Macromolecule that may bind drugs if albumin sites become saturated
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Lipoproteins
fraction unbound =
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(unbound drug concentration in plasma / total drug concentration in
plasma) x 100%
In general, drugs that are highly bound to plasma protein have what effect on overall
drug clearance (metabolism + excretion)?
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reduced overall drug clearance
Method features of ultrafiltration
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Not temperature controlled
Rapid (< 1 hr)
High throughput
What is the effect of reduced plasma protein binding on bound drug concentration?
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decreases
, a large complex that will not cross the capillary wall
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protein-bound drug
Alpha-1 acid glycoprotein (AAG) levels in patients may be increased due to...
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due to the host's acute-phase response to infection, trauma, inflammatory
processes, and some malignant diseases
(Example: Imipramine)
Apparent volume of distribution depends on ________ and ________.
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plasma and tissue protein binding
________ drug will diffuse freely between the plasma and extracellular water.
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free
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Lipoproteins
fraction unbound =
,Give this one a try later!
(unbound drug concentration in plasma / total drug concentration in
plasma) x 100%
In general, drugs that are highly bound to plasma protein have what effect on overall
drug clearance (metabolism + excretion)?
Give this one a try later!
reduced overall drug clearance
Method features of ultrafiltration
Give this one a try later!
Not temperature controlled
Rapid (< 1 hr)
High throughput
What is the effect of reduced plasma protein binding on bound drug concentration?
Give this one a try later!
decreases
, a large complex that will not cross the capillary wall
Give this one a try later!
protein-bound drug
Alpha-1 acid glycoprotein (AAG) levels in patients may be increased due to...
Give this one a try later!
due to the host's acute-phase response to infection, trauma, inflammatory
processes, and some malignant diseases
(Example: Imipramine)
Apparent volume of distribution depends on ________ and ________.
Give this one a try later!
plasma and tissue protein binding
________ drug will diffuse freely between the plasma and extracellular water.
Give this one a try later!
free
