DOSAGE COMPENSATION
-
DNA
Methylation
-
1) Prevents
binding of To to promote
I
2) Recruits MBD proteins which requit
chromatin
remodelling
4 Repressive chromatin
complexes
changes patterns of t donor & accepto
groove >
-
non polar
Histone proteins H2A HISTONE 1 IS Heteroch
essential
·
A LINKER G prevents
↓ linker H2B
DNA HISTONE
H3 TYPE 1) fACU
for proper
TYPE 2) CONS
H4 chromosome Condensation
& Euchroma
=
3
·
Available to G Allows ifs
be modifieda access the
by protein
* METHYLATION
S
, * ACETYLATION
A
Phosphorylation
A
Ubiquitination of lysine
↳ Arganine
most
, Trimethylation of
lysine 27 histone 3 (H3K27) >
-
heterochrom
PCR2 Recognises & deposits
targets methyl group
[ Recognised by PCRI which binds to the chromatin
G it is a remodeller complex
They play an important role in dosage compensation
In mammals >
-
Shut off 1 X chromosome
Flies upregulate their X chromosome (XY)
· Heterochromatin
protein
I
& H3K9Me] chem mod = m
-
chromodomain
which
recognises
H3K9Me C anchors
HPI to that region
4 once bound can dimerize
bringing nucleosomes closer
together
G Recruits histone Methyltransferases
SWI / SNF Chromatin remodeler recognises
4 ↳ ATP dependent
Destabilizes/repositions
mechanism
nucleosomes >
-
access to pro
>
- RNA Pol
>
-
Basal TF
-
DNA
Methylation
-
1) Prevents
binding of To to promote
I
2) Recruits MBD proteins which requit
chromatin
remodelling
4 Repressive chromatin
complexes
changes patterns of t donor & accepto
groove >
-
non polar
Histone proteins H2A HISTONE 1 IS Heteroch
essential
·
A LINKER G prevents
↓ linker H2B
DNA HISTONE
H3 TYPE 1) fACU
for proper
TYPE 2) CONS
H4 chromosome Condensation
& Euchroma
=
3
·
Available to G Allows ifs
be modifieda access the
by protein
* METHYLATION
S
, * ACETYLATION
A
Phosphorylation
A
Ubiquitination of lysine
↳ Arganine
most
, Trimethylation of
lysine 27 histone 3 (H3K27) >
-
heterochrom
PCR2 Recognises & deposits
targets methyl group
[ Recognised by PCRI which binds to the chromatin
G it is a remodeller complex
They play an important role in dosage compensation
In mammals >
-
Shut off 1 X chromosome
Flies upregulate their X chromosome (XY)
· Heterochromatin
protein
I
& H3K9Me] chem mod = m
-
chromodomain
which
recognises
H3K9Me C anchors
HPI to that region
4 once bound can dimerize
bringing nucleosomes closer
together
G Recruits histone Methyltransferases
SWI / SNF Chromatin remodeler recognises
4 ↳ ATP dependent
Destabilizes/repositions
mechanism
nucleosomes >
-
access to pro
>
- RNA Pol
>
-
Basal TF
