awaiting transport to the laboratory. Antibody isotypes causing agglutination? - (ANSWER)IgM
24yo M with small tender blisters on his penis 3 days after unprotected sex. Photograph shown. Causal
agent? - (ANSWER)HSV-2
42yo F with 3-year hx of an intermittent facial rash, including the forehead, eyelids, nose, and cheeks.
Rash seems to be getting worse since she moved from New York to Florida last year. Spicy foods
precipitate a flushing reaction that seems to exacerbate the rash. PE shows erythema over the nose and
cheeks, with scattered telangiectasias and a few papules. Dx? - (ANSWER)Rosacea
53yo M returned from Africa, has fever, headache, and abdominal discomfort. Received appropriate
vaccinations prior to the trip. T 39.4C. A wright-stained peripheral smear shown. Dx? - (ANSWER)Malaria
68yo F with T2DM and hypertension that has been poorly controlled despite hydrochlorothiazide
treatment. BP 150/96, Labs show serum glucose concentration of 130 and proteinuria. In addition to
current Rx, which is most appropriate pharmacotherapy? - (ANSWER)Lisinopril
66yo M with stage IV colon cancer with 3-day hx of severe diarrhea after receiving chemotherapy with
fluorouracil, leucovorin, and Irinotecan. prescribed opioid antidiarrheal agent with no CNS effects.
Which med? - (ANSWER)Loperamide
,NBME CBSE (USMLE Step 1) TESTBANK EXAM Questions with 100%
Correct Answers | Verified || ACTUAL EXAM 2026 TEST!! Graded A+ |
2025|2026 EXAM UPDATE
35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had profuse, watery diarrhea for 8 hours
despite a lack of oral intake. Recently returned from a medical relief trip to a remove village in
Honduras. T 36.7 C, P 122/min, BP 90/50. PE shows dry skin and decreased capillary refill. Stool for
occult blood is negative; stool is gray and turbid. Gram stain shows gram-negative, comma-shaped
bacteria; no erythrocytes of leukocytes. MOA of toxin? - (ANSWER)Activation of adenylyl cyclase
59yo F with gradual onset of lack of muscle control in her left arm and leg. Sx 1 mo ago after dx with
metastatic breast cancer. PE shows ataxia of left upper and lower extremities. Muscle strength, DTR,
sensation, proprioception normal. Metastatic tumor in which location? - (ANSWER)cerebellum
Newborn delivered at 38 weeks' gestation weighs 1800 g. PE shows petechial rash, microcephaly, and
hepatosplenomegaly. Serologic test for CMV: IgG + in mother, + in newborn; IGM - in mother, + in
newborn. Explanation? - (ANSWER)Congenital cytomegalovirus infection
Female newborn is delivered at 38 weeks' gestation. Apgar 8 and 8 at 1/5 min. PE shows a bulging,
fluod0filled mass approximately 5 cm in diameter in the midline over the lumbosacral region. No
spontaneous movements of the lower extremities. Abnormality most likely occurred because of
abnormal development during which periods of postconception (in days)? - (ANSWER)15 to 40
64yo M in ED 3 hours after SOB with exertion and extreme fatigue. Has ischemic heart disease. P
125/min, BP 105/60. ECG shows atrial fibrillation. Intravenous ibutilide is administered. Ten minutes
later, ECG shows normal sinus rhythm. Risk for which drug effect in the next 6 hours? -
(ANSWER)torsades de pointes
65yo F with 20-year hx of osteoarthritis of the hands now has pain radiating down the distal anterior
thigh, knee, medial leg, and food. Bony outgrowth of vertebrae compressing one of the spinal nerves is
suspected. Nerve root in which intervertebral foramina is effected? - (ANSWER)L3 to L4
38yo M with 3-year hx of T2DM. Taking an oral antihyperglycemic agent, he has tried diet and exercise.
BMI 32. PE normal. Hb A1c is 10%. Physician recommends initiation of insulin injections. Responds, "I
,NBME CBSE (USMLE Step 1) TESTBANK EXAM Questions with 100%
Correct Answers | Verified || ACTUAL EXAM 2026 TEST!! Graded A+ |
2025|2026 EXAM UPDATE
know that insulin would help control my blood sugar. But a lot of people in my family have diabetes, and
insulin made them really sick at times. Patient is at which stage of change? - (ANSWER)contemplation
24yo M with 2-day history of an itchy rash on his arms and legs. Returned from a camping trip in the
woods 5 days ago. PE shows edematous, erythematous rash with linear vesicles. Cause is activation of
which cell types? - (ANSWER)T lymphocytes
70yo M from china with poorly differentiated monoclonal carcinoma of the nasopharynx. DNA probes of
neoplastic cells are most likely to detect genome of which virus? - (ANSWER)EBV
Epidemiologic study of aniline dye, 500 workers with bladder cancer and 200 workers without. Exposed
to aniline dyes/Have Bladder cancer: Yes/Yes (250), Yes/No (50), No/Yes (250), No/No (150). Odds ratio?
- (ANSWER)3
24yo M with hx of IVDA could not be aroused. Friend reports that the patient injected himself with a
drug 6 hours ago. Labs show drug concentration of 0.3. Assuming first-order one-compartment kinetics,
has a half-life of 2 hours, and a volume of distribution of 200 L in this patient. What is quantity of drug
(in mg) injected? - (ANSWER)480
Compound is taken up by bacterial cells. No energy is necessary for uptake, and the compound is not
concentrated in the cell. Which describes this mechanism of transport? - (ANSWER)carrier-mediated
diffusion
Newborn has male genital ducts but female external genitalia. Cytogenetic analysis shows a 46,XY
karyotype, and genetic testing shows a mutation of the gene encoding 5alpha-reductase. In absence of
this mutation, labia majora would have been? - (ANSWER)scrotum
Study designed to evaluate the efficacy of coenzyme Q10 in improving cardiac output in patients with
CHF. Sixty patients with CHF are recruited. Each assigned by coin toss to one of two groups. Design? -
(ANSWER)randomized clinical trial
, NBME CBSE (USMLE Step 1) TESTBANK EXAM Questions with 100%
Correct Answers | Verified || ACTUAL EXAM 2026 TEST!! Graded A+ |
2025|2026 EXAM UPDATE
12yo boy immersed up to his neck in 60F water for 20 minutes. Physiological changes? -
(ANSWER)Central blood volume INCREASED, ADH (vasopressin) DECREASED, Atrial Natriuretic Peptide
INCREASED? C (block3, q23)
Randomized controlled study of 2000 patients with insomnia is conducted to evaluate the efficacy of a
new medication to treat this condition. Ten subjects from both the control and treatment groups do not
complete the study are not included in the analysis. Treatment group able to fall asleep 5 minutes faster
than control (p=0.001). Neither group report an improvement in quality of life. Conclude that new med
is efficacious in treating insomnia. Type of error? - (ANSWER)Failure to distinguish between statistical
significance and clinical significance
18mo girl. Separation of the umbilical cord was delayed after birth. Has had four severe skin infections
Staphylococcus aureus; No pus formation at infection sites. Persistent leukocytosis in absence of
infection. Mechanisms impaired? - (ANSWER)leukocyte adhesion and transmigration
50yo M with increasing cough for 6 month and hemoptysis for 1 week. Smoked 1 pack per day for 32
years. Plays squash, swims. CXR shows a 3 x 4-cm hilar mass. Cytologic examination of sputum shows a
non-small cell carcinoma. Tells patient he has lung cancer. The patient responds, "How can this be
happening to m? I eat right and exercise." Appropriate response? - (ANSWER)"It must be difficult for you
to accept this diagnosis when you feel healthy."
32yo M with 6-month hx of low back pain and stiffness, worse in morning and improve during the day;
the pain radiates to his buttocks but not down his legs. Back stiffness if he sits for prolonged periods.
Which to confirm diagnosis? - (ANSWER)X-rays of the sacroiliac joints
17yo boy with 8-kg weight gain during the past year. No medical illness. BMI is 32. He asks, "Do you
think that my weight gain is inherited from my father?" Appropriate response? - (ANSWER)"Yes, your
weight gain can be caused by genes and environment combined."
