Running head: GOUTY ARTHRITIS CASE STUDY 1
Gouty Arthritis Case
Study Student Name
Walden University
NURS-6501N Advanced Pathophysiology.
July 26, 2020
, GOUTY ARTHRITIS CASE STUDY 2
Gouty Arthritis Case Study
The symptoms of gout were identified and documented in 2640 BC. Known as the
"disease of kings" gout was attributed to a lifestyle that was only affordable to the affluent
(Tang, 2018). Today, advances in science have offered a deeper understanding of the
pathophysiology and subsequent treatment of this disease. Gout is inflammatory arthritis that
occurs when monosodium urate crystals deposit into a joint. Common symptoms are redness,
swelling, and tenderness (McCance & Huether, 2019). Below is a case review of a 58-year-old
obese white male who presented to the emergency department with the chief complaint of fever,
chills, pain, and swelling in the right great toe.
Neurological and Musculoskeletal Pathophysiologic Processes
The underlining cause of gout is elevated uric acid in the plasma. Hyperuricemia results
in sharp crystals forming in areas of slow blood flow such as joints and kidneys. These crystals
occur when uric acid loses a proton to become urate ion, which binds with sodium to form
monosodium crystals (MSU). Hyperuricemia can result from increased purines consumption,
increased production of purines, decreased clearance of uric acid, obesity, diabetes,
chemotherapy, genetic predisposition, kidney disease, and medications such as thiazide diuretics
and aspirin (McCance & Huether, 2019). In the case study, the patient is experiencing podagra,
where the first metatarsal is inflamed, demonstrated by pain, redness, swelling, and fever.
Macrophage released in response to urate crystal resulting in further inflammatory response by
the signal protein interleukin 1B, which activates other immune cells to the joint. This
inflammatory response by white blood cells is an attempt to eliminate uric acid. During this
process, pyrexia will occur to improve the immunological function of the body. The
Gouty Arthritis Case
Study Student Name
Walden University
NURS-6501N Advanced Pathophysiology.
July 26, 2020
, GOUTY ARTHRITIS CASE STUDY 2
Gouty Arthritis Case Study
The symptoms of gout were identified and documented in 2640 BC. Known as the
"disease of kings" gout was attributed to a lifestyle that was only affordable to the affluent
(Tang, 2018). Today, advances in science have offered a deeper understanding of the
pathophysiology and subsequent treatment of this disease. Gout is inflammatory arthritis that
occurs when monosodium urate crystals deposit into a joint. Common symptoms are redness,
swelling, and tenderness (McCance & Huether, 2019). Below is a case review of a 58-year-old
obese white male who presented to the emergency department with the chief complaint of fever,
chills, pain, and swelling in the right great toe.
Neurological and Musculoskeletal Pathophysiologic Processes
The underlining cause of gout is elevated uric acid in the plasma. Hyperuricemia results
in sharp crystals forming in areas of slow blood flow such as joints and kidneys. These crystals
occur when uric acid loses a proton to become urate ion, which binds with sodium to form
monosodium crystals (MSU). Hyperuricemia can result from increased purines consumption,
increased production of purines, decreased clearance of uric acid, obesity, diabetes,
chemotherapy, genetic predisposition, kidney disease, and medications such as thiazide diuretics
and aspirin (McCance & Huether, 2019). In the case study, the patient is experiencing podagra,
where the first metatarsal is inflamed, demonstrated by pain, redness, swelling, and fever.
Macrophage released in response to urate crystal resulting in further inflammatory response by
the signal protein interleukin 1B, which activates other immune cells to the joint. This
inflammatory response by white blood cells is an attempt to eliminate uric acid. During this
process, pyrexia will occur to improve the immunological function of the body. The
